Respiratory Sciences PhD, MD, and MPhil Supervisors

Dr Yassine Amrani

  • Use of translational bench-to-bedside research to identify novel therapeutic approaches for the treatment of chronic obstructive pulmonary disease

Professor Peter Andrew

  • Molecular and cellular studies of host and bacterial responses in infection and disease and pathogen/environmental interactions especially involving Streptococcus pneumoniae and Listeria monocytogenes

Professor Mike Barer

  • Interface between bacterial physiology and human infections, principally those involving the gastrointestinal tract and tuberculosis

Dr Caroline Beardsmore

  • Respiratory physiology based in a clinical environment
  • Mechanics of breathing, development and clinical physiology

Professor Peter Bradding

  • Pathophysiology of asthma with a particular focus on ion channels and mast cell-airway smooth muscle

Professor Chris Brightling

  • Immunopathogenesis of airway disease namely asthma, chronic obstructive pulmonary disease and chronic cough

Professor Andrea Cooper

  • Definition of the factors impacting expression of immunity in the lung, particularly tuberculosis
  • The role of early innate events in driving coordinated immune responses
  • The role of cytokines and chemokines in initiation, expression and regulation of immunity
  • The role of lymphocyte priming, differentiation and migratory capacity in prolonged expression of immunity
  • The role of the inflamed environment in regulating the expression of immunity

Professor David Cousins - dc282@le.ac.uk

  • T-cell function in respiratory disease, in particular asthma and Chronic Obstructive Pulmonary Disease
  • Development and function of human Innate Lymphoid Cells (ILCs)

Dr Erol Gaillard

  • Airway epithelial cell biology especially the role of epithelial ion channels and their impact on mucociliary clearance in conditions like asthma, cystic fibrosis and chronic obstructive pulmonary disease

Dr Natalie Garton - njg17@le.ac.uk

  • Lipid bodies of pathogenic bacteria, in particular Mycobacterium tuberculosis
  • Spectroscopic methods to monitor bacterial adaptation

Professor Bibek Gooptu - bg129@le.ac.uk

  • Ex vivo and in vitro studies of lung and liver disease
  • Use of structural biology methods to understand disease mechanisms and develop new therapies
  • Interstitial lung disease, inflammation and fibrosis
  • Alpha1-antitrypsin deficiency and the serpinopathies
  • Misfolding and conformational diseases

Dr Pranab Haldar

  • Epidemiology of latent and active tuberculosis

Dr Galina Mukamolova

  • Molecular mechanisms of bacterial dormancy and resuscitation
  • Role of mycobacterial serine-threonine kinases in growth, cell wall remodelling and dormancy
  • Antimicrobial tolerance
  • Biomarkers of non-replicating persistence

Dr Cat Pashley - chp5@le.ac.uk

  • Understanding the role fungal allergy and/or colonisation plays in causing and exacerbating respiratory diseases such as asthma, COPD or cystic fibrosis
  • Investigating the interaction between the respiratory mycobiome and bacteriome
  • Understanding the effect antifungal or antibacterial drugs may have on the mycobiome and bacteriome
  • Developing approaches to identify and quantify fungal exposure in the environment
  • Understanding the relationship between fungal exposure and respiratory health
  • Investigating the role the environmental use of fungicides may have on the development of resistance to antifungal drugs used clinically

Professor Salman Siddiqui

  • Mechanisms of airway remodelling and repair in asthma
  • Severe asthma phenotyping
  • Biomarkers of severe asthma
  • Structure function relationships in asthma with a focus on computational models
  • Applied physiology and functional imaging (MRI and CT systems)
  • Phenotyping acute exacerbations of cardio respiratory disease
  • Exhaled breath metabolomics

 

Professor Andy Wardlaw

  • Eosinophil biology, particularly as it relates to the pathogenesis of asthma
  • Drug development in asthma
  • Hypereosinophilic disease
  • Fungal diseases of the lung, in particular allergic fungal airway disease

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