ULTIMATE: Utilising LifeMap To Investigate Malignant Arrhythmia ThErapy

Principal Investigator: Professor André Ng
Start Date: December 2009

It is widely recognised that current methods for risk stratification of sudden cardiac death (SCD) are limited. Within the LCBRU, Professor André Ng’s research group have conducted a number of studies moving research from bench to bedside. This has led to the successful development of an award-winning novel risk marker of sudden cardiac death known as the Regional Restitution Instability Index (R2I2). R2I2 is a patient-specific index calculated using data from a surface electrocardiogram (ECG). The ULTIMATE study aims to take this development further using a non-invasive technique.

Currently R2I2 is worked out using data acquired invasively. The ULTIMATE study primarily aims to investigate whether the use of exercise and pharmacological stresses can be used to develop non-invasive methods of acquiring electrocardiographic data, which can then be used to calculate R2I2.

In conjunction with colleagues in the Department of Engineering, these techniques will also incorporate body-surface potential mapping, which will significantly increase the amount of electrical data from the heart that can be detected.

Furthermore, the research aims to use body-surface mapping to explore the development of a torso map of electrical activity so that the flow of electricity can be followed with each heartbeat. Ultimately, this will lead to a non-invasive and high-resolution form of R2I2, which could have great potential to benefit patients.

For more information about the ULTIMATE study, please contact  Dr Shoaib Siddiqui (Clinical Research Fellow).



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