Publications

  1. Collard L, Perez-Guaita D, Faraj BHA, Wood BR, Wallis R, Andrew PW, Hudson AJ (2017) Light Scattering By Optically-Trapped Vesicles Affords Unprecedented Temporal Resolution Of Lipid-Raft Dynamics. Sci Rep. 7(1):8589.
  2. Mitchell DA, Zhang Q, Voorhaar L, Haddleton DM, Herath S, Gleinich AS, Randeva HS, Crispin M, Lehnert H, Wallis R, Patterson S, Becer CR (2017) Manipulation of cytokine secretion in human dendritic cells using glycopolymers with picomolar affinity for DC-SIGN. Chem Sci. 8:6974-6980.
  3. Nan R, Furze CM, Wright DW, Gor J, Wallis R, Perkins SJ (2017) Flexibility in Mannan-Binding Lectin-Associated Serine Proteases-1 and -2 Provides Insight on Lectin Pathway Activation. Structure 25:364-375
  4. Yaseen S, Demopulos G, Dudler T, Yabuki M, Wood CL, Cummings WJ, Tjoelker LW, Fujita T, Sacks S, Garred P, Andrew P, Sim RB, Lachmann PJ, Wallis R, Lynch N, Schwaeble WJ (2017) Lectin pathway effector enzyme mannan-binding lectin-associated serine protease-2 can activate native complement C3 in absence of C4 and/or C2. FASEB J. 31:2210-2219.
  5. Pilecki B, Holm AT, Schlosser A, Moeller JB, Wohl AP, Zuk AV, Heumüller SE, Wallis R, Moestrup SK, Sengle G, Holmskov U, Sorensen GL (2016) Characterization of Microfibrillar-associated Protein 4 (MFAP4) as a Tropoelastin- and Fibrillin-binding Protein Involved in Elastic Fiber Formation. J Biol Chem. 291:1103-14.
  6. Marshall JE, Faraj BH, Gingras AR, Lonnen R, Sheikh MA, El-Mezgueldi M, Moody PC, Andrew PW, Wallis R (2015) The Crystal Structure of Pneumolysin at 2.0 Å Resolution Reveals the Molecular Packing of the Pre-pore Complex.Sci Rep. 2015 Sep 3;5:13293
  7. Venkatraman Girija, U, Furze, C.M. Gingras, A.R., Yoshizaki, T., Ohtani, K., Marshall, J.E., Wallis, A.K., Schwaeble, W.J., El-Mezgueldi, M., Mitchell, D.A., Moody, P.C.E., Wakamiya, N. and Wallis, R. (2015) Molecular basis of sugar recognition by collectin-K1 and the effects of mutations associated with 3MC syndrome. BMC Biology; 13:27
  8. Bidula S, Sexton DW, Yates M, Abdolrasouli A, Shah A, Wallis R, Reed A, Armstrong-James D, Schelenz S. (2015) H-ficolin binds Aspergillus fumigatus leading to activation of the lectin complement pathway and modulation of lung epithelial immune responses. Immunology:146:281-91
  9. Semblat JP, Ghumra A, Czajkowsky DM, Wallis R, Mitchell DA, Raza A, Rowe JA (2015) Identification of the minimal binding region of a Plasmodium falciparum IgM binding PfEMP1 domain. Mol Biochem Parasitol; 201:76-82.
  10. Risteli M, Ruotsalainen H, Bergmann U, Venkatraman Girija U, Wallis R, Myllylä R. (2014) Lysyl hydroxylase 3 modifies lysine residues to facilitate oligomerization of mannan-binding lectin. PLoS One.:e113498.
  11. Zhang, Q., Su, L., Collins, J., Chen, G., Wallis, R., Mitchell, D. A., Haddleton D. M., Becer, C. R. (2014) Dendritic Cell Lectin-Targeting Sentinel-like Unimolecular Glycoconjugates To Release an Anti-HIV Drug. J Am Chem Soc; 136: 4325-32
  12. Huang, J., Zhang, Q., Li, G. Z., Haddleton, D. M., Wallis, R., Mitchell, D., Heise, A., Becer, C. R. (2013) Synthetic glycopolypeptides as potential inhibitory agents for dendritic cells and HIV-1 trafficking. Macromol Rapid Commun; 34:1542-6
  13. Venkatraman Girija, U., Gingras, A. R., Marshall, J. E,, Panchal, R., Sheikh, M. A., Gál, P., Schwaeble, W. J., Mitchell, D. A., Moody, P. C. E. and Wallis, R. (2013) Structural basis of the C1q/C1s interaction and its central role in assembly of the C1 complex. Proc Natl Acad Sci U S A; 110, 13916-20
  14. Saeed, A., Baloch, K., Brown, R. J., Wallis, R., Chen, L., Dexter, L., McClure, C. P., Shakesheff, K., Thomson, B. J. (2013) MASP-1 is induced by hepatitis C virus infection and activates human hepatic stellate cells Clin Exp Immunol; 174, 265-73
  15. Zhang, Q., Collins, J., Anastasaki, A., Wallis, R., Mitchell, D. A., Becer C. R., Haddleton, D. M. (2013) Sequence-controlled multi-block glycopolymers to inhibit DC-SIGN-gp120 binding. Angew Chem Int Ed Engl; 52:4435-9.
  16. Schelenz, S., Kirchhof, N., Bidula, S., Wallis, R., Sexton, D.W. (2013) Opsonizing properties of rat ficolin-A in the defence against Cryptococcus neoformans. Immunobiology; 218:477-83.
  17. Beveridge, A. J., Wallis, R., Samani, N. J. (2012) A molecular dynamics study of C1r and C1s dimers: implications for the structure of the C1 complex. Proteins; 80:1987-97
  18. Ali, Y. M., Lynch, N. J., Haleem, K. S., Fujita, T., Endo, Y., Hansen, S., Holmskov, U., Takahashi, K., Stahl, G. L., Dudler, T., Girija U.V., Wallis, R, Kadioglu, A, Stover, C.M., Andrew, P. W., Schwaeble, W. J. (2012) The lectin pathway of complement activation is a critical component of the innate immune response to pneumococcal infection. PLoS Pathog; 8:e1002793.
  19. Millar, A., Phillips, A., Gor, J., Wallis, R., and Perkins, S. J. (2012).  Near planar solution structures of mannose-binding lectin provide insight on the activation of the lectin pathway of complement.  J Biol Chem, 287, 3930-45
  20. Gingras, A. R., Venkatraman Girija, U., Keeble, A.H., Panchal, R, Mitchell, D.A., Moody, P.C.E and Wallis, R. (2011).  Structural basis of mannan-binding lectin recognition by its associated serine protease MASP-1: implications for complement activation.  Structure, 19:1635-1643.
  21. Schwaeble W. J., Lynch N. J., Clark J. E., Marber M., Samani N.J., Ali Y. M., Dudler T., Parent B., Lhotta K., Wallis R., Farrar C. A., Sacks S., Lee H., Zhang M., Iwaki D., Takahashi M., Fujita T., Tedford C. E., Stover C. M. (2011)  Targeting of mannan-binding lectin-associated serine protease-2 confers protection from myocardial and gastrointestinal ischemia/reperfusion injury.  Proc Natl Acad Sci U S A 108:7523-8.
  22. Sim, R.W.B., Wallis, R.  (2011)  Surface properties: Immune attack on nanoparticles.  Nat Nanotechnol. 6:80-1.
  23. Venkatraman Girija, U., Mitchell, D. A., Rosher, S. and Wallis, R. (2011) Carbohydrate recognition and complement activation by rat ficolin-B. Eur J Immunol 41:214-23
  24. Ilyas, R., Wallis, R., Soilleux, E. J., Townsend, P., Zehnder, D., Tan, B. K., Sim, R. B., Lehnert, H., Randeva, H., Mitchell, D. (2011).  High glucose disrupts oligosaccharide recognition function via competitive inhibition: a potential mechanism for immune dysregulation in diabetes mellitus. Immunobiology. 216:126-31.
  25. Remzi, B. C., Gibson, M., Geng, J. Ilyas, R., Mitchell, D. A., Wallis, R., Haddleton, D. M. (2010) High affinity glycopolymer Binding to Human DC-SIGN and Disruption of DC-SIGN.  J Am Chem Soc. 132:15130-2.
  26. Venkatraman Girija, U., Furze, C., Toth, J., Schwaeble, W. J., Mitchell, D. A., Keeble, A. H., Wallis, R. (2010).  Engineering novel complement activity into a pulmonary-surfactant protein.  J Biol Chem, 285:10546-10552
  27. Thomsen, T., Moeller, J. B., Schlosser, A., Sorensen, G. L., Moestrup, S. K., Palaniyar, N., Wallis, R., Mollenhauer, J., Holmskov, U. (2010) The recognition unit of FIBCD1 organizes into a noncovalently linked tetrameric structure and uses a hydrophobic funnel (S1) for acetyl group recognition. J Biol Chem, 285:1229-1238.
  28. Wallis, R., Mitchell, D. A., Schmid, R., Schwaeble, W. J., and Keeble, A. H. (2010) Paths reunited: activation of the classical and lectin pathways of complement, Immunobiology, 215:1-11.
  29. Phillips, A. E., Toth, J., Dodds, A. W., Venkatraman Girija, U., Furze, C., Pala, E., Sim, R. B., Reid, K. B. M., Schwaeble, W. J., Schmid, R., Keeble, A. H., and Wallis, R. (2009) Analogous Interactions in Initiating Complexes of the Classical and Lectin Pathways of Complement, J Immunol, 182: 7708-7717.
  30. Farber, K., Cheung, G., Mitchell, D., Wallis, R., Weihe, E., Schwaeble, W., and Kettenmann, H. (2009) C1q, the recognition subcomponent of the classical pathway of complement, drives microglial activation, J Neurosci Res 87, 644-652.
  31. Wallis, R., Krarup, A., and V., G. U. (2008) Structure and function of Ficolins, MBLs and MASPs, in Molecular Aspects of Innate and Adaptive Immunity (Reid, K. B. M., and Sim, R. B., Eds.), pp 147-156, RSC Publishing, Cambridge.
  32. Wallis, R., and Lynch, N. J. (2007) Biochemistry and genetics of the collectins, in Collagen-related lectins in innate immunity (Kilpatrick, D. C., Ed.), pp 33-56, Research Signpost, Kerala, India.
  33. Wallis, R., Dodds, A. W., Mitchell, D. A., Sim, R. B., Reid, K. B., and Schwaeble, W. J. (2007) Molecular Interactions between MASP-2, C4, and C2 and Their Activation Fragments Leading to Complement Activation via the Lectin Pathway, J Biol Chem 282, 7844-7851.
  34. Wallis, R. (2007) Interactions between mannose-binding lectin and MASPs during complement activation by the lectin pathway, Immunobiology 212, 289-299.
  35. Krarup, A., Wallis, R., Presanis, J. S., Gal, P., and Sim, R. B. (2007) Simultaneous activation of complement and coagulation by MBL-associated serine protease 2, PLoS ONE 2, e623.
  36. Girija, U. V., Dodds, A. W., Roscher, S., Reid, K. B., and Wallis, R. (2007) Localization and Characterization of the Mannose-Binding Lectin (MBL)-Associated-Serine Protease-2 Binding Site in Rat Ficolin-A: Equivalent Binding Sites within the Collagenous Domains of MBLs and Ficolins, J Immunol 179, 455-462.
  37. Geng, J., Mantovani, G., Tao, L., Nicolas, J., Chen, G., Wallis, R., Mitchell, D. A., Johnson, B. R., Evans, S. D., and Haddleton, D. M. (2007) Site-directed conjugation of "clicked" glycopolymers to form glycoprotein mimics: binding to mammalian lectin and induction of immunological function, J Am Chem Soc 129, 15156-15163.
  38. Van den Steen, P. E., Van Aelst, I., Hvidberg, V., Piccard, H., Fiten, P., Jacobsen, C., Moestrup, S. K., Fry, S., Royle, L., Wormald, M. R., Wallis, R., Rudd, P. M., Dwek, R. A., and Opdenakker, G. (2006) The hemopexin and O-glycosylated domains tune gelatinase B/MMP-9 bioavailability via inhibition and binding to cargo receptors, J Biol Chem 281, 18626-18637.
  39. Cordes, F. S., Kraiczy, P., Roversi, P., Simon, M. M., Brade, V., Jahraus, O., Wallis, R., Goodstadt, L., Ponting, C. P., Skerka, C., Zipfel, P. F., Wallich, R., and Lea, S. M. (2006) Structure-function mapping of BbCRASP-1, the key complement factor H and FHL-1 binding protein of Borrelia burgdorferi, Int J Med Microbiol 296, 177-184.
  40. Beuron, F., Dreveny, I., Yuan, X., Pye, V. E., McKeown, C., Briggs, L. C., Cliff, M. J., Kaneko, Y., Wallis, R., Isaacson, R. L., Ladbury, J. E., Matthews, S. J., Kondo, H., Zhang, X., and Freemont, P. S. (2006) Conformational changes in the AAA ATPase p97-p47 adaptor complex, EMBO J 25, 1967-1976.
  41. Arnold, J. N., Wallis, R., Willis, A. C., Harvey, D. J., Royle, L., Dwek, R. A., Rudd, P. M., and Sim, R. B. (2006) Interaction of mannan binding lectin with alpha2 macroglobulin via exposed oligomannose glycans: a conserved feature of the thiol ester protein family?, J Biol Chem 281, 6955-6963.
  42. Wallis, R., Lynch, N. J., Roscher, S., Reid, K. B., and Schwaeble, W. J. (2005) Decoupling of carbohydrate binding and MASP-2 autoactivation in variant mannose-binding lectins associated with immunodeficiency, J Immunol 175, 6846-6851.
  43. Cordes, F. S., Roversi, P., Kraiczy, P., Simon, M. M., Brade, V., Jahraus, O., Wallis, R., Skerka, C., Zipfel, P. F., Wallich, R., and Lea, S. M. (2005) A novel fold for the factor H-binding protein BbCRASP-1 of Borrelia burgdorferi, Nat Struct Mol Biol 12, 276-277.
  44. Yuan, X., Simpson, P., McKeown, C., Kondo, H., Uchiyama, K., Wallis, R., Dreveny, I., Keetch, C., Zhang, X., Robinson, C., Freemont, P., and Matthews, S. (2004) Structure, dynamics and interactions of p47, a major adaptor of the AAA ATPase, p97, EMBO J 23, 1463-1473.
  45. Wallis, R., Shaw, J. M., Uitdehaag, J., Chen, C. B., Torgersen, D., and Drickamer, K. (2004) Localization of the serine protease-binding sites in the collagen-like domain of mannose-binding protein: indirect effects of naturally occurring mutations on protease binding and activation, J Biol Chem 279, 14065-14073.
  46. Chen, C. B., and Wallis, R. (2004) Two mechanisms for mannose-binding protein modulation of the activity of its associated serine proteases, J Biol Chem 279, 26058-26065.
  47. Wallis, R. (2003) Structural basis for mannose-binding protein function in innate immunity, in Immunobiology of Carbohydrates (Wong, Y. C., and Arsequell, G., Eds.), pp 34-45, Landes Bioscience, Texas, USA.
  48. Feinberg, H., Uitdehaag, J. C., Davies, J. M., Wallis, R., Drickamer, K., and Weis, W. I. (2003) Crystal structure of the CUB1-EGF-CUB2 region of mannose-binding protein associated serine protease-2, EMBO J 22, 2348-2359.
  49. Wallis, R. (2002) Dominant effects of mutations in the collagenous domain of mannose-binding protein, J Immunol 168, 4553-4558.
  50. Wallis, R. (2002) Structural and functional aspects of complement activation by mannose-binding protein, Immunobiology 205, 433-445.
  51. Porcelli, I., de Leeuw, E., Wallis, R., van den Brink-van der Laan, E., de Kruijff, B., Wallace, B. A., Palmer, T., and Berks, B. C. (2002) Characterization and membrane assembly of the TatA component of the Escherichia coli twin-arginine protein transport system, Biochemistry 41, 13690-13697.
  52. Chen, C. B., and Wallis, R. (2001) Stoichiometry of complexes between mannose-binding protein and its associated serine proteases. Defining functional units for complement activation, J Biol Chem 276, 25894-25902.
  53. Wallis, R., and Dodd, R. B. (2000) Interaction of mannose-binding protein with associated serine proteases: effects of naturally occurring mutations, J Biol Chem 275, 30962-30969.
  54. Wallis, R. (2000) C-Type lectins and collectins, in Oligosaccharides in chemistry and biology - a comprehensive handbook (Ernst, B., Sinay, P., and Hart, G., Eds.), pp 597-611, Wiley-VCH, Weinheim.
  55. Heise, C. T., Nicholls, J. R., Leamy, C. E., and Wallis, R. (2000) Impaired secretion of rat mannose-binding protein resulting from mutations in the collagen-like domain, J Immunol 165, 1403-1409.
  56. Drickamer, K., Taylor, M., and Wallis, R. (2000) Sugar binding and innate immunity, Wellcome Trust Review 9, 38-40.
  57. Wallis, R., and Drickamer, K. (1999) Molecular determinants of oligomer formation and complement fixation in mannose-binding proteins, J Biol Chem 274, 3580-3589.
  58. Wallis, R., and Cheng, J. Y. (1999) Molecular defects in variant forms of mannose-binding protein associated with immunodeficiency, J Immunol 163, 4953-4959.
  59. Wallis, R., Leung, K. Y., Osborne, M. J., James, R., Moore, G. R., and Kleanthous, C. (1998) Specificity in protein-protein recognition: conserved Im9 residues are the major determinants of stability in the colicin E9 DNase-Im9 complex, Biochemistry 37, 476-485.
  60. Pommer, A. J., Wallis, R., Moore, G. R., James, R., and Kleanthous, C. (1998) Enzymological characterization of the nuclease domain from the bacterial toxin colicin E9 from Escherichia coli, Biochem J 334, 387-392.
  61. Dennis, C. A., Videler, H., Pauptit, R. A., Wallis, R., James, R., Moore, G. R., and Kleanthous, C. (1998) A structural comparison of the colicin immunity proteins Im7 and Im9 gives new insights into the molecular determinants of immunity-protein specificity, Biochem J 333, 183-191.
  62. Wallis, R., and Drickamer, K. (1997) Asymmetry adjacent to the collagen-like domain in rat liver mannose-binding protein, Biochem J 325, 391-400.
  63. Osborne, M. J., Wallis, R., Leung, K. Y., Williams, G., Lian, L. Y., James, R., Kleanthous, C., and Moore, G. R. (1997) Identification of critical residues in the colicin E9 DNase binding region of the Im9 protein, Biochem J 323, 823-831.
  64. Wallis, R., Reilly, A., Moore, G. R., James, R., and Kleanthous, C. (1995) A kinetic analysis of the interaction between a DNase and its inhibitor protein,  (Geisow, M. J., and Epton, R., Eds.), pp 277-280, Mayflower Worldwide, Kingswinford, UK.
  65. Wallis, R., Moore, G. R., James, R., and Kleanthous, C. (1995) Protein-protein interactions in colicin E9 DNase-immunity protein complexes. 1. Diffusion-controlled association and femtomolar binding for the cognate complex, Biochemistry 34, 13743-13750.
  66. Wallis, R., Leung, K. Y., Pommer, A. J., Videler, H., Moore, G. R., James, R., and Kleanthous, C. (1995) Protein-protein interactions in colicin E9 DNase-immunity protein complexes. 2. Cognate and noncognate interactions that span the millimolar to femtomolar affinity range, Biochemistry 34, 13751-13759.
  67. Wallis, R., Reilly, A., Barnes, K., Abell, C., Campbell, D. G., Moore, G. R., James, R., and Kleanthous, C. (1994) Tandem overproduction and characterisation of the nuclease domain of colicin E9 and its cognate inhibitor protein Im9, Eur J Biochem 220, 447-454.
  68. Osborne, M. J., Lian, L. Y., Wallis, R., Reilly, A., James, R., Kleanthous, C., and Moore, G. R. (1994) Sequential assignments and identification of secondary structure elements of the colicin E9 immunity protein in solution by homonuclear and heteronuclear NMR, Biochemistry 33, 12347-12355.
  69. Kleanthous, C., Wallis, R., Reilly, A., Osborne, M., Lian, L.-Y., Moore, G. R., and James, R. (1994) Structure and function of a bacterial toxin inhibitor,  (Freer, J., Ed.), pp 230 - 240, Gustav Fischer, Stuttgart.
  70. Wallis, R., Reilly, A., Rowe, A., Moore, G. R., James, R., and Kleanthous, C. (1992) In vivo and in vitro characterization of overproduced colicin E9 immunity protein, Eur J Biochem 207, 687-695.
  71. Wallis, R., Moore, G. R., Kleanthous, C., and James, R. (1992) Molecular analysis of the protein-protein interaction between the E9 immunity protein and colicin E9, Eur J Biochem 210, 923-930.
  72. James, R., Curtis, M. D., Wallis, R., Osborne, M., Kleanthous, C., and Moore, G. R. (1992) Specificity determinants for the interaction of colicin E9 with its immunity protein, in NATO ASI Series H (James, R., Lazdunski, C., and Pattus, F., Eds.), pp 181

Share this page:

Contact Details

Department of Molecular and Cell Biology
Henry Wellcome Building
Lancaster Road
Leicester
LE1 7RH (Postal)

LE1 7HB (Sat Nav/Online maps)

T:  +44(0)116 229 7038
F:  +44(0)116 229 7123
MolCellBiol@le.ac.uk

Accessibility

DisabledGo logo

The University of Leicester is committed to equal access to our facilities. DisabledGo has a detailed accessibility guide for the Henry Wellcome Building.

Redfearn Lecture 2017

To Be Confirmed