John Schwabe: Research Summary

Current Research Interests

The current major interest in the group is understanding the structure and function of HDAC-containing corepressor complexes. This work is supported by a Wellcome Trust Senior Investigator Award. These complexes play an important role in the regulation of development, differentiation, cancer and homeostasis.

In addition, the group has a long standing interest in the molecular mechanisms of transcriptional regulation by nuclear receptors. Nuclear receptors are important regulators of gene expression and are major drug targets. Our understanding of the mechanism of the ligand regulated switch has been greatly enhanced by studies of the structure and dynamics of nuclear receptors.

In addition to these core research areas, the group is also involved in a number of collaborative projects with an emphasis on proteins and complexes implicated in various cancers.

Recent Research Funding

  • Wellcome Trust Senior Investigator Award (HDAC complexes)
  • EU Research Training Network (Nuclear receptors)
  • BBSRC Project Grant (Specificity of HDAC1 complexes)
  • Wellcome Trust Equipment Grant (Anaerobic crystallisation facility)
  • Wellcome Trust Project Grant (IDOL: The E3 ligase for the LDL receptor)
  • Wellcome Trust Programme Grant (Transcriptional Repression Complexes)

Links to:

John Schwabe Research Highlights

John Schwabe Group Members

John Schwabe Publications

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Contact Details

Department of Molecular and Cell Biology

T: +44(0)116 229 7038

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