Athletes and military at risk of heat stroke could benefit from ‘leaky gut’ therapy

Posted by ap507 at Jun 30, 2016 12:55 PM |
University of Leicester researcher involved in study into simple nutritional supplement which could be the solution and useful for athletes taking part in the Rio Olympics 2016

Issued by University of Leicester Press Office on 30 June 2016

The health food product zinc carnosine may have value for athletes – such as those competing in the Rio Olympics - and prevent heat stroke in military personnel, according to research involving the University of Leicester.

‘Leaky gut’ is a condition where the thin mucosal barrier of the gut, which plays a role in absorbing nutrients and preventing large molecules and germs from the gut entering the blood stream, becomes less effective.

It is a particular problem for those taking part in heavy exercise or who are active in hot conditions. It can lead to ‘heat stroke’ (especially in military personnel deployed to countries with high temperatures) and gut symptoms in athletes.

A research team from Plymouth University Peninsula Schools of Medicine and Dentistry, the University of Leicester, the University of Kent and Aberystwyth University, have published a paper in the prestigious American Journal of Clinical Nutrition which claims that zinc carnosine (a health food product), taken alone or with bovine colostrum, may have value for athletes and prevent heat stroke in military personnel.

The team recruited eight volunteers who took part in a four-arm, double-blind placebo-controlled test. The volunteers were put into groups where each group received either the placebo, zinc carnosine, colostrum or zinc carnosine and colostrum for 14 days prior to standardised exercise taken two and 14 days after starting treatment.

Among the changes that occurred in the athletes during heavy exercise was a two degree centigrade rise in body temperature, which may well have been a contributing factor in causing the increased leakiness of the gut.

The clinical trial went parallel to cell culture experiments to help understand the mechanisms behind how zinc carnosine and bovine colostrum worked.

The results showed that zinc carnosine improved the performance of the mucosal barrier of the gut, and that this improvement was enhanced when supplemented with bovine colostrum. Both are readily available from health food suppliers and the research team concluded that zinc carnosine taken alone or with bovine colostrum may have value for those affected by ‘leaky gut’.

Dr Daniel March, from the University of Leicester’s Department of Infection, Immunity and Inflammation, said: “We know that athletes who partake in heavy exercise particularly in hot and humid conditions, such as those which will face the British Olympians this summer in Brazil report increased gut symptoms. This has been suggested to be a result of ‘leaky gut’.

“Our results, showing that zinc carnosine and/or colostrum prevent gut damage during exercise, may help to optimise athlete’s nutritional strategies during competition and therefore aiding them in their ultimate goal to win medals.

“The findings of this study could also be extended to both military personnel, and clinical populations as there is accumulating evidence that ‘leaky gut’ is evident in those suffering from conditions such as inflammatory bowel disease.”

One of the lead authors of the study was Professor Raymond Playford, a gastro-intestinal expert and Professor of Medicine from Plymouth University Peninsula Schools of Medicine and Dentistry.

He said: “The distinction between food products and pharmaceutical drugs is often blurred. Our research group is interested in using naturally-derived products to enhance gut health. Our findings – that zinc carnosine and/or colostrum are helpful in preventing leaky gut associated with heavy exercise – are exciting and underpinned by a thorough clinical trial supported by cell culture experiments.”

He added: “Not only has this application for athletic performance where gut symptoms can be problematic, it also has value for people exposed to high temperatures such as military personnel deployed to the Middle East. For athletes participating in this summer’s Olympic Games in Brazil our findings could be of immense help, given that they will be exercising at their peak in hot and humid conditions.”


Notes to editors:

For more information contact Dr Daniel March or email 

For more information about this news release please contact Andrew Gould,


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