DHF: Biomarkers for Diastolic Heart Failure

Principal Investigator: Professor Leong Ng
Study Start: October 2012

nurse and bloods 2Heart failure is a common problem affecting the health and wellbeing of many individuals. It can cause a variety of symptoms ranging from slight shortness of breath, to severe breathlessness, fluid retention, fatigue and reduced ability to carry out day to day activites. The condition is usually caused by a failure of the heart to pump enough blood around the body - known as systolic heart failure. In some cases, however, the pumping function of the heart is normal and the symptoms may actually be caused by a failure of the heart to relax (due to an increased "stiffness" of the heart). This is known as diastolic heart failure.

The Biomarkers for Diastolic Heart Failure (DHF) study aims to examine the blood, urine and genetic make-up of around 200 people with diastolic heart failure to investigate whether the condition can be detected by differences in these biomarkers. These markers may also indicate new pathways that may be affected in this condition. This may help us understand why the number of people with diastolic heart failure is increasing, while rates of systolic heart failure are decreasing.  The study may also contribute towards designing new therapies.

Ultimately, we hope to generate a profile of the makeup of blood and urine that will help us understand how severe each patient’s individual case of heart failure is.  This will enable us to discover details on how diastolic heart failure is caused by the various complex systems in the body.

For further information about the DHF study please email Dr Prathap Kanagala (Clinical Research Fellow).

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