Dr Volko Straub

Tel: +44  (0)116 252 3090       Email:  vs64@le.ac.uk

Research

Interests and techniques

The research of myself and my department includes the following: Long-term memory formation involves theVolko Straub Research Page Image 2 remodeling of existing synapses and the creation of novel synapses. These processes require neurons to undergo morphological changes, i.e. sprouting of new growth cones; extension and/or retraction of spines and processes; formation or removal of synapses. Previous work has demonstrated that nitric oxide plays a significant role in learning and memory formation in Lymnaea1–9, similar to its role in other vertebrate and invertebrate species. In order to study whether endogenous nitric oxide can affect neuronal growth and synapse formation in adult neurons, we studied the effect of nitric oxide signaling on neuronal regeneration and synaptic re-modeling following axonal injury of identified Lymnaea B1 and B2 neurons. This enabled us to demonstrate that nitric oxide significantly modulates both neuronal growth and synaptic re-modelling2.

Based on the observations in Lymnaea we are currently investigating the effects of nitric oxide signaling on neuronal growth and synapse formation in cortical neurons.

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Contact

Department of Neuroscience, Psychology and Behaviour
University of Leicester
University Road
Leicester
LE1 7RH

T: +44 (0)116 252 2922
E: npbenquiries@le.ac.uk

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