Structure-function relationships in ion channels and receptors PhD supervisors

Professor Nicholas Brindle

  • Molecular mechanisms in signal transduction
  • Protein engineering
  • Cardiovascular disease
  • Drug discovery

Dr Noel Davies

  • Physiology and biophysics of K+ channels
  • Regulation of K+ channels by haem and carbon monoxide
  • Regulation of cardiac Ca2+ currents by nitric oxide
  • Developing analysis software for electrophysiological data

Professor Richard Evans

  • Structure-function studies on P2X receptors for ATP
  • Understanding the molecular basis of antagonist action at P2X receptors
  • The contribution of the intracellular region of P2X receptors to channel properties
  • Tracking P2X receptors with fluorescence reporters.

Professor Bibek Gooptu - bg129@le.ac.uk

  • Misfolding and conformational diseases
  • Structural and biophysical characterisation of disease mechanisms and novel therapeutic strategies
  • Alpha1-antitrypsin deficiency and the serpinopathies
  • Ex vivo and in vitro studies of lung and liver disease

Professor Martyn Mahaut-Smith

  • Signalling in the platelet and its precursor cell
  • Thrombosis, haemostasis and platelet production
  • Calcium signalling through ion channels and G-protein-coupled receptors
  • Specialised membrane invagination systems in cardiomyocytes, platelets and their precursors

Dr John Mitcheson

  • Ion channel physiology and pharmacology
  • Molecular and structural basis of voltage gated potassium channel gating, pharmacology and regulation by intracellular signalling pathways
  • Cellular cardiac electrophysiology and mechanisms of arrhythmia
  • The role of hERG and hEAG channels in cancer initiation and progression

Professor Christine Pullar

  • Investigation of underpinning cellular and physiological mechanisms in wound repair and scarring in skin
  • Development of treatments to prevent skin and organ fibrosis
  • Biophysical analysis of how cells sense directional signals
  • Development of treatments to heal chronic wounds

Dr Ralf Schmid

  • Molecular Modelling of P2X Receptors and Ion Channels Evolution of Functional Diversity in Protein Families
  • Functional Annotation of Protein Sequences
  • Alternative Splicing and its Effect on Protein Structure

Dr Nina Storey

  • Ion channel physiology and pharmacology
  • Regulation of voltage gated potassium channels by intracellular signalling pathways and pharmacology
  • Cellular cardiac electrophysiology and mechanisms of ischaemia reperfusion injury
  • Mitochondrial function and dysregulation in ischaemic heart disease

Professor Geerten Vuister

  • Regulation of Ca2+ transport
  • NMR methods development
  • Structure validation
  • Computational tools for Biomolecular NMR

Dr Gary Willars

  • GPCR-mediated signalling and regulation, with particular focus on receptors for neuromedin U and GLP-1
  • Possible cellular roles of proinsulin C-peptide

Share this page: