Paradox as the driver for Translational Research

Event details


Feb 04, 2014
from 05:30 PM to 06:30 PM


Ken Edwards Building, Lecture Theatre 1

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0116 252 2320

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Professor Gavin Murphy 

Department of Cardiovascular Sciences

Lecture Summary

Cardiac surgery is the victim of its own success. Death rates are lower than at any time in the past 40 years, however increasingly older and sicker patients are being referred for surgery. These patients are much more likely to sustain organ damage or even organ failure following surgery. Organ failure is the leading cause of death following surgery, and also contributes significantly to hospital stay and diminished quality of life following discharge. Despite years of research our understanding of the mechanisms underlying this organ injury, specifically to the lungs and kidneys, is very poor. It is recognised that these organs become inflamed following surgery and it is thought that this process when severe is the cause of organ failure. In an apparent paradox however anti-inflammatory drugs do not seem to prevent organ failure. Moreover, we have shown in our own research that several stimuli that promote organ inflammation actually prevent organ failure. Resolving these paradoxes may provide insights into these diseases and ultimately present new therapies that will benefit cardiac surgery patients.


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