John Schwabe

Tel: +44 (0)116 229 7030
Email: john.schwabe@le.ac.uk

Personal details

BA(Hons) Biochemistry, University College, University of Oxford (1983-1987).
PhD Trinity Hall, University of Cambridge & MRC-Lab of Molecular Biology, Cambridge UK (1987-1991).
Postdoctoral fellow MRC-Lab of Molecular Biology (1992-1994).
Staff Scientist, Salk Institute for Biological Studies, La Jolla, California USA (1995-1997).
Adjunct Associate Professor, Salk Institute for Biological Studies, La Jolla, California USA (1997-1999)
Group Leader / Senior Scientist MRC-Lab of Molecular Biology, Cambridge UK (1997-2006)
Professor of Structural Biology, University of Leicester UK (2006- )
Head of Department of Biochemistry (2010-2015)
Head of Department of Molecular and Cell Biology (2015- 2017)

Publications

list of publications

Research

Structural Biology: NMR Spectroscopy & X-ray Crystallography
Molecular mechanisms of the regulation of gene expression
Nuclear receptors and their role in metabolism, development and disease

Research summary

link to my research page

Current research interests

The current major interest in the group is understanding the structure and function of HDAC-containing corepressor complexes. This work is supported by a Wellcome Trust Senior Investigator Award. These complexes play an important role in the regulation of development, differentiation, cancer and homeostasis.

In addition, the group has a long-standing interest in the molecular mechanisms of transcriptional regulation by nuclear receptors. Nuclear receptors are important regulators of gene expression and are major drug targets. Our understanding of the mechanism of the ligand-regulated switch has been greatly enhanced by studies of the structure and dynamics of nuclear receptors.

In addition to these core research areas, the group is also involved in a number of collaborative projects with an emphasis on proteins and complexes implicated in various cancers.