Carbon Dioxide and Brain Blood Flow

Carbon Dioxide and Brain Blood Flow

Series Name Doctoral College Week
Speaker Dr Jatinder Minhas, College of Life Sciences
Type Lectures & Talks
When 25 Feb 2020, 05:00PM - 07:00PM
Venue Film Theatre, Ground Floor, Attenborough Seminar Block University of Leicester University Road Leicester LE1 7RH
Open To Public
Ticket Price Free
For Bookings Contact Kelly McCormack km423@le.ac.uk

We welcome the public audience to join us for our new series of the Doctoral Inaugural Lectures!

About this Event

These Inaugural Lectures are where the very best of our research degree graduates get the chance to return and share their work and their passion for research with the University and the public.

Lecture will run from 17:00-18:00 followed with a reception.

Free entry but booking essential!

See you there :)

Any dietary requirements please email km423@le.ac.uk.

Dr Jatinder Minhas, College of Life Sciences

Carbon Dioxide and Brain Blood Flow

A change in arterial carbon dioxide (PaCO2) exerts a potent effect on the cerebral vasculature (brain blood vessels). Consequently, PaCO2 is a key confounder in cerebral haemodynamic studies that must be measured. Through measurement of PaCO2 across its physiological range, relationships with all key systemic and cerebral haemodynamic variables have been deduced. In healthy humans, this knowledge has provided opportunities to compare and contrast sensitivities and directions of relationships between variables and PaCO2 change. This knowledge has permitted careful translation of PaCO2 manipulation (for example via hyperventilation) in acute stroke patients. Furthermore, this work has prompted consideration of the natural history of PaCO2 change post-acute stroke, unearthing previously unreported variation in the acute stroke period. Despite successful translation of a cerebral autoregulation (CA – control of brain blood flow) targeted intervention in an acute stroke population, several questions remain. Does the presence of hypocapnia (low carbon dioxide levels) in acute stroke represent pathology or a protective mechanism? Can hypocapnia be accentuated to improve CA and overall outcome? This talk will provide an update on our current understanding of PaCO2 and CA, in addition to providing a viewpoint on potential PaCO2 based interventions.

Jatinder is a National Institute for Health Research (NIHR) Clinical Lecturer in Older People and Complex Health Needs at the University of Leicester. Prior to securing this lectureship, Jatinder completed a highly successful Dunhill Medical Trust Fellowship gaining local (University Hospitals of Leicester NHS Trust), national (Royal College of Physicians) and international (European Stroke Organisation) prizes for his doctoral work. Jatinder’s doctoral project titled ‘Is it feasible to manipulate carbon dioxide levels to improve impaired cerebral autoregulation in acute haemorrhagic stroke?’ provided training in the delivery of cerebral haemodynamic studies and acute stroke trials. This firm foundation has led to Jatinder developing independent collaborations with the University of British Columbia, University of Manchester, and Northwestern Medicine, Chicago and Hospital Sao Rafael, Salvador, Brazil. In addition to his research commitments, Jatinder works as a Specialist Registrar in Geriatric, Stroke and General Medicine at the University Hospitals of Leicester NHS Trust.

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