Dr. Andrew Young

 

Associate Professor of Behavioural Neuroscience

Department of Neuroscience, Psychology and Behaviour,

and

School of Psychology

University of Leicester,
Lancaster Road,
Leicester
LE1 9HN

 

Office : MSB 305

E-mail : amjy1@leicester.ac.uk

Tel      : +44 (0)116 2297111

 

amjy

Teaching

I teach mainly in the School of Psychology, focussing on aspects of Biological Psychology to first, second and third year students.  I also teach third year options modules in the School of Biology and School of Medicine.

I teach aspects of Biological Psychology and Behavioural Neuroscience, particularly focussing on brain mechanisms controlling normal behaviour, and how these become dysfunctional in psychological and neurological diseases.

Publications

Selected recent publications

Carreño Gutiérrez, H., Colanesi, S., Cooper, B., Reichmann, F., Young, A. M. J., Kelsh, R. N., & Norton, W. H. J. (2019). Endothelin neurotransmitter signalling controls zebrafish social behaviour. Scientific Reports, 9(1), 3040. doi:10.1038/s41598-019-39907-7

Ali A.M. & Young A.M.J.  (2019) Disruption of latent inhibition by subchronic phencyclidine pretreatment in rats. Behav Brain Res, 368, Article 111901
Rickard, R., Young, A.M.J. & Gerdjikov, T.E. (2018) Cortical local field potential power is associated with behavioural detection of near-threshold stimuli in the rat whisker system: dissociation between orbitofrontal and somatosensory cortices.  Journal of Cognitive Neuroscience, 30(1):42-49
Stubbendorff, C., Molano, M., Young, A.M.J. & Gerdjikov T.V. (2018).  Encoding of behavioural choice in the prefrontal-striatal circuit: Clues from multisite single unite recordings in a go no-go task in rats. Eur.J.Neuroscience  (In Press: accepted Mar 2018))
Gupta I & Young AMJ (2018) Modulation of dopamine release by glutamate in the nucleus accumbens shell is unaffected by phencyclidine pretreatment: in vitro assessment using fast cyclic voltammetry. Brain Research, 1687, 155-161.
Asif-Malik A, Dautan, D, Young AMJ & Gerdjikov TV. (2017) Changes in cortico-accumbal network activity after phencyclidine pre-treatment: Clues to neurophysiological dysfunction in a rat model of schizophrenia. Brain Structure and Function,  doi:10.1007/s00429-017-1393-3

 

McLean, S.L., Harte, M.K., Neill, J.C. & Young A.M.J. (2017) Dopamine dysregulation in the prefrontal cortex mediates cognitive deficits in the sub-chronic PCP-model for schizophrenia: a preliminary investigation.  J Psychopharm 31(6):660-666. doi: 10.1177/0269881117704988

Yavas, E. & Young, A.M.J.. (2017) N-methyl-D-aspartate modulation of nucleus accumbens dopamine release by metabotropic glutamate receptors: fast cyclic voltammetry studies in rat brain slices in vitro.  ACS Chemical Neuroscience 8(2), 320–328; DOI: 10.1021/acschemneuro.6b00397

Jones, L., McCutcheon, J., Young, A.M.J., & Norton, W. (2015). Neurochemical measurements in the zebrafish brain. Frontiers in Behavioral Neuroscience, 9. doi: 10.3389/fnbeh.2015.00246

Young A.M.J., Stubbendorff C., Ustárroz M.V. & Gerdjikov T.V. (2015) Prefrontal neurophysiological deficits in the phencyclidine model of schizophrenia. Neuroscience 287, 157-163

Fuggetta G., Bennett, M., Duke P.A. & Young A.M.J. (2014) Quantitative electroencephalography as a biomarker for proneness toward developing psychosis. Schizophrenia Research, 153, 68-77

Chauhan, N.K., Young, A.M.J., Gibson, C.L. & Davidson, C. (2013) Inhibition of pre-ischaemic conditioning in the mouse caudate brain slice by NMDA- or adenosine A1 receptor antagonists.  Eur J Pharmacology, 698, 322-329.

Prados, J., Alvarez, B., Howarth, J., Stewart, K., Gibson, C.L., Hutchinson, C.V., Young, A.M.J., & Davidson, C. (2013). Cue competition effects in the planarian. Animal Cognition, 16, 177-186.

Knight, S.R., Davidson C., Young, A.M.J., Gibson, C.L.  (2012) Allopregnanolone protects against dopamine-induced striatal damage following in vitro ischaemia via interaction at GABAA receptors.  J. Neuroendocrinology, 24, 1135-1143

Granger K.T., Prados, J., and Young, A.M.J. (2012)  Disruption of overshadowing and latent inhibition in high schizotypy individuals.  Behav. Brain Res..  233, 201-208.

Sood P., Idris N., Cole S., Grayson B., Neill J., Young A.M.J. (2011)  PD168077, a D4 receptor agonist, reverses object recognition deficits in rats: potential role for D4 receptor mechanisms in improving cognitive dysfunction in schizophrenia.  J. Psychopharmacol 25, 792-800.

Davidson C., Chauhan N.K., Knight S., Gibson C.L., Young A.M.J. (2011)  Modelling ischaemia in vitro: effects of temperature and glucose concentration on ischaemia-evoked dopamine release in mouse brain slices.  J. Neurosci Meth.  202, 165-172

Davidson C., Coomber B., Gibson, C.L., Young A.M.J. (2011) Effect of pre-ischaemic conditioning on hypoxic depolarization of dopamine efflux in the rat caudate brain slice measured in real-time with fast cyclic voltammetry.  Neurochemistry International 59, 714-721.

Davidson C., Prados J., Gibson C.L., Young A.M.J., Barnes D., Sherlock R., Hutchinson C.V. (2011)  Shedding light on photosensitive behaviour in brown planaria (Dugesia Tigrina).  Perception 40, 743-746

Young A.M.J. (2010) High performance liquid chromatography (HPLC).  In: (Stolerman IP, ed), Encyclopedia of Psychopharmacology.

Sood P., Cole S., Fraier D. and Young A.M.J. (2009). Evaluation of Metaquant microdialysis for measurement of absolute concentrations of amphetamine and dopamine in brain: a viable method for assessing pharmacokinetic profile of drugs in the brain.  J. Neurosci. Meth. 185, 39-44

Young A.M.J., Kumari V., Mehrotra R., Hemsley D.R., Andrew C., Sharma T., Williams S.C.R. and Gray J.A. (2005)  Disruption of learned irrelevance in acute schizophrenia in a novel continuous within-subject paradigm suitable for fMRI.  Behav. Brain Res., 156, 277-288

<Full list of publications>

Research

I am a member of the Behavioural Neuroscience Group in the Department of Neuroscience, Psychology and Behaviour, and allied to the Neuroscience & Behaviour theme in the College of Medicine, Biological Sciences and Psychology

Supervision

These are my main topics of research, and I would be keen to hear from any prospective students interested in any of these areas:

  • Neurochemical control of motivated behaviour and attention; links to addiction and schizophrenia
  • Neurochemical basis of conditioning and latent inhibition
  • Use of microdialysis and voltammetry for measuring brain chemistry
  • In vitro models of cerebral ischaemia
  • Analytical methods for measuring neurotransmitters and drugs
  • Pharmacokinetic/pharmacodynamic measurements of drugs in brain
  • Effects of drug use on attention, in relation to addiction and drug craving

Current researchers

  • PhD students : Ersin Yavas, Asmaa Al-Ali, Athar Hussein, Kate Peters

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Personal tutor weeks

March - April, 2019.

See schedule of bookable appointments

Open Office Hours

My Open Office  hours are :

  • Mon 4:00 to 5:00
  • Thurs 11:00 to 12:00

You do not need an appointment at these times: just turn up. 

If you cannot manage these times, please contact me, and we can fix an alternative time.

Research Day

Friday

Contact the Department

Department of Neuroscience, Psychology and Behaviour
University of Leicester
University Road
Leicester
LE1 7RH

T: +44 (0)116 252 2922
E: npbenquiries@le.ac.uk

Accessibility

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The University of Leicester is committed to equal access to our facilities. DisabledGo has detailed accessibility guides for the George Davies Centre, the Adrian Building and the Maurice Shock Medical Sciences Building.