Research Themes

The LCBRU specialises in translational research into common cardiovascular diseases, including coronary artery disease, hypertension, heart failure and ventricular arrhythmias - taking laboratory findings from bench to bedside. The two main research themes of the Unit are Cardiovascular Genetics and Biomarkers; and Novel Cardiovascular Interventions:

Cardiovascular Genetics and Biomarkers

The main objectives of the Genetics and Biomarkers theme are:

  • To translate our recent and on-going discoveries on the genetic basis of coronary artery disease and related conditions towards improved understanding, prevention, prediction and treatment of these common vascular diseases.

  • To extend the genomic discovery platform to other cardiovascular diseases and clinical scenarios.

  • To use our expertise in biomarker discovery to identify and test novel plasma biomarkers for diastolic heart failure, and work with Industry to develop these for clinical use.

Novel Cardiovascular Interventions

The main objectives of the Novel Cardiovascular Interventions theme are to pull through and test some of our exciting biomedical findings and concepts for their therapeutic potential. Key areas of work include:

  • Unmet challenges in percutaneous coronary intervention.

  • Minimising reperfusion injury in acute myocardial infarction.

  • Reducing risk of ventricular arrhythmias and sudden cardiac death (SCD).

  • Reducing acute kidney injury during cardiac surgery.

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