Type 2 diabetes screening needs ‘reviewing’

Posted by ap507 at Oct 13, 2015 11:10 AM |
University of Leicester researchers evaluate the effectiveness of testing methods

Issued by University of Leicester Press Office on 13 October 2015

Contact pressoffice@le.ac.uk to request images.

The process for screening for Type 2 diabetes or those at high risk of the condition needs “careful re-evaluation”, according to the first study on the effectiveness of testing methods.

Diabetes screening has been advocated, yet information on the response and diagnostic rates of different screening strategies is not available.

But researchers at the University of Leicester have now found that ‘multi-step’ programmes lead to more people responding to screening invitations and the number of those needing a final test for a definite diagnosis being reduced.

This was irrespective of the invitation method, developmental status of the countries and/or whether the location of the programme is in an urban or rural setting.

The rate of people diagnosed with Type 2 diabetes in a one-step programme was 6.6 per cent, 13.1 per cent when two steps were involved, but 27.9 per cent in screening programmes involving three or four steps.

The number needed to be invited to an oral glucose tolerance test (OGTT) to detect one case of Type 2 diabetes was 15 people for one-step programmes, 7.6 for two steps and 3.6 for strategies with three or four steps.

The research, ‘Systematic review and meta-analysis of response rates and diagnostic yield of screening for type 2 diabetes and those at high risk of diabetes’, has been published in the PLOS ONE journal.

Lead researcher Professor Kamlesh Khunti, who is Professor of Primary Care Diabetes and Vascular Medicine at the University of Leicester and Co-Director of the Leicester Diabetes Centre, said: “We have been able to provide evidence for the overall response rate and yield of diabetes screening in the background of a variety of factors such as geographical area, invitation methods and locality of the population, which influences decision making when undertaking this task.

“We can conclude that performing a multi-step approach in a population screening increases the yield and decreases the number needed to screen by OGTT and in the two- step approach it even increases the initial response rate to the invitation. In terms of absolute numbers, the highest yield of diabetes, however, is obtained in the one-step studies where an OGTT is offered as a screening test to the population.

“The process of screening for Type 2 diabetes or those at high risk of diabetes needs careful re-evaluation by local policy makers in each country especially in view of our findings.”

The study was funded by the NIHR Collaboration for Leadership in Applied Health Research and Care (CLAHRC) East Midlands. CLAHRC East Midlands is a partnership of regional health services, universities and industry which turns research into cost-saving and high-quality care through cutting-edge innovation.

Funding also came from the NIHR Biomedical Research Unit in Nutrition, Diet and Lifestyle at the University Hospitals of Leicester NHS Trust and Loughborough University.

The Leicester Diabetes Centre, a leading Centre in diabetes research and education, is led by Professor Kamlesh Khunti and Professor Melanie Davies from the University of Leicester and Leicester’s Hospitals. The Leicester Diabetes Centre is an alliance between the University Hospitals of Leicester NHS Trust (Leicester’s Hospitals), the University of Leicester, the local community and Primary Care and is located at Leicester General Hospital.

To access the article, visit http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0135702.


Notes to editors

  • For further details, to arrange an interview or more photographs, email oliver.jelley@ojpr.co.uk or call 07803 003811 or 01604 882342.
  • The National Institute for Health Research (NIHR) is funded by the Department of Health to improve the health and wealth of the nation through research. Since its establishment in April 2006, the NIHR has transformed research in the NHS. It has increased the volume of applied health research for the benefit of patients and the public, driven faster translation of basic science discoveries into tangible benefits for patients and the economy, and developed and supported the people who conduct and contribute to applied health research. The NIHR plays a key role in the Government’s strategy for economic growth, attracting investment by the life-sciences industries through its world-class infrastructure for health research. Together, the NIHR people, programmes, centres of excellence and systems represent the most integrated health research system in the world. For further information, visit http://www.nihr.ac.uk
  • NIHR CLAHRC East Midlands is a partnership of regional health services, universities and industry which turns research into cost-saving and high-quality care through cutting-edge innovation. For further information, visit http://www.clahrc-em.nihr.ac.uk/
  • For more information about the NIHR Leicester-Loughborough Diet, Lifestyle and Physical activity Biomedical Research Unit, visit http://www.ll.dlpa.bru.nihr.ac.uk.

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