About the Project
The singularity of Pneumopath lies in its multi-facted approach, its breadth of study of bacterial strains and of individual susceptibility and its computational analysis.
The project comprised six distinct but overlapping scientific workpackages with different objectives:
Workpackage 1
(lead by the Swedish Institute for Infectious Disease Control) - a study of the molecular epidemiology and genetic characterisation of antibiotic susceptible and resistant pneumococcal isolates.
Workpackage 2
(lead by the University of Leicester) - a study into the identification of new host loci confering innate resistance (or susceptibility) to invasive pneumococcal disease.
Workpackage 3
(lead by the University of Siena) - a study into the definition of parameters of pneumococcal infection in the animal host.
Workpackage 4
(lead by Radboud University) - a study into the definition of parameters of pneumococcal infection in in vitro cell culture models.
Workpackage 5
(lead by the Centre National de la Recherche Scientifique, Toulouse) - a study of the features of the central metabolism of Steptococcus pneumonaie.
Workpackage 6
(lead by the Instituto de Engenharia de Sistemas e Computadores, Lisbon) - through a semantic web infrastructure, the development of a shared data repository and dedicated data processing facilities for the subsequent analysis of project data.
The collection of experiments and analyses is ideally suited to a European collaboration.
The exchange and discussion of data from partners' investigations will be discussed at regular project meetings.