Dr Claire Gibson

Reader - Department of Neuroscience, Psychology & Behaviour

Deputy Head of the College of Medicine, Biological Sciences & Psychology

Contact details

Email: cg95@le.ac.uk 
Tel:+44(0)116 229 7187 / +44(0)116 252 2922

Personal details

  • PhD Neuroscience (University of Newcastle)
  • BSc Neuroscience (University of Sheffield).

Teaching

  • PS2014/8 Biological Psychology
  • PS2020 Cognitive Neuroscience Library Module
  • PS3010 Behavioural Neuroscience
  • PS3033 Psychology Across the Lifespan

Publications

Full list available

Trotman-Lucas M, Kelly ME, Janus J, Fern R, Gibson CL (2017) An alternative surgical approach reduces variability following filament induction of experimental stroke in mice.  Disease Models and Mechanisms 10: 931-938.

Percie du Sert N, Alfieri A, Allan SM, Carswell HVO, Deuchar GA, Farr TD, Gallagher L, Gibson CL, Haley MJ, Macleod MR, McColl BW, McCabe C, Morancho A, Moon LDF, O’Neill MJ, Pérez de Puig I, Planas A, Ragan CI, Rosell A, Roy LA, Ryder KO, Simats A, Sena ES, Sutherland BA, Tricklebank MD, Trueman RC, Whitfield L, Wong R, Macrae IM (2017) Refining rodent models of ischaemic stroke: pre- and post-surgery care guidelines.  Journal of Cerebral Blood Flow and Metabolism – In Press (DOI: 10.1177/0271678X17709185).

Attwood L, Gibson CL (2016) The impact of gender on cerebral stroke pathology and treatment. Neuroscience and Biobehavioural Reviews, 67: 119-124.

Subiros N, Saad H, Berlanga J, Aldana L, Garcia G, Gibson CL, Garcia D (2016) Assessment of the dose effect and therapeutic time window in preclinical studies of rhEGF and GHRP-6 co-administration for stroke therapy. Neurological Research, 19: 1-9.

Gibson CL, Bath PMW (2015) Feasibility of progesterone treatment for ischaemic stroke. Journal of Cerebral Blood Flow & Metabolism, 25: 431-439.

Trotman M, Vermehren P, Gibson CL, Fern R (2015) The dichotomy of memantine treatment for ischemic stroke; dose-dependent protective and detrimental effects. Journal of Cerebral Blood Flow & Metabolism, 35: 230-239.

Wong R, Gibson CL, Kendall D, Bath PWM (2014) Evaluating the translational potential of progesterone treatment following transient cerebral ischaemia in male mice.  BMC Neuroscience, 15:131.

Gibson CL, Srivastava K, Sprigg N, Bath PMW, Bayraktutan U (2014) Inhibition of Rho-kinase protects cerebral barrier from ischemia-evoked injury through modulations of endothelial cell oxidative stress and tight junctions. Journal of Neurochemistry, 129: 816-826.

Research

 

MRI images taken from post-stroke mice showing edematous tissue (T2-weighted scan), blood vessel anatomy (angiography scan) and lesion area in yellow (DTI scan).

Cerebral ischaemic stroke – mechanisms of injury and potential treatment strategies

Cerebral ischaemic stroke, in the UK, is the third leading cause of mortality, the leading cause of morbidity and estimated to cost the NHS £2.8 billion per year in direct costs. There is a real need for basic research to identify potential neuroprotective strategies in order to determine whether clinical investigation is warranted. My lab has a long standing research interest in the role of steroid hormones as potential protective factors following ischemic stroke. Gender also influences pathology and outcome following stroke – we are also beginning to explore the gender-specific mechanisms of injury that may be relevant following ischaemic stroke.

Key mechanisms of injury following ischaemic stroke involve apoptosis and inflammation. We are investigating, in collaboration with stroke clinicians at the University of Nottingham, molecular mechanisms that may underlie the breakdown of the blood brain barrier and treatment strategies to promote its repair. In addition, in collaboration with colleagues at Leicester (Department of Cell Physiology & Pharmacology, Department of Cardiovascular Sciences) we are pursuing an interest in the role of prostaglandins and opioid receptors following ischaemic stroke.

Experimental stroke models

In order to pursue these research questions we utilise a range of in vitro, ex vivo and in vivo experimental stroke models complimented with a number of behavioral, imaging (immunocytochemistry, MRI) and molecular biology techniques. We are also interested in the refinement of existing experimental stroke models and increasing the translational relevance of experimental data to the clinical setting. We have a current project investigating the use of structural MRI to assist in understanding the variability seen in outcome following induction of experimental stroke.

Recent grants/awards

2017-2018: National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) Skills and Knowledge Transfer Grant

2016-2018: Henry Smith Medical Charity Project Grant

2015-18: National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) - PhD Studentship.

2015-18: British Journal of Anaesthesia - PhD Studentship (with Professor Dave Lambert, Department of Cardiovascular Sciences).

Funding is also gratefully acknowleged from the following: Wellcome Trust, Rosetrees Foundation, British Society for Neuroendocrinology, MediSearch & University of Nottingham SandPit funds, Nuffield Foundation and Research Into Ageing.

Current lab members

  • Dr Melissa Trotman-Lucas 
  • Michaela Bayliss (NC3Rs Phd Student)
  • Beth Fraser (PhD student, joint with Cardiovascular Sciences)
  • Raeed Altaee (PhD Student)
  • Andrew Crofts (MRC PhD student).

Previous lab members

  • Asha Akram (PhD Student)
  • Raymond Wong (visiting PhD student, University of Nottingham)
  • Ben Coomber (Research Into Ageing funded postdoctoral student)
  • Elvina Chrysanthou, Entisar Elsaeedi (PhD student),
  • Stephen Knight (Intercalated medical student), Tim Fleming (Intercalated medical student), Nathan Price (Intercalated medical student), Luke Attwood (Intercalated medical student).

Supervision

Enquiries are welcome from potential PhD students. Apply for a PhD or MPhil in Neuroscience, Psychology and Behaviour.

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