Recent Papers

Recent papers by Professor Irene Gotlobb, Department of Neuroscience, Psychology & Behaviour, University of Leicester.

Pilat AV, Proudlock FA, Mohammad S, Gottlob I. Normal macular structure measured with optical coherence tomography across ethnicity. Br J Ophthalmol. 2014 Feb 11. doi: 10.1136/bjophthalmol-2013-303119.

Kanonidou E, Gottlob I, Proudlock FA. The effect of font size on reading performance in strabismic amblyopia: an eye movement investigation. Invest Ophthalmol Vis Sci. 2014 Jan 23;55(1):451-9.

Pilat AV, Proudlock FA, Kumar P, Lee H, Papageorgiou E, Gottlob I. Macular morphology in patients with optic nerve head drusen and optic disc edema. Ophthalmology. 2014 Feb;121(2):552-7.

Barot N, McLean RJ, Gottlob I, Proudlock FA. The Effect of Colored Overlays on Reading Performance in Infantile Nystagmus. Ophthalmology. 2013 Dec 3.

Lee H, Sheth V, Bibi M, Maconachie G, Patel A, McLean RJ, Michaelides M, Thomas MG, Proudlock FA, Gottlob I.  Potential of handheld optical coherence tomography to determine cause of infantile nystagmus in children by using foveal morphology. Ophthalmology. 2013 Dec;120(12):2714-24

Lee H, Proudlock F, Gottlob I.  Is handheld optical coherence tomography reliable in infants and young children with and without nystagmus?  Invest. Ophthalmol. Vis. Sci. 2013 Dec 17;54(13):8152-9.

Sheth V, Gottlob I, Mohammad S, McLean RJ, Maconachie GD, Kumar A, Degg C, Proudlock FA. Diagnostic Potential of Iris Cross-sectional Imaging in Albinism Using Optical Coherence Tomography.  Ophthalmology. 2013 Oct;120(10):2082-90

Thomas S, Thomas MG, Andrews C, Chan WM, Proudlock FA, McLean RJ, Pradeep A, Engle EC, Gottlob I.  Autosomal-dominant nystagmus, foveal hypoplasia and presenile cataract associated with a novel PAX6 mutation.  Eur J Hum Genet.  2013 Aug 14.

Maconachie GD, Gottlob I, McLean RJ. Risk factors and genetics in common comitant strabismus: A systematic review of the literature. JAMA Ophthalmol 2013 Jul.

Barot N, McLean RJ, Gottlob I, Proudlock FA. Reading Performance in Infantile Nystagmus. Ophthalmology 2013 Jun;120(6):1232-8.

Thomas MG, Kumar A, Thompson JR, Proudlock FA, Straatman K, Gottlob I. Is high-resolution spectral domain optical coherence tomography reliable in nystagmus?  Br J Ophthalmol. 2013 Apr;97(4):534-6.

Watkins RJ, Patil R, Goult BT, Thomas MG, Gottlob I, Shackleton S. A novel interaction between FRMD7 and CASK:  evidence for a causal role in idiopathic infantile nystagmus.  Hum. Mol. Genet. 2013 May 15:22(10):2105-18.

Sheth V, Gottlob I, Mohammad S, McLean RJ, Maconachie GD, Kumar A, Degg C,Proudlock FA. Diagnostic Potential of Iris Cross-sectional Imaging in Albinism Using Optical Coherence Tomography. Ophthalmology. 2013 May 29.

Gottlob I.  Is impaired emmetropization related to foveal hypoplasia or is it specific to albinism? Invest Ophthalmol Vis Sci 2013 Apr26;54(4):2940.

Knapp CM, Proudlock FA, Gottlob I. OKN asymmetry in human subjects:  a literature review. Strabismus 2013 Mar:21(1):37-49.

Thomas MG, Gottlob I. Optical coherence tomography studies provides new insights into diagnosis and prognosis of infantile nystagmus: a review.  Strabismus. 2012 Dec;20(4):175-80

Hoffmann MB, Kaule FR, Levin N, Masuda Y, Kumar A, Gottlob I, Horiguchi H, Dougherty RF, Stadler J, Wolynski B, Speck O, Kanowski M, Liao YJ, Wandell BA, Dumoulin SO. Plasticity and stability of the visual system in human achiasma. Neuron. 2012 Aug 9;75(3):393-401.

Thomas MG, McLean RJ, Kohl S, Sheth V, Gottlob I. Early signs of longitudinal progressive cone photoreceptor degeneration in achromatopsia. Br J Ophthalmol. 2012 Jul.

McLean RJ, Windridge KC, Gottlob I. Living with nystagmus: a qualitative study. Br J Ophthalmol. 2012 Jul;96(7):981-6.

McLean RJ, Gottlob I, Proudlock FA. What we know about the generation of nystagmus and other ocular oscillations: are we closer to identifying therapeutic targets?  Curr Neurol Neurosci Rep. 2012 Jun;12(3):325-33.

Roberts EO, Proudlock FA, Martin K, Reveley MA, Al-Uzri M, Gottlob I. Reading in Schizophrenic Subjects and Their Nonsymptomatic First-Degree Relatives. Schizophr Bull. 2012 Jan 20. [Epub ahead of print].

Pieh C, Proudlock F, Gottlob I. Smooth pursuit in infants: maturation and the influence of stimulation.  Br J Ophthalmol. 2012 Jan;96(1):73-7. Epub 2011 Apr 11.

Tarpey P, Thomas S, Sarvananthan N, Mallya U, Lisgo S, Talbot CJ, Roberts EO, Awan M, Surendran M, McLean RJ, Reinecke RD, Langmann A, Lindner S, Koch M, Jain S, Woodruff G, Gale RP, Bastawrous A, Degg C, Droutsas K, Asproudis I, Zubcov AA, Pieh C, Veal CD, Machado RD, Backhouse OC, Baumber L, Constantinescu CS, Brodsky MC, Hunter DG, Hertle RW, Read RJ, Edkins S, O'Meara S, Parker A, Stevens C, Teague J, Wooster R, Futreal PA, Trembath RC, Stratton MR, Raymond FL, Gottlob I. Mutations in FRMD7, a newly identified member of the FERM family, cause X-linked idiopathic congenital nystagmus. Nat Genet. 2006 Nov;38(11):1242-4. Epub 2006 Oct 1. Erratum in: Nat Genet. 2011 Jul;43(7):720. Bastawrous, Andrew [added].

Mohammad S, Gottlob I, Kumar A, Thomas M, Degg C, Sheth V, Proudlock FA. The Functional Significance of Foveal Abnormalities in Albinism Measured Using Spectral-Domain Optical Coherence Tomography. Ophthalmology. 2011 May 11 Epub 

Thomas MG, Kumar A, Mohammad S, Proudlock FA, Engle EC, Andrews C, Chan WM, Thomas S, Gottlob I. Structural Grading of Foveal Hypoplasia Using Spectral-Domain Optical Coherence Tomography A Predictor of Visual Acuity? Ophthalmology. 2011 Apr 28 Epub

Pieh C, Proudlock F, Gottlob I. Smooth pursuit in infants: maturation and the influence of stimulation. Br J Ophthalmol. 2011 Apr 11 Epub 

Thomas MG, Crosier M, Lindsay S, Kumar A, Thomas S, Araki M, Talbot CJ, McLean RJ, Surendran M, Taylor K, Leroy BP, Moore AT, Hunter DG, Hertle RW, Tarpey P, Langmann A, Lindner S, Brandner M, Gottlob I. The clinical and molecular genetic features of idiopathic infantile periodic alternating nystagmus. Brain. 2011 Mar 134 Pt3 892-902

Kumar A, Gottlob I, McLean RJ, Thomas S, Thomas M, Proudlock FA. Clinical and Oculomotor Characteristics of Albinism Compared to FRMD7 Associated Infantile Nystagmus. Invest Ophthalmol Vis Sci. 2011 Apr 8 52 5 2306-13

Thomas MG, Kumar A, Kohl S, Proudlock FA, Gottlob I. High-Resolution In Vivo Imaging in Achromatopsia. Ophthalmology. 2011 May 118 5 882-7

Awan M, Proudlock F, Grosvenor D, Choudhuri I, Sarvananthan N, Gottlob I. An Audit of the Outcome of Amblyopia Treatment: A retrospective analysis of 322 children. Br J Ophthalmol. 2010 Aug 94 8 1007-11

Thomas MG, Thomas S, Kumar A, Proudlock FA, Gottlob I. FRMD7-Related Infantile Nystagmus. GeneReviews [Internet]. 2010

Rebecca Jane McLean, MSc, and Irene Gottlob, MD University of Leicester, Leicester, UK A Review of Nystagmus and Current Pharmacological Treatments, CML - Ophthalmology 2010;20(4):125-36.

Kanonidou E, Proudlock FA, Gottlob I. Reading strategies in mild to moderate strabismic amblyopia: an eye movement investigation. Invest Ophthalmol Vis Sci. 2010 Jul 51 7 3502-8

Betts-Henderson J, Bartesaghi S, Crosier M, Lindsay S, Chen HL, Salomoni P, Gottlob I, Nicotera P.  The nystagmus-associated FRMD7 gene regulates neuronal outgrowth and development.  Hum. Mol. Genet. 2010 Jan 15;19(2):342-51

Tischfield MA, Baris HN, Wu C, Rudolph G, Van Maldergem L, He W, Chan WM, Andrews C, Demer JL, Robertson RL, Mackey DA, Ruddle JB, Bird TD, Gottlob I, Pieh C, Traboulsi EI, Pomeroy SL, Hunter DG, Soul JS, Newlin A, Sabol LJ, Doherty EJ, de Uzcátegui CE, de Uzcátegui N, Collins ML, Sener EC, Wabbels B, Hellebrand H, Meitinger T, de Berardinis T, Magli A, Schiavi C, Pastore-Trossello M, Koc F, Wong AM, Levin AV, Geraghty MT, Descartes M, Flaherty M, Jamieson RV, Møller HU, Meuthen I, Callen DF, Kerwin J, Lindsay S, Meindl A, Gupta ML Jr, Pellman D, Engle EC.  Human TUBB3 mutations perturb microtubule dynamics, kinesin interactions, and axon guidance.  Cell. 2010 Jan 8;140(1):74-87.

Knapp CM, Gottlob I, McLean RJ, Rafelt S, Proudlock FA.  Effect of distance upon horizontal and vertical look and stare OKN.  J Vis. 2009 Nov 30;9(12):23.1-9

Kumar A, Thomas S, McLean R, Proudlock FA, Roberts E, Boggild M, Gottlob I.Treatment of acquired periodic alternating nystagmus with memantine: a case report. Clin Neuropharmacol. 2009 32(2):109-10

McLean RJ, Gottlob I.  The pharmacological treatment of nystagmus: a review.  Expert Opin Pharmacother. 2009 Aug;10(11):1805-16

Knapp CM, Gottlob I, McLean RJ, Rajabally YA, Abbott RJ, Rafelt S, Proudlock FA.
Vertical optokinetic nystagmus in Parkinson's disease.  Mov Disord. 2009 Jul 30; 24(10):1533-8.

Kumar A, Sarvananthan N, Proudlock F, Thomas M, Roberts E, Gottlob I. Asperger syndrome associated with idiopathic infantile nystagmus-a report of 2 cases. Strabismus. 2009 Apr-Jun;17(2):63-5

Sarvananthan N, Surendran M, Roberts E, Jain S, Thomas S, Shah N, Proudlock FA, Thompson JR, McLean RJ, Degg C, Woodruff G, Gottlob I. The prevalence of nystagmus: The Leicestershire nystagmus survey. Invest. Ophthalmol. Vis. Sci. 2009 May 20.

Zubcov-Iwantscheff AA, Thomke F, Goebel HH, Bacharach-Buhles M, Cordey A, Constantinescu CS, Gottlob I.  Eye movement involvement in Parry-Romberg Syndrome: a clinicopathologic case report. Strabismus. 2008 Jul-Sep;16(3):119-21.

Thomas S, Proudlock FA, Sarvananthan N, Roberts EO, Awan M, McLean R, Surendran M, Kumar AS, Farooq SJ, Degg C, Gale RP, Reinecke RD, Woodruff G, Langmann A, Lindner S, Jain S, Tarpey P, Raymond FL, Gottlob I. Phenotypical characteristics of idiopathic infantile nystagmus with and without mutations in FRMD7. Brain. 2008 May;131(Pt 5):1259-67.  2008 Mar 27.

Jain S, Farooq SJ, Gottlob I. Resolution of superior oblique myokymia with memantine. J AAPOS. 2008 Feb 12 1 87-8

Pieh C, Simonsz-Toth B, Gottlob I.  Nystagmus characteristics in congenital stationary night blindness (CSNB).  Br J Ophthalmol. 2008 Feb;92(2):236-40.

Knapp CM, Gottlob I, McLean RJ, Proudlock FA.  Horizontal and vertical look and stare optokinetic nystagmus symmetry in healthy adult volunteers.  Invest Ophthalmol Vis Sci. 2008 Feb;49(2):581-8.

Farooq SJ, Gottlob I, Benskin S, Proudlock FA. The effect of aging on torsional optokinetic nystagmus.  Invest Ophthalmol Vis Sci. 2008 Feb;49(2):589-93.

Pradeep A, Thomas S, Roberts EO, Proudlock FA, Gottlob I.  Reduction of congenital nystagmus in a patient after smoking cannabis.  Strabismus. 2008 Jan-Mar;16(1):29-32.

Farooq SJ, Gottlob I, Proudlock FA. The Effect of Aging on Torsional Optokinetic Nystagmus. Invest Ophthalmol Vis Sci. In press 2007.

Lett KS, Shah A, Gottlob I. External ophthalmoplegia as the presenting feature of amyloidosis. Strabismus 15:153-6, 2007.

Proudlock FA, Gottlob I.  Physiology and pathology of eye-head coordination.  Prog Retin Eye Res. 2007 Apr 14.

Gottlob I.  Albinism: a model of adaptation of the brain in congenital visual disorders.
Br J Ophthalmol. 2007 Apr;91(4):411-2. No abstract available.

McLean R, Proudlock F, Thomas S, Degg C, Gottlob I.  Congenital nystagmus: randomized, controlled, double-masked trial of memantine/gabapentin.  Ann Neurol. 2007 Feb;61(2):130-8.

Tarpey P, Thomas S, Sarvananthan N, Mallya U, Lisgo S, Talbot CJ, Roberts EO, Awan M, Surendran M, McLean RJ, Reinecke RD, Langmann A, Lindner S, Koch M, Jain S, Woodruff G, Gale RP, Degg C, Droutsas K, Asproudis I, Zubcov AA, Pieh C, Veal CD, Machado RD, Mutations in FRMD7, a newly identified member of the FERM family, cause X-linked idiopathic congenital nystagmus. Nat Genet. 2006 Nov 38 11 1242-4

Sabri K, Knapp CM, Thompson JR, Gottlob I. The VF-14 and psychological impact of amblyopia and strabismus. Invest Ophthalmol Vis Sci. 2006 Oct 47 10 4386-92

Sarvananthan N, Proudlock FA, Choudhuri I, Dua H, Gottlob I. Pharmacologic treatment of congenital nystagmus. Arch Ophthalmol. 2006;124:916-8.

Choudhuri I, Sarvananthan N, Gottlob I. Survey of management of acquired nystagmus in the United Kingdom. Eye. 2006 26.

Shery T, Proudlock FA, Sarvananthan N, McLean RJ, Gottlob I. The effects of gabapentin and memantine in acquired and congenital nystagmus: a retrospective study. Br J Ophthalmol. 2006;90:839-43.

Dixon-Woods M, Awan M, Gottlob I. Why is compliance with occlusion therapy for Amblyopia so hard? A qualitative study.  Arch Dis Child. 2006;91:491-4.

Rahman W, Proudlock F, Gottlob I. Oral gabapentin treatment for symptomatic Heimann-Bielschowsky phenomenon. Am J Ophthalmol. 2006;141:221-2.

Proudlock F A, Khanna A, Gottlob I. Filling-in along horizontal and vertical meridians. Invest Ophthalmol Vis Sci. 2006; 47:453-60.

Sachdev A, Proudlock FA, Abbott R, Gottlob I. Kjellin syndrome: first case with retinal changes in carriers. Neurology. 2005 Oct 11 65 7 1110

Thomas S, Farooq SJ, Proudlock FA, Gottlob I. Vertical deviation exacerbated by convergence and accommodation. Br J Ophthalmol. 2005 Oct 89 10 1371-2

Pilling RF, Thompson JR, Gottlob I. Social and visual function in nystagmus. Br J Ophthalmol. 2005 Oct 89 10 1278-81

Awan M, Proudlock FA, Gottlob I. A randomized controlled trial of unilateral strabismic and mixed amblyopia using occlusion dose monitors to record compliance. Invest Ophthalmol Vis Sci. 2005 Apr 46 4 1435-9

Valmaggia C, Proudlock F, Gottlob I. Look and stare optokinetic nystagmus in healthy subjects and in patients with no measurable binocularity. A prospective study. Klin Monatsbl Augenheilkd. 2005 Mar 222 3 196-201

Valmaggia C, Proudlock F, Gottlob I. Asymmetry of the optokinetic nystagmus in lesion of the central nervous system. Klin Monatsbl Augenheilkd. 2005 Mar 222 3 191-5

Thomas S, Critchley P, Lawden M, Farooq S, Thomas A, Proudlock FA, Constantinescu CS, Gottlob I. Stiff person syndrome with eye movement abnormality, myasthenia gravis, and thymoma. J Neurol Neurosurg Psychiatry. 2005 Jan 76 1 141-2

Thomas S, Critchley P, Lawden M, Farooq S, Thomas A, Proudlock FA, Constantinescu CS, Gottlob I. “Stiff-person syndrome with eye movements abnormality, myasthenia gravis and thymoma”. J Neurol Neurosurg Psychiatr.2005; 76:142-142.

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