Structure, dynamics and assembly of macromolecular complexes PhD supervisors

Dr Alfredo De Biasio

• Structural Biology: Cryo-EM, X-ray crystallography and Nuclear Magnetic Resonance

• Structure and function of eukaryotic DNA polymerases

• Molecular mechanisms of DNA replication

• Molecular mechanisms of maintenance of DNA integrity


Professor Mark Carr

  • Structure-based drug discovery and design
  • Antibody-assisted structure-based drug discovery

Dr Shaun Cowley

  • Regulation of gene expression via histone deacetylase (HDAC) enzymes• Embryonic stem (ES) cell differentiation
  • Generation of CRISPR/Cas9 knock-out and knock-In mice
  • Epigenetics of cancer cells

Cyril Dominguez

  • Structural Biology
  • RNA biology
  • Protein-RNA interactions
  • Drug screening

Professor Ian Eperon

  • Mechanisms of RNA splicing
  • Splice site selection and alternative splicing, regulation and role of quadruplexes
  • Single molecule imaging of assembly of splicing complexes
  • Action at a distance on RNA chains: use of modelling and chemical biology

Professor Bibek Gooptu - bg129@le.ac.uk

  • Misfolding and conformational diseases
  • Structural and biophysical characterisation of disease mechanisms and novel therapeutic strategies
  • Alpha1-antitrypsin deficiency and the serpinopathies
  • Ex vivo and in vitro studies of lung and liver disease

Dr Olga Makarova

  • Structure determination of splicing-regulatory complexes using electron microscopy
  • Analysis of function and structure of essential splicing factors
  • Evolution of splicing machinery from low to high eukaryotes
  • Splicing as a prognostic tool in cancer

Professor Peter Moody

  • Enzyme mechanisms
  • Developing structural biology techniques
  • Neutron crystallography

Professor Daniel Panne

  • Structural Biology: cryoEM and X-ray crystallography
  • Molecular mechanisms of gene regulation
  • Regulation of higher order chromatin structure and assembly
  • Signalling in the innate immune system

Dr Andrey Revyakin

  • Molecular mechanisms of transcription initiation
  • Single-molecule imaging of assembly of macro-molecular complexes
  • Super-resolution microscopy
  • Bottom-up nano-engineering

Dr Thomas Schalch

  • Mechanisms of gene silencing.
  • Structural S. pombe biology.
  • Chromatin higher order structure and function.
  • Macromolecular machines in epigenetics and chromatin.

Dr Ralf Schmid

  • Molecular Modelling of P2X Receptors and Ion Channels Evolution of Functional Diversity in Protein Families
  • Functional Annotation of Protein Sequences
  • Alternative Splicing and its Effect on Protein Structure

Professor John Schwabe

  • Structural Biology: X-ray Crystallography, Cryo-Electron Microscopy, NMR Spectroscopy
  • Molecular mechanisms of the regulation of gene expression
  • Investigating the structure and function of large histone deacetylase containing repression complexes
  • Nuclear receptors and their role in metabolism, development and disease

Dr Sue Shackleton

  • The nuclear envelope proteome and its role in human inherited disease
  • Regulation of interaction networks linking the nucleus to the cytoskeleton
  • Mechanisms controlling nuclear positioning during muscle development

Dr Kayoko Tanaka

  • Structural and functional studies of microtubule nucleation mechanism
  • Obtaining mechanistic insights into microtubule anchoring matrix
  • Characterising the molecular mode of Ras-mediated Cdc42 activation from a mechanical viewpoint
  • Investigating signal components’ structural arrangements in GPCR-mediated Ras activation

Professor Geerten Vuister

  • Regulation of Ca2+ transport
  • NMR methods development
  • Structure validation
  • Computational tools for Biomolecular NMR

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