Exemplar Projects

Project Title: The validation of a novel biomarkers for therapeutic interventions in colorectal cancer

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PIs: Professor Karen Brown and Dr Sam Khan

Problem: Over a quarter of patients with colorectal cancer (CRC) present with metastatic disease for which the 5 year survival is just 8%. More effective agents are required to treat patients with metastatic disease, as well as novel prevention strategies to inhibit the development and progression of CRC. Treatment with curcumin shows promise as both a preventive and a therapy for colorectal cancer. The identification of biomarkers predicting sensitivity to curcumin would allow identification of a cohort of patients who are most likely to benefit from treatment. 

Solution: To develop robust diagnostic/prognostic biomarkers for the anticancer activity of curcumin in colorectal cancer in patients. Stratification methods include using micro-satellite instability and tumour subtypes. The capability of the biomarkers to identify patient that positively respond to curcumin treatment will be validated in explanted tumour samples. 

Patient benefit: Novel diagnostic/prognostic biomarkers will enable the stratification of patients with high-risk polyps in CRC to identify those individual who will gain the most benefit from curcumin treatment. This will open up the possibility of large stratified medicine programmes to assess the potential impact of curcumin on high risk polyps, development of CRC and CRC treatment.

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For LPMI Enquiries:

Professor Jacqui Shaw

Dr Ruth Barber

Dr Carl Edwards

Dr Riddhi Shukla

e: LPMI@le.ac.uk

t: +44 (0)116 223 1594

 

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