Cancer and cell biology PhD supervisors

Professor Mark Carr

  • Structure-based drug discovery and design
  • Antibody-assisted structure-based drug discovery

Dr Mohammed El-Mezgueldi

  • Molecular mechanism of regulation of muscle contraction
  • Actin cytoskeleton
  • Genetic cardiomyopathies
  • Biophysical, kinetic and thermodynamic approaches

Professor Andrew Fry

  • Cell cycle control and cancer biology
  • Molecular mechanisms of mitosi
  • Microtubule cytoskeleton and centrosome organization
  • Protein kinase activation and inhibition

Dr Ildiko Gyory

  • Transcriptional regulation of B lymphocyte development
  • Oncogenes and tumour suppressors in B lymphoid cancer
  • Cell-type specific regulation of cell cycle genes
  • Context-dependent switch from oncogenic to tumour suppressor function

Dr Salvador Macip

  • Understanding the molecular mechanisms involved in ageing and developing strategies to slow down the process
  • Defining novel personalized therapies for B cell malignancies
  • Characterization of the p53 pathway

Dr Olga Makarova

  • Structure determination of splicing-regulatory complexes using electron microscopy
  • Analysis of function and structure of essential splicing factors
  • Evolution of splicing machinery from low to high eukaryotes
  • Splicing as a prognostic tool in cancer

Dr John Mitcheson

  • Ion channel physiology and pharmacology
  • Molecular and structural basis of voltage gated potassium channel gating, pharmacology and regulation by intracellular signalling pathways
  • Cellular cardiac electrophysiology and mechanisms of arrhythmia
  • The role of hERG and hEAG channels in cancer initiation and progression

Dr Raj Patel

  • Mammalian cell cycle
  • Mechanism of chromosome segregation
  • The Mitotic checkpoint and apoptosis

Dr Sally Prigent

  • Receptor tyrosine kinases
  • Signalling adaptor/scaffold proteins
  • Regulation of protein complex formation in signalling pathways
  • Mechanisms of cell migration

Professor Christine Pullar

  • Investigation of underpinning cellular and physiological mechanisms in wound repair and scarring in skin
  • Development of treatments to prevent skin and organ fibrosis
  • Biophysical analysis of how cells sense directional signals
  • Development of treatments to heal chronic wounds

Dr Sue Shackleton

  • The nuclear envelope proteome and its role in human inherited disease
  • Regulation of interaction networks linking the nucleus to the cytoskeleton
  • Mechanisms controlling nuclear positioning during muscle development

Dr Kayoko Tanaka

  • Structural and functional studies of microtubule nucleation mechanism
  • Obtaining mechanistic insights into microtubule anchoring matrix
  • Characterising the molecular mode of Ras-mediated Cdc42 activation from a mechanical viewpoint
  • Investigating signal components’ structural arrangements in GPCR-mediated Ras activation

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