An observational case control study to identify the role of Microvesicles (MV) and MV derived microRNA (miRNA) in post congenital cardiac surgery acute Kidney Injury (AKI)

Principal Investigator: Mr Attilio Lotto
Start Date: October 2014

Acute kidney injury (AKI) is a complication in over one in four cardiac surgical procedures and can increase the incidence of mortality fourfold. The incidence of AKI is increasing; its pathogenesis is poorly understood, current diagnostic tests lack specificity and sensitivity, and there is no effective treatment. Improving outcomes in patients at risk of AKI has recently been defined as an NHS priority. The primary aim of this study is to determine how plasma derived microvesicles (MV), or more specifically, MV associated microRNAs (miRNA), regulate survival and signalling in post congenital cardiac surgery AKI.

The study involves a clinical and experimental research project that will combine laboratory analyses of circulating MV and miRNA from clinical studies. The study will specifically consider how MV and miRNA alter inflammatory signalling in kidneys after congenital cardiac surgery, how these are modified by important clinical risk factors, and whether they may serve as early biomarkers of injury.

For more information about this study, please contact Mr Attilio Lotto (Consultant Congenital Cardiothorasic Surgeon).

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