Journal highlights novel paper by cardiovascular scientist with editorial

Posted by pt91 at Aug 24, 2015 11:26 AM |
New paper by Professor Toru Suzuki chosen as Editor’s Choice

A cardiovascular scientist from Leicester has had his latest paper highlighted with an editorial in the publishing journal.

Professor Toru Suzuki from the Department of Cardiovascular Sciences has recently published ‘Modulation of cardiac fibrosis by Krüppel-like factor 6 through transcriptional control of thrombospondin 4 in cardiomyocytes’ in Cardiovascular Research. The paper was chosen as an Editor’s Choice and to be accompanied with an editorial as it addresses the mechanisms of cardiac fibrosis, a process that has been of intense recent interest as this is the damaging sequelae of most chronic diseases affecting the heart, such as hypertension and heart failure.

Professor Suzuki said: “Fibrosis of the heart, as well as other organs such as the liver are the final consequence of chronic disease processes such as heart failure. Sadly, fibrosis is irreversible, and it is important to treat and prevent the condition, and to understand underlying mechanisms to identify new potential targets for further therapeutic exploitation.

“We have identified a new molecular pathway regulating fibrosis of the heart, and interestingly, this was regulated by the cardiac muscle cell (cardiomyocyte) rather than the cardiac fibroblast, the latter being assumed a priori to regulate fibrosis, through release of regulating factors from the cardiomyocyte allowing for a new concept of cell-cell interaction/regulation.

“Identification of this new pathway might lead to development of new treatments to prevent fibrosis and therefore of heart failure, and further generalisation to preventive treatment of fibrosis of other organs, such as the liver.”

Share this page: