'DNA non-homologous end-joining: the mechanism and developmental roles'

Series Name Genome Science Theme Seminar
Speaker Dr Penny Jeggo, University of Sussex
Type Lectures & Talks
When 17 Jun 2015, 02:00PM - 03:00PM
Venue Bennett link lower ground floor
Open To University staff and students
For Bookings Contact Lisa Boulton lmb24@Le.ac.uk

DNA double strand breaks (DSBs) are a significant lesion for a cell, which can lead to cell death if unrepaired or a step in the aetiology of carcinogenesis if misrepaired. DNA non-homologous end-joining (NHEJ) represents the major process for the repair of non-replication associated DSBs in mammalian cells. I will discuss the basic mechanism, its fidelity and its interplay with other DSB repair pathways.

Patients with defects in NHEJ proteins will be discussed, including a recently identified patient with mutations in XRCC4, which provides insight into the mechanism of NHEJ. The clinical features of these patients provides insight into the developmental roles of NHEJ. I will also discuss further insight into the developmental role of NHEJ which have been obtained using a mouse model for LIG4 Syndrome, a disorder caused by NHEJ deficiency.

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