Examples

The following information relates to research projects following work within the University that support the 3Rs:

What we do (services and statistics) species

REFINEMENT

TUNNEL HANDLING

We have  taken on the refined methods relating to how to pick up a mouse following a study led by led by Professor Jane Hurst at the University of Liverpool.  This method is now successfully used by our technical staff and researchers at the University of Leicester and we are proud to show how this method is carried out within our facility: Mice handled by tunnel and cupping methods showed improved performance in behavioural tests compared to traditional tail handling.

Further information can be found on the NC3Rs website.

SKIN SWABBING

Quantifying the potential of skin swabbing as a refinement for DNA sampling of laboratory fish funded by the NC3Rs.  Visit their website for further information.

REPLACEMENT

Study led by researchers from the University of Leicester, this article is one of the Top 10% most cited PLOS Biology papers of 2018.  A very good example of Replacement with the use of Drosophila: Nitric oxide-mediated posttranslational modifications control neurotransmitter release by modulating complexin farnesylation and enhancing its clamping ability.  Visit the PLOS Biology website for further information.

Study led by researchers from University of Leicester and Leicester’s Hospitals provides useful information for improving our understanding of infections such as pneumonia and sepsis.  Visit the University website for further information.

Study led by researchers from University of Leicester.  Neurons of the mesodopamine system regulate voluntary motor behaviour and reward prediction, and are severely disrupted in disorders such as Schizophrenia and Parkinson's disease  Data derived from this project will improve understanding of zebrafish dopamine circuits and will be used as a framework for developing ethically superior models of dopamine diseases. - A non-mammalian model for neurofunctional studies of vertebrate dopamine signalling.  Visit the NC3Rs website for further information.

Study led by researchers from the University of Leicester.  Invertebrate models such as the fruitfly play a significant role in replacing, refining and reducing the emphasis on mice, and have provided considerable molecular insight into these diseases. An advanced model for neurodegeneration studies in the fruit fly Drosophila melanogaster.  Visit the NC3Rs website for further information.

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