John Schwabe: Publications

  1. Itoh, T., Fairall, L., Muskett, F. W., Milano, C. P., Watson, P. J., Arnaudo, N., Saleh, A., Millard, C.J., El-Mezgueldi, M., Martino, F., Schwabe, J.W.R. Structural and functional characterization of a cell cycle associated HDAC1/2 complex reveals the structural basis for complex assembly and nucleosome targeting. Nucleic Acids Res. (2015). doi:10.1093/nar/gkv068
  2. Nettleship, J.E., Watson, P.J., Rahman-Huq, N., Fairall, L., Posner, M.G., Upadhyay, A.,
 Reddivari, Y., Chamberlain, J.M.G., Kolstoe, S.E., Bagby,S., Schwabe,J.W.R., and Owens,R.J. Transient Expression in HEK 293 Cells: An Alternative 
to E. coli for the Production of Secreted and Intracellular Mammalian Proteins. Insoluble Proteins: Methods and Protocols, Methods in Molecular Biology, vol. 1258, Chapter 11, 209-222. DOI 10.1007/978-1-4939-2205-5_11, © Springer Science+Business Media New York 2015.
  3. Jamaladdin, S., Kelly, R.D.W., O'Regan, L., Dovey, O.M., Hodson, G.E., Millard, C.J., Portolano, N., Fry, A.M., Schwabe, J.W.R., Cowley, S.M. Histone deacetylase (HDAC) 1 and 2 are essential for accurate cell division and the pluripotency of embryonic stem cells. Proc Natl Acad Sci USA (2014) 111, 9840–9845.
  4. Millard, C.J., Fairall, L., Schwabe, J.W.R. Towards an understanding of the structure and function of MTA1. Cancer Metastasis Rev (2014) 33, 857-867.
  5. Portolano, N., Watson, P.J., Fairall, L., Millard, C.J., Milano, C.P., Song, Y., Cowley, S.M., Schwabe, J.W.R. Recombinant Protein Expression for Structural Biology in HEK 293F Suspension Cells: A Novel and Accessible Approach. J Vis Exp (2014) e51897–e51897.
  6. Schoenmakers, N., Moran, C., Campi, I., Agostini, M., Bacon, O., Rajanayagam, O., Schwabe, J.W.R., Bradbury, S., Barrett, T., Geoghegan, F., Druce, M., Beck-Peccoz, P., O'Toole, A., Clark, P., Bignell, M., Lyons, G., Halsall, D., Gurnell, M., Chatterjee, K. A novel albumin gene mutation (R222I) in familial dysalbuminemic hyperthyroxinemia. J Clin Endocrinol Metab (2014) 99, E1381–6.
  7. Evans, S. E., Goult, B. T., Fairall, L., Jamieson, A. G., Ko Ferrigno, P., Ford, R., Schwabe, J. W. & Wagner, S. D. (2014). The Ansamycin Antibiotic, Rifamycin SV, Inhibits BCL6 Transcriptional Repression and Forms a Complex with the BCL6-BTB/POZ Domain. PloS One (2014) 9, e90889.
  8. Millard, C.J., P.J. Watson, I. Celardo, Y. Gordiyenko, S.M. Cowley, C.V. Robinson, L. Fairall, and J.W.R. Schwabe. Class I HDACs share a common mechanism of regulation by inositol phosphates. Molecular Cell (2013) 51, 57-67.
  9. Millard, C. J., Watson, P. J., Fairall, L., & Schwabe, J. W. R. An evolving understanding of nuclear receptor coregulator proteins. Journal of Molecular Endocrinology (2013) 51, T23–36.
  10. Weber, K., Harper, N., Schwabe, J., & Cohen, G. M. (2013). BIM-Mediated Membrane Insertion of the BAK Pore Domain Is an Essential Requirement for Apoptosis. Cell Reports (2013) 5, 409–420.
  11. Dhani, D.K., B.T. Goult, G.M. George, D.T. Rogerson, D.A. Bitton, C.J. Miller, J.W.R. Schwabe, and K. Tanaka. Mzt1/Tam4, a fission yeast MOZART1 homologue, is an essential component of the γ-tubulin complex and directly interacts with GCP3Alp6. Mol Biol Cell (2013) 24, 3337-3349.
  12. Watson, P.J., L. Fairall, G.M. Santos and J.W.R. Schwabe. Structure of HDAC3 bound to corepressor and inositol tetraphosphate. Nature (2012) 481, 335-340.
  13. Dickens, L.S., R.S. Boyd, R. Jukes-Jones, M.A. Hughes, G.L. Robinson, L. Fairall, J.W.R. Schwabe, K. Cain and M. MacFarlane. A Death Effector Domain Chain DISC Model Reveals a Crucial Role for Caspase-8 Chain Assembly in Mediating Apoptotic Cell Death. Molecular Cell, (2012) 47, 291-305.
  14. Watson, P.J.,L. Fairall, and J.W.R. Schwabe. Nuclear hormone receptor co-repressors: Structure and function. Mol Cell Endocrinol, (2012) 348, 440-449.
  15. Craxton, A, M. Butterworth, N. Harper, L. Fairall, J.W.R. Schwabe, A. Ciechanova and G.M. Cohen. NOXA, a sensor of proteasome integrity, is degraded by 26S proteasomes by an ubiquitin-independent pathway that is blocked by MCL-1. Cell Death Diff, (2012) 19, 1424-1434.
  16. Bochukova, E., N. Schoenmakers, M. Agostini, E. Schoenmakers, O. Rajanayagam, J.M. Keogh, E. Henning, J. Reinemund, E. Gevers, M. Sarri, K. Downes, A. Offiah, A. Albanese, D. Halsall, J.W.R. Schwabe, M. Bain, K. Lindley, F. Muntoni, F. Vargha Khadem, M.Dattani, I.S. Farooqi, M. Gurnell, and V.K. Chatterjee. A mutation in the thyroid hormone receptor alpha gene. N Engl J Med, (2012) 366, 243-249
  17. Calkin, A, B.T. Goult, L. Zhang, L. Fairall, C. Hong, J.W.R. Schwabe* and P. Tontonoz*. FERM-dependent E3 ligase recognition: an evolutionarily-conserved mechanism for targeted degradation of lipoprotein receptors. Proc Natl Acad Sci USA, (2011) 108, 20107-20112. *Co-corresponding authors
  18. Zhang, L., L. Fairall, B.T. Goult, A.C. Calkin, C. Hong, C.J. Millard, P. Tontonoz, and J.W.R. Schwabe, The IDOL-UBE2D complex mediates sterol-dependent degradation of the LDL receptor. Genes Dev, (2011) 25, 1262-1274.
  19. Oberoi, J., L. Fairall, P. Watson, J.-C. Yang, Z. Czimmerer, T. Kampmann, B. Goult, J. Greenwood, J. Gooch, B.C. Kallenberger, L. Nagy, D. Neuhaus, and J.W.R. Schwabe, Structural basis for the assembly of the SMRT/NCoR core transcriptional repression machinery. Nat Struct Mol Biol, (2011) 18, 177-84.
  20. Santos, G.M., L. Fairall, and J.W.R. Schwabe, Negative regulation by nuclear receptors: a plethora of mechanisms. Trends in endocrinology and metabolism: TEM, (2011) 22, 87-93.
  21. Szanto, A., B.L. Balint, Z.S. Nagy, E. Barta, B. Dezso, A. Pap, L. Szeles, S. Poliska, M. Oros, R.M. Evans, Y. Barak, J. Schwabe, and L. Nagy, STAT6 transcription factor is a facilitator of the nuclear receptor PPARγ-regulated gene expression in macrophages and dendritic cells. Immunity, (2010) 33, 699-712.
  22. Schoenmakers, E., et al., Mutations in the selenocysteine insertion sequence-binding protein 2 gene lead to a multisystem selenoprotein deficiency disorder in humans. J Clin Invest, (2010) 120, 4220-35.
  23. Castanet, M., U. Mallya, M. Agostini, E. Schoenmakers, C. Mitchell, S. Demuth, F.L. Raymond, J. Schwabe, M. Gurnell, and V.K. Chatterjee, Maternal isodisomy for chromosome 9 causing homozygosity for a novel FOXE1 mutation in syndromic congenital hypothyroidism. J Clin Endocrinol Metab, (2010) 95, 4031-6.
  24. Tadokoro, R., T. Bunch, J. Schwabe, I. Hughes, and J. Murphy, Comparison of the molecular consequences of different mutations at residue 754 and 690 of the androgen receptor and androgen insensitivity syndrome phenotype. Clin Endocrinol (Oxf), (2008) 71, 253-60.
  25. Løvås, K., I. McFarlane, H. Nguyen, S. Curran, J. Schwabe, D. Halsall, R. Bernhardt, A. Wallace, and V. Chatterjee, A novel CYP11B2 gene mutation in an Asian family with aldosterone synthase deficiency. J Clin Endocrinol Metab, (2008) 94, 914-9.
  26. Itoh, T., L. Fairall, K. Amin, Y. Inaba, A. Szanto, B. Balint, L. Nagy, K. Yamamoto, and J. Schwabe, Structural basis for the activation of PPARgamma by oxidized fatty acids. Nat Struct Mol Biol, (2008) 15, 924-31.
  27. Jaaskelainen, J., A. Deeb, J.W. Schwabe, N.P. Mongan, H. Martin, and I.A. Hughes, Human androgen receptor gene ligand-binding-domain mutations leading to disrupted interaction between the N- and C-terminal domains. J Mol Endocrinol, (2006) 36, 361-8.
  28. Benoit, G., A. Cooney, V. Giguere, H. Ingraham, M. Lazar, G. Muscat, T. Perlmann, J.-P. Renaud, J. Schwabe, F. Sladek, M.-J. Tsai, and V. Laudet, International Union of Pharmacology. LXVI. Orphan nuclear receptors. Pharmacol Rev, (2006) 58, 798-836.
  29. Agostini, M., et al., Non-DNA binding, dominant-negative, human PPARgamma mutations cause lipodystrophic insulin resistance. Cell Metab, (2006) 4, 303-11.
  30. Semple, R.K., A. Meirhaeghe, A.J. Vidal-Puig, J.W. Schwabe, D. Wiggins, G.F. Gibbons, M. Gurnell, V.K. Chatterjee, and S. O'Rahilly, A dominant negative human peroxisome proliferator-activated receptor (PPAR){alpha} is a constitutive transcriptional corepressor and inhibits signaling through all PPAR isoforms. Endocrinology, (2005) 146, 1871-82.
  31. Codina, A., J.D. Love, Y. Li, M.A. Lazar, D. Neuhaus, and J.W.R. Schwabe, Structural insights into the interaction and activation of HDAC3 by nuclear receptor co-repressors. Proc Natl Acad Sci U S A, (2005) 102, 6009-6014.
  32. Schwabe, J.W. and S.A. Teichmann, Nuclear receptors: the evolution of diversity. Sci STKE, (2004) 2004, pe4.
  33. Nagy, L. and J.W. Schwabe, Mechanism of the nuclear receptor molecular switch. Trends Biochem Sci, (2004) 29, 317-24.
  34. Hannema, S.E., I.S. Scott, J. Hodapp, H. Martin, N. Coleman, J.W. Schwabe, and I.A. Hughes, Residual activity of mutant androgen receptors explains wolffian duct development in the complete androgen insensitivity syndrome. J Clin Endocrinol Metab, (2004) 89, 5815-22.
  35. Codina, A., G. Benoit, J.T. Gooch, D. Neuhaus, T. Perlmann, and J.W. Schwabe, Identification of a novel co-regulator interaction surface on the ligand binding domain of Nurr1 using NMR footprinting. J Biol Chem, (2004) 279, 53338-45.
  36. Agostini, M., M. Gurnell, D.B. Savage, E.M. Wood, A.G. Smith, O. Rajanayagam, K.T. Garnes, S.H. Levinson, H.E. Xu, J.W. Schwabe, T.M. Willson, S. O'Rahilly, and V.K. Chatterjee, Tyrosine agonists reverse the molecular defects associated with dominant-negative mutations in human peroxisome proliferator-activated receptor gamma. Endocrinology, (2004) 145, 1527-38.
  37. Kallenberger, B.C., J.D. Love, V.K. Chatterjee, and J.W. Schwabe, A dynamic mechanism of nuclear receptor activation and its perturbation in a human disease. Nat Struct Mol Biol, (2003) 10, 136-40.
  38. Benko, S., J.D. Love, M. Beladi, J.W. Schwabe, and L. Nagy, Molecular determinants of the balance between co-repressor and co-activator recruitment to the retinoic acid receptor. J Biol Chem, (2003) 278, 43797-806.
  39. Ariyoshi, M. and J.W. Schwabe, A conserved structural motif reveals the essential transcriptional repression function of Spen proteins and their role in developmental signaling. Genes Dev, (2003) 17, 1909-20.
  40. Mongan, N.P., J. Jaaskelainen, K. Green, J.W. Schwabe, N. Shimura, M. Dattani, and I.A. Hughes, Two de novo mutations in the AR gene cause the complete androgen insensitivity syndrome in a pair of monozygotic twins. J Clin Endocrinol Metab, (2002) 87, 1057-61.
  41. Love, J.D., J.T. Gooch, S. Benko, C. Li, L. Nagy, V.K. Chatterjee, R.M. Evans, and J.W. Schwabe, The structural basis for the specificity of retinoid-X receptor-selective agonists: new insights into the role of helix H12. J Biol Chem, (2002) 277, 11385-91.
  42. Clayton, G.M., S.Y. Peak-Chew, R.M. Evans, and J.W. Schwabe, The structure of the ultraspiracle ligand-binding domain reveals a nuclear receptor locked in an inactive conformation. Proc Natl Acad Sci U S A, (2001) 98, 1549-54.
  43. Wentworth, J.M., M. Agostini, J. Love, J.W. Schwabe, and V.K. Chatterjee, St John's wort, a herbal antidepressant, activates the steroid X receptor. J Endocrinol, (2000) 166, R11-6.
  44. Schwabe, J.W.R., Art and architecture of proteins. Tends Genet., (2000) 16, 235.
  45. Love, J.D., J.T. Gooch, L. Nagy, V.K. Chatterjee, and J.W. Schwabe, Transcriptional repression by nuclear receptors: mechanisms and role in disease. Biochem Soc Trans, (2000) 28, 390-6.
  46. Gurnell, M., J.M. Wentworth, M. Agostini, M. Adams, T.N. Collingwood, C. Provenzano, P.O. Browne, O. Rajanayagam, T.P. Burris, J.W. Schwabe, M.A. Lazar, and V.K. Chatterjee, A dominant-negative peroxisome proliferator-activated receptor gamma (PPARgamma) mutant is a constitutive repressor and inhibits PPARgamma-mediated adipogenesis. J Biol Chem, (2000) 275, 5754-9.
  47. Fairall, L. and J.W.R. Schwabe, DNA binding by transcription factors, in Transcription factors, J. Locker, Editor 2000, BIOS Scientific Publishers: Oxford. p. 65-84.
  48. Nagy, L., H.Y. Kao, J.D. Love, C. Li, E. Banayo, J.T. Gooch, V. Krishna, K. Chatterjee, R.M. Evans, and J.W. Schwabe, Mechanism of corepressor binding and release from nuclear hormone receptors. Genes Dev, (1999) 13, 3209-16.
  49. Gurnell, M., O. Rajanayagam, M. Agostini, R.J. Clifton-Bligh, T. Wang, P.M. Zelissen, F. van der Horst, A. van de Wiel, E. Macchia, A. Pinchera, J.W. Schwabe, and V.K. Chatterjee, Three novel mutations at serine 314 in the thyroid hormone beta receptor differentially impair ligand binding in the syndrome of resistance to thyroid hormone. Endocrinology, (1999) 140, 5901-6.
  50. Barroso, I., M. Gurnell, V.E. Crowley, M. Agostini, J.W. Schwabe, M.A. Soos, G.L. Maslen, T.D. Williams, H. Lewis, A.J. Schafer, V.K. Chatterjee, and S. O'Rahilly, Dominant negative mutations in human PPARgamma associated with severe insulin resistance, diabetes mellitus and hypertension. Nature, (1999) 402, 880-3.
  51. Schwabe, J.W., C. Rodriguez-Esteban, and J.C. Izpisua Belmonte, Limbs are moving: where are they going? Trends Genet, (1998) 14, 229-35.
  52. Rodriguez-Esteban, C., J.W. Schwabe, J.D. Pena, D.E. Rincon-Limas, J. Magallon, J. Botas, and J.C. Belmonte, Lhx2, a vertebrate homologue of apterous, regulates vertebrate limb outgrowth. Development, (1998) 125, 3925-34.
  53. Rhodes, D. and J.W. Schwabe, Signal transduction: fast lane to transcriptional activation. Curr Biol, (1998) 8, R765-7.
  54. Choo, Y. and J.W. Schwabe, All wrapped up. Nat Struct Biol, (1998) 5, 253-5.
  55. Schwabe, J.W., C. Rodriguez-Esteban, J. De La Pena, A.T. Tavares, J.K. Ng, E.M. Banayo, B. Foys, B. Eshelman, J. Magallon, R. Tam, and J.C. Izpisua-Belmonte, Outgrowth and patterning of the vertebrate limb. Cold Spring Harb Symp Quant Biol, (1997) 62, 431-5.
  56. Schwabe, J.W. and D. Rhodes, Linkers made to measure. Nat Struct Biol, (1997) 4, 680-3.
  57. Schwabe, J.W., The role of water in protein-DNA interactions. Curr Opin Struct Biol, (1997) 7, 126-34.
  58. Schulman, I.G., C. Li, J.W. Schwabe, and R.M. Evans, The phantom ligand effect: allosteric control of transcription by the retinoid X receptor. Genes Dev, (1997) 11, 299-308.
  59. Rodriguez-Esteban*, C., J.W. Schwabe*, J. De La Pena, B. Foys, B. Eshelman, and J.C. Belmonte, Radical fringe positions the apical ectodermal ridge at the dorsoventral boundary of the vertebrate limb. Nature, (1997) 386, 360-6. *Joint first authors
  60. Li, C., J.W. Schwabe, E. Banayo, and R.M. Evans, Coexpression of nuclear receptor partners increases their solubility and biological activities. Proc Natl Acad Sci U S A, (1997) 94, 2278-83.
  61. Fairall, L. and J.W.R. Schwabe, Zinc finger DNA-binding motifs, in Encyclopedia of molecular biology and molecular medicine 1997, VCH: Weinheim.
  62. Schwabe, J.W.R., How protein handles DNA. Nature Structural Biology, (1996) 3, 495-496.
  63. Schwabe, J.W., Transcriptional control: how nuclear receptors get turned on. Curr Biol, (1996) 6, 372-4.
  64. Rhodes, D., J.W. Schwabe, L. Chapman, and L. Fairall, Towards an understanding of protein-DNA recognition. Philos Trans R Soc Lond B Biol Sci, (1996) 351, 501-9.
  65. Schwabe, J.W.R. and L. Fairall, Zinc finger DNA-binding motifs, in The Encyclopaedia of Molecular Biology, Meyers, Editor 1995, VCH. p. 979-984.
  66. Schwabe, J.W., L. Chapman, and D. Rhodes, The oestrogen receptor recognizes an imperfectly palindromic response element through an alternative side-chain conformation. Structure, (1995) 3, 201-13.
  67. Klug, A. and J.W. Schwabe, Protein motifs 5. Zinc fingers. Faseb J, (1995) 9, 597-604.
  68. Schwabe, J.W.R. and D. Rhodes, Protein-nucleic acid interactions, in Encyclopaedia of Molecular Biology, Kendrew, Editor 1994, Blackwell Science Ltd.: Oxford. p. 893-900.
  69. Schwabe, J.W. and A. Klug, Zinc mining for protein domains. Nat Struct Biol, (1994) 1, 345-9.
  70. Luisi, B.F., J.W. Schwabe, and L.P. Freedman, The steroid/nuclear receptors: from three-dimensional structure to complex function. Vitam Horm, (1994) 49, 1-47.
  71. Travers, A.A. and J.W.R. Schwabe, Spurring on transcription? Current Biology, (1993) 3, 898-900.
  72. Schwabe, J.W.R. and A.A. Travers, What is evolution playing at? Current Biology, (1993) 3, 628-630.
  73. Schwabe, J.W.R., L. Chapman, J.T. Finch, D. Rhodes, and D. Neuhaus, DNA recognition by the oestrogen receptor: from solution to the crystal. Structure, (1993) 1, 187-204.
  74. Schwabe, J.W., L. Fairall, L. Chapman, J.T. Finch, R.N. Dutnall, and D. Rhodes, The cocrystal structures of two zinc-stabilized DNA-binding domains illustrate different ways of achieving sequence-specific DNA recognition. Cold Spring Harb Symp Quant Biol, (1993) 58, 141-7.
  75. Schwabe, J.W., L. Chapman, J.T. Finch, and D. Rhodes, The crystal structure of the estrogen receptor DNA-binding domain bound to DNA: how receptors discriminate between their response elements. Cell, (1993) 75, 567-78.
  76. Fairall, L., J.W. Schwabe, L. Chapman, J.T. Finch, and D. Rhodes, The crystal structure of a two zinc-finger peptide reveals an extension to the rules for zinc-finger/DNA recognition. Nature, (1993) 366, 483-7.
  77. Schwabe, J.W.R., Distinctly different… or really much the same? Current Biology, (1992) 2, 237-239.
  78. Schwabe, J.W.R., DNA between the sheets. Current Biology, (1992) 2, 661-663.
  79. Neuhaus, D., Y. Nakaseko, J.W. Schwabe, and A. Klug, Solution structures of two zinc-finger domains from SWI5 obtained using two-dimensional 1H nuclear magnetic resonance spectroscopy. A zinc-finger structure with a third strand of beta-sheet. J Mol Biol, (1992) 228, 637-51.
  80. Klug, A., D. Neuhaus, J. Schwabe, Y. Nakeseko, L. Fairall, K. Nagai, and D. Rhodes, The structures of two classes of zinc-finger domains and their modes of interaction with DNA. Science and Technology in Japan, (1992) 33, 60-80.
  81. Schwabe, J.W. and D. Rhodes, Beyond zinc fingers: steroid hormone receptors have a novel structural motif for DNA recognition. Trends Biochem Sci, (1991) 16, 291-6.
  82. Rhodes, D. and J.W. Schwabe, Structural biology. Complex behaviour. Nature, (1991) 352, 478-9.
  83. Schwabe, J.W., D. Neuhaus, and D. Rhodes, Solution structure of the DNA-binding domain of the oestrogen receptor. Nature, (1990) 348, 458-61.
  84. Loughman, B.C., R.G. Ratcliffe, and J.W.R. Schwabe, Galactose metabolism in Zea mays root tissues observed by 31P-NMR spectroscopy. Plant Sci., (1989) 59, 11-23.
  85. Barford, D., J.W. Schwabe, N.G. Oikonomakos, K.R. Acharya, J. Hajdu, A.C. Papageorgiou, J.L. Martin, J.C. Knott, A. Vasella, and L.N. Johnson, Channels at the catalytic site of glycogen phosphorylase b: binding and kinetic studies with the beta-glycosidase inhibitor D-gluconohydroximo-1,5-lactone N-phenylurethane. Biochemistry, (1988) 27, 6733-41.

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