Healthy volunteers needed

Posted by ac652 at Sep 01, 2016 09:39 AM |
Opportunity to take part in cancer research.

Healthy volunteers are required to help researchers investigate whether two drugs - Aspirin and Ticagrelor - could be helpful in reducing the spread of cancer from its original site to other parts of the body.

Cancer cells can enter the bloodstream and circulate around the body as circulating cancer cells. These cells can start growing at different parts of the body to form metastases.

Platelets are blood cells that help the blood to clot when there is an injury.  We know that circulating cancer cells interact with platelets in the blood. This may help protect the cancer cells and spread them throughout the body.

Aspirin and Ticagrelor block platelets and are safely used to treat patients who have had a heart attack. We understand the way these drugs work and the researchers now want to find out if blocking platelets using these drugs can affect how cancer spreads and learn about how this happens.

In this study healthy volunteers will take both Aspirin and Ticagrelor by themselves. Then they will take both of them together.

The researchers will take blood samples when treatment starts, and at two weeks, four weeks, six weeks and eight weeks when the study ends.

They will take platelets from the blood sample and use these in laboratory studies to see what impact the drugs have had on the interaction between the platelets and cancer cells grown in the lab.

Visit this page for more information about the study.

If you would like to take part or request further information please contact Clinical Research Fellow, Dr Meera Chauhan via 0116 258 3385 or email ticonc@le.ac.uk

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