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'Modelling the low attentive and high impulsive subtype of adult ADHD in the 5-choice continuous performance task in female rats'

Series Name Psychology Invited Speaker
Speaker Professor Jo Neill
Type Lectures & Talks
When 28 Nov 2013, 04:00PM - 05:00PM
Venue Frank and Katherine May Lecture Theatre, Henry Wellcome Building
Open To University staff and students
For Bookings Contact Giorgio Fuggetta g.fuggetta@le.ac.uk

Presented by Professor Jo Neill, Professor of Psychopharmacology, Manchester Pharmacy School, University of Manchester.

Invited by Dr Andrew Young.

The 5-choice continuous performance task (5C-CPT) is an enhanced version of the 5-choice serial reaction time task (5-CSRTT) for use in rodents. The 5C-CPT assesses vigilance in a way that is similar to the human CPT, in comparison to the 5-CSRTT that assesses sustained attention (Barnes et al. 2012). Disturbances in attention and inhibitory control play a central role in the symptomatology of ADHD.

Selection of rats within a normal “population” that display reduced sustained attention and high impulsivity may provide a translational model for the different subtypes of adult ADHD. The aim of our current work is to compare the effects of psychostimulant (methylphenidate) and non-stimulant (atomoxetine) drugs on measures of attention, impulsivity and performance in rats separated into high and low-performers in the 5C-CPT based on attentive responses and impulsivity measures.

Results suggest that high impulsive and low attentive animals respond differentially to the effects of both stimulant and nonstimulant drugs. These data provide validation of a rat model for both the low attentive and high impulsive subtypes of adult ADHD and suggest that these subtypes could respond differentially to stimulant and nonstimulant medication. Thursday 28th November 4pm, Frank & Katherine May Lecture Theatre, Henry Wellcome

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