Cell physiology and pharmacology PhD supervisors

Professor John Challiss

  • G protein-coupled receptor (GPCR) molecular pharmacologyRegulating GPCR function in the cardiovascular system
  • Regulating signal transduction in health and disease
  • Understanding the importance of glial cells in CNS regulation

Dr Noel Davies

  • Physiology and biophysics of K+ channels• Regulation of K+ channels by haem and carbon monoxide
  • Regulation of cardiac Ca2+ currents by nitric oxide
  • Developing analysis software for electrophysiological data

Professor Bibek Gooptu - bg129@le.ac.uk

  • Misfolding and conformational diseases
  • Structural and biophysical characterisation of disease mechanisms and novel therapeutic strategies
  • Alpha1-antitrypsin deficiency and the serpinopathies
  • Ex vivo and in vitro studies of lung and liver disease

Professor Martyn Mahaut-Smith

  • Signalling in the platelet and its precursor cell
  • Thrombosis, haemostasis and platelet production
  • Calcium signalling through ion channels and G-protein-coupled receptors
  • Specialised membrane invagination systems in cardiomyocytes, platelets and their precursors

Dr John Mitcheson

  • Ion channel physiology and pharmacology
  • Molecular and structural basis of voltage gated potassium channel gating, pharmacology and regulation by intracellular signalling pathways
  • Cellular cardiac electrophysiology and mechanisms of arrhythmia
  • The role of hERG and hEAG channels in cancer initiation and progression

Professor Christine Pullar

  • Investigation of underpinning cellular and physiological mechanisms in wound repair and scarring in skin
  • Development of treatments to prevent skin and organ fibrosis
  • Biophysical analysis of how cells sense directional signals
  • Development of treatments to heal chronic wounds

Dr Nina Storey

  • Ion channel physiology and pharmacology
  • Regulation of voltage gated potassium channels by intracellular signalling pathways and pharmacology
  • Cellular cardiac electrophysiology and mechanisms of ischaemia reperfusion injury
  • Mitochondrial function and dysregulation in ischaemic heart disease

Dr Catherine Vial

  • P2 receptors
  • Extracellular nucleotide signalling
  • Airways and asthma
  • Hematic/blood cells

Dr Gary Willars

  • GPCR-mediated signalling and regulation, with particular focus on receptors for neuromedin U and GLP-1
  • Possible cellular roles of proinsulin C-peptide

Dr Jonathan Willets

  • G protein-coupled receptor (GPCR) molecular pharmacology
  • Regulating GPCR function in the cardiovascular system
  • Regulating signal transduction in health and disease
  • The role of endocannabinoids in reproductive health

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