Professorial Inaugural Lecture: 'Hide and Seek: Searching for Cancer in the Blood'

Series Name Professorial Inaugural Lecture
Speaker Professor Jacqui Shaw, Department of Cancer Studies and Molecular Medicine
Type Lectures & Talks
When 07 Oct 2014, 05:30PM - 06:30PM
Venue Ken Edwards Building, Lecture Theatre 1
Open To Public
Ticket Price Free
For Bookings Contact Anyone wishing to attend a lecture, whether student, staff or public, should contact inaugural@le.ac.uk.

Professor Jacqui Shaw of the Department of Cancer Studies and Molecular Medicine will give her Professorial Inaugural Lecture on 7 October in the Ken Edwards Building, Lecture Theatre 1.

Summarising her lecture, Professor Shaw said: “We are moving into the era of personalized medicine, where molecularly targeted therapy can be selected based on knowledge of the key genetic alterations that drive malignancy in each tumour. However, tissue is not always available and tissue biopsy can be costly, painful and a potential risk to the patient. The “liquid biopsy” is therefore an attractive alternative, to detect and monitor cancer by blood tests. The current FDA-approved liquid biopsy measures the number of circulating tumour cells (CTC) in a blood sample to give information about overall survival. However, many patients with cancer do not have any CTCs in their blood even when they have advanced disease. The potential predictive value of circulating free tumour derived DNA in the blood, termed circulating tumour DNA (ctDNA), as a liquid biopsy is much more exciting. This ctDNA based liquid biopsy allows us to “see” genetic changes that are happening in a cancer in real time and hopefully help us to target therapy accordingly.

"This inaugural lecture will summarize highlights of my research career over the last 20 or so years at Leicester. I will discuss the development of my interests in cancer research with particular emphasis on the liquid biopsy and what we can learn about cancer through the blood.”

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