Molecular physiology of the cardiovascular system PhD supervisors

Professor Nicholas Brindle

  • Molecular mechanisms in signal transduction
  • Protein engineering
  • Cardiovascular disease
  • Drug discovery

Professor John Challiss

  • G protein-coupled receptor (GPCR) molecular pharmacology
  • Regulating GPCR function in the cardiovascular system
  • Regulating signal transduction in health and disease
  • Understanding the importance of glial cells in CNS regulation

Dr Noel Davies

  • Physiology and biophysics of K+ channels
  • Regulation of K+ channels by haem and carbon monoxide
  • Regulation of cardiac Ca2+ currents by nitric oxide
  • Developing analysis software for electrophysiological data

Professor Richard Evans

  • Structure-function studies on P2X receptors for ATP
  • Understanding the molecular basis of antagonist action at P2X receptors
  • The contribution of the intracellular region of P2X receptors to channel properties
  • Tracking P2X receptors with fluorescence reporters.

Professor Martyn Mahaut-Smith

  • Signalling in the platelet and its precursor cell
  • Thrombosis, haemostasis and platelet production
  • Calcium signalling through ion channels and G-protein-coupled receptors
  • Specialised membrane invagination systems in cardiomyocytes, platelets and their precursors

Dr John Mitcheson

  • Ion channel physiology and pharmacology
  • Molecular and structural basis of voltage gated potassium channel gating, pharmacology and regulation by intracellular signalling pathways
  • Cellular cardiac electrophysiology and mechanisms of arrhythmia
  • The role of hERG and hEAG channels in cancer initiation and progression

Dr Nina Storey

  • Ion channel physiology and pharmacology
  • Regulation of voltage gated potassium channels by intracellular signalling pathways and pharmacology
  • Cellular cardiac electrophysiology and mechanisms of ischaemia reperfusion injury
  • Mitochondrial function and dysregulation in ischaemic heart disease

Dr Catherine Vial

  • P2 receptors
  • Extracellular nucleotide signalling
  • Airways and asthma
  • Hematic/blood cells

Dr Gary Willars

  • GPCR-mediated signalling and regulation, with particular focus on receptors for neuromedin U and GLP-1
  • Possible cellular roles of proinsulin C-peptide

Dr Jonathan Willets

  • G protein-coupled receptor (GPCR) molecular pharmacology
  • Regulating GPCR function in the cardiovascular system
  • Regulating signal transduction in health and disease
  • The role of endocannabinoids in reproductive health

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