Juan J. Canales

Professor of Psychology, University of Tasmania, Australia

Previously University Reader, University of Leicester, UK


Email: juan.canales@utas.edu.au

Tel:
Fax:

| Professor Juan J. Canales, Division Head - Psychology

| School of Medicine, Faculty of Health, University of Tasmania, Private Bag 30, Hobart, TAS  7001, AUSTRALIA

| Tel: +61 3 6226 7471 | Fax: +61 3 6226 2883

| Email – juan.canales@utas.edu.au

| Web: http://www.utas.edu.au

Biography

My group aims to understand the biological and psychological substrates of addictions and how these overlap with the brain processes that mediate learning, memory, motivation and emotion. We investigate in humans and animals the brain mechanisms that mediate addiction vulnerability and we work on the discovery of novel, more efficacious therapies, both psychosocial and pharmacological, to treat addiction-spectrum disorders.

Editorial board memberships:

Associate Editor, Frontiers in Neuropharmacology, Frontiers Media SA

Editor, Behavioural Pharmacology, Lippincott Wiliams and Wilkins

Review Editor, Frontiers in Behavioral Neuroscience, Frontiers Media SA

Qualifications

D.Phil. (Oxford)

Websites

Neuroscience at my science blog Neuroscience Networks

Professional networksLinkedInFrontiersResearchGate

Publications

(Selected outputs for 2000-present):

  • Hay B, Henderson C, Maltby J, Canales JJ (2017) Impact of peer-based needle exchange programmes on mental health status in people who inject drugs: A nationwide New Zealand study. Frontiers in Psychiatry, 7:211 http://journal.frontiersin.org/article/10.3389/fpsyt.2016.00211/full (Journal Articles)
  • Loxton D, Canales JJ (2017) Long-term cognitive, emotional and neurogenic alterations induced by alcohol and methamphetamine exposure in adolescent rats. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 74:1-8 http://dx.doi.org/10.1016/j.pnpbp.2016.11.003 (Journal Articles)
  • Pei Y, Asif-Malik A, Hoener MC, Canales JJ (2016) A partial trace amine-associated receptor 1 agonist exhibits properties consistent with a methamphetamine substitution treatment. Addiction Biology, doi: 10.1111/adb.12410.(Journal Articles)
  • Canales JJ (2016) Adult Neurogenesis in the Hippocampus: Health, Psychopathology and Brain Disease. Academic Press, Massachusetts, USA (http://store.elsevier.com/Adult-Neurogenesis-in-the-Hippocampus/isbn-9780128019771/) (Book)
  • Pei Y, Asif-Malik A, Canales JJ (2016) Trace amines and the trace amine-associated receptor 1: Pharmacology, neurochemistry and clinical implications. Frontiers in Neuroscience, 10:148 http://dx.doi.org/10.3389/fnins.2016.00148 (Journal Articles)
  • Pei Y, Mortas P, Hoener MC, Canales JJ (2015) Selective activation of the trace amine-associated receptor 1 decreases cocaine's reinforcing efficacy and prevents cocaine-induced changes in brain reward thresholds. Progress in Neuro-Psychopharmacology and Biological Psychiatry S0278-5846(15)00124-4.http://dx.doi.org/10.1016/j.pnpbp.2015.05.014 (Journal Articles)
  • Cotter R, Pei Y, Mus LV, Harmeier A, Gainetdinov RR, Hoener M, Canales JJ (2015) The trace amine-associated receptor 1 modulates methamphetamine’s neurochemical and behavioural effects. Frontiers in Neuroscience, 9:39 http://dx.doi.org/10.3389/fnins.2015.00039. (Journal Articles)
  • Hamilton J, Lee JA, Canales JJ (2015) Chronic unilateral stimulation of the nucleus accumbens at high or low frequencies attenuates relapse to cocaine seeking in an animal model. Brain Stimulation 8(1):57-63 http://dx.doi.org/10.1016/j.brs.2014.09.018. (Journal Articles)
  • Pei, Y., Lee, J.A., Leo, D., Gainetdinov, R.R., Hoener, M.C. and Canales, J.J. (2014) Activation of the trace amine-associated receptor 1 prevents relapse to cocaine seeking. Neuropsychopharmacology 39(10):2299-308 http://dx.doi.org/10.1038/npp.2014.88. (Journal Articles)
  • Ferragud, A., Velázquez-Sánchez, C. and Canales, J.J. (2014) Modulation of methamphetamine's locomotor stimulation and self-administration by JHW 007, an atypical dopamine reuptake blocker. European Journal of Pharmacology 731: 73-79. http://dx.doi.org/10.1016/j.ejphar.2014.03.015. (Journal Articles)
  • Canales, J.J. and Ferrer-Donato, A. (2014) Prenatal exposure to alcohol and 3,4-methylenedioxymethamphetamine (ecstasy) alters adult hippocampal neurogenesis and causes enduring memory deficits. Developmental Neuroscience 36(1): 10-17. http://dx.doi.org/10.1159/000356820. (Journal Articles)
  • Velázquez-Sánchez, C., Ferragud, A., Ramos-Miguel, A., García-Sevilla, J.A. and Canales, J.J. (2013) Substituting a long-acting dopamine uptake inhibitor for cocaine prevents relapse to cocaine seeking. Addiction Biology 18(4): 633-643. http://dx.doi.org/10.1111/j.1369-1600.2012.00458.x. (Journal Articles)
  • Velázquez-Sánchez, C., Murga, J., García-Verdugo, J.M. and Canales, J.J. (2013) The atypical dopamine transport inhibitor, JHW 007, prevents amphetamine-induced sensitization and synaptic reorganization within the nucleus accumbens. Progress in Neuro-Psychopharmacology and Biological Psychiatry 44: 73-80. http://dx.doi.org/10.1016/j.pnpbp.2013.01.016. (Journal Articles)
  • Canales, J. (Ed.) (2012) Emerging Targets for Drug Addiction Treatment. New York: Nova Science Publishers. vii+230pp. (Edited Books)
  • Capilla-Gonzalez, V., Gil-Perotin, S., Ferragud, A., Bonet-Ponce, L., Canales, J.J. and Garcia-Verdugo, J.M. (2012) Exposure to N-ethyl-N-nitrosourea in adult mice alters structural and functional integrity of neurogenic sites. PLoS One 7(1): e29891. http://www.ncbi.nlm.nih.gov/pubmed/22238669. (Journal Articles)
  • Revel, F.G., Moreau, J.L., Gainetdinov, R.R., Ferragud, A., Velázquez-Sánchez, C., Sotnikova, T.D., Morairty, S.R., Harmeier, A., Groebke Zbinden, K., Norcross, R.D., Bradaia, A., Kilduff, T.S., Biemans, B., Pouzet, B., Caron, M.G., Canales, J.J., Wallace, T.L., Wettstein, J.G. and Hoener, M.C. (2012) Trace amine-associated receptor 1 partial agonism reveals novel paradigm for neuropsychiatric therapeutics. Biological Psychiatry 72(11): 934-942. http://dx.doi.org/10.1016/j.biopsych.2012.05.014. (Journal Articles)
  • Lin, Z., Canales, J.J., Björgvinsson, T., Liu, Q-R., Torres, G.E. and Caine, S.B. (2011) Monoamine Transporters: Vulnerable and Vital Doorkeepers. In S. Rahman (Ed.), Progress in Molecular Biology and Translational Science Vol 98: 1-46. London: Elsevier. http://dx.doi.org/10.1016/B978-0-12-385506-0.00001-6. (Chapters in Books)
  • Velázquez-Sánchez, C., Ferragud, A., Renau-Piqueras, J. and Canales, J.J. (2011) Therapeutic-like properties of a dopamine uptake inhibitor in animal models of amphetamine addiction. The International Journal of Neuropsychopharmacology 14(5): 655-665. http://dx.doi.org/10.1017/S1461145710000969. (Journal Articles)
  • Canales, J.J. (2010) Comparative neuroscience of stimulant-induced memory dysfunction: role for neurogenesis in the adult hippocampus. Behavioural Pharmacology 21(5-6): 379-393. http://dx.doi.org/10.1097/FBP.0b013e32833e16b6. (Journal Articles)
  • Hernandez-Rabaza, V., Navarro-Mora, G., Velazquez-Sanchez, C., Ferragud, A., Marin, M.P., Garcia-Verdugo, J.M., Renau-Piqueras, J. and Canales, J.J. (2010) Neurotoxicity and persistent cognitive deficits induced by combined MDMA and alcohol exposure in adolescent rats. Addiction Biology 15(4): 413-423. http://dx.doi.org/10.1111/j.1369-1600.2010.00259.x. (Journal Articles)
  • Ferragud, A., Velázquez-Sánchez, C., Hernández-Rabaza, V., Murga, J., Merino, V., Nácher, A., Cardá, M. and Canales, J.J. (2009) A dopamine transport inhibitor with markedly low abuse liability suppresses cocaine self-administration in the rat.. Psychopharmacology 207(2): 281-289. (Journal Articles)
  • Hernández-Rabaza, V., Llorens-Martín, M., Velázquez-Sánchez, C., Ferragud, A., Arcusa, A., Gumus, H.G., Gómez-Pinedo, U., Pérez-Villalba, A., Roselló, J., Trejo, J.L., Barcia, J.A. and Canales, J.J. (2009) Inhibition of adult hippocampal neurogenesis disrupts contextual learning but spares spatial working memory, long-term conditional rule retention and spatial reversal. Neuroscience 159(1): 59-68. http://dx.doi.org/10.1016/j.neuroscience.2008.11.054. (Journal Articles)
  • Velázquez-sánchez, C., Ferragud, A., Hernández-rabaza, V., Nácher, A., Merino, V., Cardá, M., Murga, J. and Canales, J.J. (2009) The Dopamine Uptake Inhibitor 3[alpha]-[bis(4[variant prime]-fluorophenyl)metoxy]-tropane Reduces Cocaine-Induced Early-Gene Expression, Locomotor Activity, and Conditioned Reward. Neuropsychopharmacology 34(12): 2497-507. http://dx.doi.org/10.1038/npp.2009.78. (Journal Articles)
  • Hernández-Rabaza, V., Hontecillas-Prieto, L., Pérez-Villaba, A., Velázquez-Sánchez, C., Ferragud, A., Arcusa, A., Trejo, J.L., Barcia, J.A. and Canales, J.J. (2008) The hippocampal dentate gyrus is essential for generating contextual memories of fear and drug-induced reward. Neurobiology of Learning and Memory 90(3): 553-559. http://dx.doi.org/10.1016/j.nlm.2008.06.008. (Journal Articles)
  • Canales, J.J. (2007) Adult neurogenesis and the memories of drug addiction. European Archives of Psychiatry and Clinical Neuroscience 257(5): 261-270. http://dx.doi.org/10.1007/s00406-007-0730-6. (Journal Articles)
  • Rodriguez-Alarcón, G., Canales, J.J. and Salvador, A. (2007) Rewarding effects of 3,4-methylenedioxymethamphetamine (“Ecstasy”) in dominant and subordinate OF-1 mice in the place preference conditioning paradigm. Progress in Neuro-Psychopharmacology and Biological Psychiatry 31(1): 191-199. http://dx.doi.org/10.1016/j.pnpbp.2006.08.018. (Journal Articles)
  • Hernández-Rabaza, V., Domínguez-Escribà, L., Barcia, J.A., Rosel, J.F., Romero, F.J., García-Verdugo, J.M. and Canales, J.J. (2006) Binge administration of 3,4-methylenedioxymethamphetamine (“Ecstasy”) impairs the survival of neural precursors in adult rat dentate gyrus. Neuropharmacology 51: 967-973. (Journal Articles)
  • Dominguez-Escribá, L., Hernández-Rabaza, V., Soriano-Navarro, M., Barcia, J.A., Romero, F.J., García-Verdugo, J.M. and Canales, J.J. (2006) Chronic cocaine exposure impairs progenitor proliferation but spares survival and maturation of neural precursors in adult rat dentate gyrus. European Journal of Neuroscience 24(2): 586-594. http://dx.doi.org/10.1111/j.1460-9568.2006.04924.x. (Journal Articles)
  • Canales JJ. (2005) Intermittent cortical stimulation evokes sensitization to cocaine and enduring changes in matrix and striosome neuron responsiveness. Canales JJ. Synapse. 2005 Jul;57(1):56-60. Synapse 57(1): 56-60. http://www.ncbi.nlm.nih.gov/pubmed/15858832. (Journal Articles)
  • Canales, J.J. (2005) Stimulant-induced adaptations in neostriatal matrix and striosome systems: transiting from instrumental responding to habitual behavior in drug addiction. Neurobiology of Learning and Memory 83(2): 93-103. http://www.ncbi.nlm.nih.gov/pubmed/15721792. (Journal Articles)
  • Canales JJ. (2004) Catalase-independent early-gene expression in rat brain following acute ethanol exposure. Brain Research 1016(1): 96-101. http://www.ncbi.nlm.nih.gov/pubmed/15234257. (Journal Articles)
  • Canales JJ, Elayadi A., Errami M, Llansola M. and Cauli O, Felipo V. (2003) Chronic hyperammonemia alters motor and neurochemical responses to activation of group I metabotropic glutamate receptors in the nucleus accumbens in rats in vivo. Neurobiology of Disease 14(3): 380-90. http://www.ncbi.nlm.nih.gov/pubmed/14678755. (Journal Articles)
  • Capper-Loup, C., Canales, J.J., Kadaba, N. and Graybiel, A.M. (2002) Concurrent activation of dopamine D1 and D2 receptors required to evoke neural and behavioral phenotypes of cocaine sensitization. The Journal of Neuroscience 22(13): 6218-6227. http://www.ncbi.nlm.nih.gov/pubmed/12122080. (Journal Articles)
  • Canales JJ, Capper-Loup C., Hu D, Choe ES. and Upadhyay U, Graybiel AM. (2002) Shifts in striatal responsivity evoked by chronic stimulation of dopamine and glutamate systems. Brain 125(Pt 10): 2353-63. http://www.ncbi.nlm.nih.gov/pubmed/12244091. (Journal Articles)
  • Graybiel AM, Canales JJ. (2001) The neurobiology of repetitive behaviors: clues to the neurobiology of Tourette syndrome. Advances in Neurology 85: 123-31. http://www.ncbi.nlm.nih.gov/pubmed/11530422. (Journal Articles)
  • Canales, J.J. and Graybiel, A.M. (2000) A measure of striatal function predicts motor stereotypy. Nature Neuroscience 3(4): 377-383. http://www.ncbi.nlm.nih.gov/pubmed/10725928. (Journal Articles)
  • Canales JJ, Iversen SD. (2000) Dynamic dopamine receptor interactions in the core and shell of nucleus accumbens differentially coordinate the expression of unconditioned motor behaviors. Synapse 36(4): 297-306. http://www.ncbi.nlm.nih.gov/pubmed/10819907. (Journal Articles)
  • Graybiel AM, Canales JJ. and Capper-Loup C. (2000) Levodopa-induced dyskinesias and dopamine-dependent stereotypies: a new hypothesis. Trends in the Neurosciences 23(10 Suppl): S71-7. http://www.ncbi.nlm.nih.gov/pubmed/11052223. (Journal Articles)

Research

Research projects as P.I. (since 2005):

Investigation of the trace amine-associated receptor 1 as a target for pharmacotherapy in addictive disorders, F. Hoffmann-La Roche, 2015-2016

New benztropanes with therapeutic potential in addiction to psychomotor stimulants, Spanish Ministry of Health, FIS, 2010-2014

Deep brain stimulation of the nucleus accumbens for the treatment of drug addiction, Canterbury Medical Research Foundation, 2013-2014

Trace amine receptors: new target for treatments in drug abuse, Lottery Health Board, Ministry of Internal Affairs, New Zealand, 2012-2013

Preclinical assays with new pharmacological tools for cocaine addiction, Spanish Ministry of Health, Plan Nacional Sobre Drogas, 2008-2011

Network of Addictive Disorders, Networks of Collaborative Research, ISCIII, Spanish Ministry of Health, 2007-2011

Consequences of juvenile drug polydrug abuse in an animal model: effects on adult hippocampal neurogenesis, association with memory deficits and prevention by antioxidant treatment, Fundación Biomédica MM, 2007-2010

Benztropine analogs as therapeutic agents in cocaine addiction: Neurochemical and pharmacokinetic-dynamic studies in animal models of relapse, Spanish Ministry of Education and Science, Plan Nacional, 2006-2009

Neurobiology of cocaine addiction: neuroanatomical substrates and effects on adult neurogenesis, Consellería de Cultura, Educación y Deporte, Generalitat Valenciana, 2005-2006

Share this page: