Mechanisms and Principles of Regulation of Gene Expression PhD Supervision

Dr Shaun Cowley

  • Regulation of gene expression via histone deacetylase (HDAC) enzymes
  • Embryonic stem (ES) cell differentiation
  • Generation of CRISPR/Cas9 knock-out and knock-In mice
  • Epigenetics of cancer cells

Cyril Dominguez

  • Structural Biology
  • RNA biology
  • Protein-RNA interactions
  • Drug screening

Professor Ian Eperon

  • Mechanisms of RNA splicing
  • Splice site selection and alternative splicing, regulation and role of quadruplexes
  • Single molecule imaging of assembly of splicing complexes
  • Action at a distance on RNA chains: use of modelling and chemical biology

Dr Ildiko Gyory

  • Transcriptional regulation of B lymphocyte development
  • Oncogenes and tumour suppressors in B lymphoid cancer
  • Cell-type specific regulation of cell cycle genes
  • Context-dependent switch from oncogenic to tumour suppressor function

Dr Olga Makarova

  • Structure determination of splicing-regulatory complexes using electron microscopy
  • Analysis of function and structure of essential splicing factors
  • Evolution of splicing machinery from low to high eukaryotes
  • Splicing as a prognostic tool in cancer

Dr Helen O'Hare

  • Molecular mechanisms of bacterial sensory perception and signal transduction
  • Role of bacterial serine threonine protein kinases in regulating bacterial physiology
  • Metabolism of Mycobacterium tuberculosis during infection
  • Regulation of gene expression in Mycobacterium tuberculosis

Dr Andrey Revyakin

  • Molecular mechanisms of transcription initiation
  • Single-molecule imaging of assembly of macro-molecular complexes
  • Super-resolution microscopy
  • Bottom-up nano-engineering

Professor John Schwabe

  • Structural Biology: X-ray Crystallography, Cryo-Electron Microscopy, NMR Spectroscopy
  • Molecular mechanisms of the regulation of gene expression
  • Investigating the structure and function of large histone deacetylase containing repression complexes
  • Nuclear receptors and their role in metabolism, development and disease

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