Sue Shackleton

Tel: +44 (0)116 229 7058Sue Shackleton

Email: ss115@le.ac.uk

Personal details

  • Degree: Biochemistry BA, University of Oxford (1991)
  • Postgraduate Research Assistant in the laboratory of Professor Ann Harris, Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford (1991-1993)
  • DPhil: University of Oxford (1996)
  • Postdoctoral Research Assistant in the laboratory of Professor Jean-Louis Carpentier, Department of Morphology, University of Geneva, Switzerland (1996-1998)
  • Postdoctoral Research Fellow in the laboratory of Professor Richard Trembath, Department of Genetics, University of Leicester (1998-2005)
  • Research Councils UK Research Fellow, Department of Biochemistry, University of Leicester (2005-2010)
  • Lecturer, University of Leicester (2010 - 2013)
  • Senior Lecturer, University of Leicester (2013 - )

Publications

Publications

Selected publications

  • Patel JT, Bottrill A, Prosser SL, Jayaraman S, Straatman K, Fry AM, Shackleton S. Mitotic phosphorylation of SUN1 loosens its connection with the nuclear lamina while the LINC complex remains intact. (2014) Nucleus 5, 462-473.
  1. Meinke, P., Mattioli, E., Haque, F., Antoku, S., Columbaro, M., Straatman, K.R., Worman, H.J., Gundersen, G.G., Lattanzi, G., Wehnert, M., Shackleton, S. Muscular Dystrophy-Associated SUN1 and SUN2 Variants Disrupt Nuclear-Cytoskeletal Connections and Myonuclear Organization. (2014) PLoS Genetics 10, e1004605.
  • Watkins, R.J., Patil, R., Goult, B.T., Thomas, M.G., Gottlob, I. and Shackleton, S. A novel interaction between FRMD7 and CASK – evidence for a causal role in idiopathic infantile nystagmus. (2013) Human Molecular Genetics 22, 2105-2118.
  • Sylvius, N., Bonne, G., Straatman, K., Reddy, T., Gant, T. and Shackleton, S. MicroRNA expression profiling in patients with lamin A/C-associated muscular dystrophy. (2011) FASEB J. 25, 3966-3978.
  • Haque F, Mazzeo, D., Patel, J.T., Smallwood, D.T., Ellis, J.A., Shannahan, C.M. and Shackleton, S. Mammalian SUN protein networks at the inner nuclear membrane and their role in laminopathy disease processes. (2010) Journal of Biological Chemistry 285, 3487-98.
  • Haque, F., Lloyd, D, Smallwood, D., Dent, C., Shanahan, C., Fry, A., Trembath, R. and Shackleton, S. SUN1 interacts with nuclear lamin A and cytoplasmic nesprins to provide a physical connection between the nuclear lamina and the cytoskeleton (2006) Molecular and Cellular Biology 26, 3738-3751.
  • Shackleton, S., Smallwood, D.T., Clayton, P., Wilson, L.C., Agarwal, A. K., Garg, A. and Trembath, R.C. Compound heterozygous ZMPSTE24 mutations reduce prelamin A processing and result in a severe progeroid phenotype (2005) Journal of Medical Genetics, 42, e36.
  • Lloyd, D., Trembath, R., Shackleton, S. A novel interaction between lamin A and SREBP1: implications for partial lipodystrophy (2002) Human Molecular Genetics 11, 769-777.
  • Shackleton, S., Lloyd, D., Jackson, S., Evans, R., Niermeijer, M., Singh, B., Schmidt, H., Brabant, G., Kumar, S., Durrington, P., Gregory, S., O’Rahilly, S., Trembath, R. The LMNA gene encoding lamin A/C is mutated in partial lipodystrophy (2000) Nature Genetics 24, 152-156.

Research

Nuclear envelope function and its role in human disease, with a focus on the nucleo-cytoskeletal linker proteins, SUN1 and SUN2. Current projects include:

  • investigating the role of SUN proteins in myonuclear positioning during muscle development
  • identifying muscle disease-associated mutations in SUN1 and SUN2 and investigating their effects on muscle differentiation and myonuclear positioning
  • characterising mitotic SUN protein phosphorylation and its role in nuclear envelope breakdown

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Contact Details

Department of Molecular and Cell Biology
Henry Wellcome Building
Lancaster Road
Leicester
LE1 7RH (Postal)

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T:  +44(0)116 229 7038
F:  +44(0)116 229 7123
MolCellBiol@le.ac.uk

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Redfearn Lecture 2017

To Be Confirmed