Publications

  1. Wheeler S, Haberkant P, Bhardwaj M, Tongue P, Ferraz MJ, Halter D, Sprong H, Schmid R, Aerts JMFG, Sullo N, Sillence DJ. (2019) Cytosolic glucosylceramide regulates endolysosomal function in Niemann-Pick type C disease. Neurobiology of Disease , 127, 242-252. link
  2. Schmid R, Evans RJ. (2019) ATP-Gated P2X Receptor Channels: Molecular Insights into Functional Roles. Annual Review of Physiology , 81, 43-62. link
  3. Fryatt AG, Dayl S, Stavrou A, Schmid R, Evans RJ. (2019) Organization of ATP-gated P2X1 receptor intracellular termini in apo and desensitized states. Journal of General Physiology , 151(2), 146-155. link
  4. Wheeler S, Schmid R, Sillence DJ. (2019) Lipid–Protein Interactions in Niemann–Pick Type C Disease: Insights from Molecular Modelling. International Journal of Molecular Sciences , 20(3), E717. link
  5. Huo H, Fryatt AG, Farmer LK, Schmid R, Evans RJ. (2018) Mapping the binding site of the P2X receptor antagonist PPADS reveals the importance of orthosteric site charge and the cysteine-rich head region. Journal of Biological Chemistry, 293(33), 12820-12831. link
  6. Allsopp RC, Dayl S, Dayel AB, Schmid R, Evans RJ. (2018) Mapping the Allosteric Action of Antagonists A740003 and A438079 Reveals a Role for the Left Flipper in Ligand Sensitivity at P2X7 Receptors. Molecular Pharmacology, 93(5), 553-562. link
  7. Kapetanaki SM, Burton MJ, Basran J, Uragami C, Moody PCE, Mitcheson JS, Schmid R, Davies NW, Dorlet P, Vos MH, Storey NM, Raven E. (2018) A mechanism for CO regulation of ion channels. Nature Communications, 9(1), 907. link
  8. Allsopp RC, Dayl S, Schmid R, Evans RJ. (2017) Unique residues in the ATP gated human P2X7 receptor define a novel allosteric binding pocket for the selective antagonist AZ10606120. Scientific Reports, 7(1), 725. link
  9. Fryatt AG, Dayl S, Cullis PM, Schmid R, Evans RJ. (2016) Mechanistic insights from resolving ligand-dependent kinetics of conformational changes at ATP-gated P2X1R ion channels. Scientific Reports, 6, 32918. link
  10. Burton MJ, Kapetanaki SM, Chernova T, Jamieson AG, Dorlet P, Santolini J, Moody PC, Mitcheson JS, Davies NW, Schmid R, Raven EL, Storey NM. (2016) A heme-binding domain controls regulation of ATP-dependent potassium channels. Proceedings of the National Academy of Sciences , 113(14), 3785-3790. link
  11. Winter A, Schmid R, Bayliss R. (2015) Structural Insights into Separase Architecture and Substrate Recognition through computational modelling of Caspase-like and Death domains. PLoS Computational Biology, 11(10), e10045489. link
  12. Farmer LK, Schmid R, Evans RJ. (2015) Use of Chimeras, Point Mutants, and Molecular Modeling to Map the Antagonist-binding Site of 4,4',4,4‴-(Carbonylbis-(imino-5,1,3-benzenetriylbis(carbonylimino)))tetrakisbenzene-1,3-disulfonic Acid (NF449) at P2X1 Receptors for ATP.Journal of Biological Chemistry, 290, 1559-69. link
  13. Graciotti M, Alam, M, Solyakov L, Schmid R, Burley G, Bottrill AR, Doerig C, Cullis P, Tobin AB. (2014) Malaria Protein Kinase CK2 (PfCK2) Shows Novel Mechanisms of Regulation.. PLoS One, 9(3), e85391. link
  14. Pegoraro M, Noreen S, Bhutani S, Tsolou A, Schmid R, Kyriacou CP, Tauber E. (2014) Molecular Evolution of a Pervasive Natural Amino-Acid Substitution in Drosophila cryptochrome. PLoS One, 9(1), e86483. link
  15. Popovics P, Jin L, Kamil LN, Morgan K, Millar RP, Schmid R, Blindauer CA, Stewart AJ. (2014) A canonical EF-loop directs Ca2+-sensitivity in phospholipase C-η2. Journal of Cellular Biochemistry, 115, 557-565. link
  16. Schmid R, Grellscheid SN, Ehrmann I, Dalgliesh C, Danilenko M, Paronetto MP, Pedrotti S, Grellscheid D, Dixon RJ, Sette C, Eperon IC, Elliott DJ. (2013) The splicing landscape is globally reprogrammed during male meiosis. Nucleic Acids Research, 41 10170-84. link
  17. Shafiq MI, Steinbrecher T, Schmid R. (2012) FASCAPLYSIN as a Specific Inhibitor for CDK4: Insights from Molecular Modelling. PLoS One, 7(8), e42612. link
  18. Barnett JP, Millard A, Ksibe AZ, Scanlan DJ, Schmid R, Blindauer CA. (2012) Mining genomes of marine cyanobacteria for elements of zinc homeostasis. Frontiers in Microbiology, 3, 142. link
  19. Roberts JA, Allsopp RC, El Ajouz S, Vial C, Schmid R, Young MT, Evans RJ. (2012) Agonist binding evokes extensive conformational changes in the extracellular domain of the ATP-gated human P2X1 receptor ion channel Proceedings of the National Academy of Science U.S.A., 109, 4663-4667. link
  20. Rieck B, Tourigny DS, Crosatti M, Schmid R, Kochar M, Harrison EM, Ou HY, Turton JF Rajakumar K. (2012) Acinetobacter Insertion Sequence ISAba11 Belongs to a Novel Family That Encodes Transposases with a Signature HHEK Motif. Applied and Environmental Microbiology, 78, 471-480. link
  21. Allsopp RC, El Ajouz S, Schmid R, Evans RJ. (2011) Cysteine Scanning Mutagenesis (Residues Glu(52)-Gly(96)) of the Human P2X1 Receptor for ATP: Mapping Agonist Binding and Channel Gating Journal of Biological Chemistry, 286, 29207-29217. link
  22. Blindauer CA, Schmid R. (2010) Cytosolic metal handling in plants: determinants for zinc specificity in metal transporters and metallothioneins. Metallomics, 2, 510-529. link
  23. Wallis R, Mitchell DA, Schwaeble WJ, Schmid R, Keeble AH. (2010) Paths reunited: activation of the classical and lectin pathways of complement. Immunobiology, 215, 1-11. link
  24. Grant-Downton R, Le Trionnaire G, Schmid R, Rodriguez-Enriquez J, Hafidh S, Mehdi S, Twell D, Dickinson H. (2009) MicroRNA and tasiRNA diversity in mature pollen of Arabidopsis thaliana. BMC Genomics,10, 643. link
  25. Cai H, Sale S, Schmid R, Britton RG, Brown K, Steward WP, Gescher AJ. (2009) Flavones as colorectal cancer chemopreventive agents - phenol-O-methylation enhances efficacy. Cancer Prevention Research, 2, 743-750. link
  26. Phillips AE, Toth J, Dodds AW, Venkatraman Girija U, Furze C, Pala E, Sim RB, Reid KBM, Schwaeble WJ, Schmid R, Keeble AH, Wallis R. (2009) Analogous Interactions in Initiating Complexes of the Classical and Lectin Pathways of Complement. Journal of Immunology, 182, 7708-7717. link
  27. Schmid R, Blaxter ML. (2009) EST processing: from trace to sequence. Methods in Molecular Biology, 533, 189-220. link
  28. Schmid R. (2008) Pitfalls of using out of date databases - Comment on Guo et al. and Guo et al. Journal of Theoretical Biology, 255, 262. link
  29. Menz B, Sester M, Koebernick K, Schmid R, Burgert H-G. (2008) Structural analysis of the adenovirus type 2 E3/19K protein using mutagenesis and a panel of conformation-sensitive monoclonal antibodies. Molecular Immunology, 46, 16-26. link
  30. Wasmuth JW, Schmid R, Hedley A, Blaxter ML. (2008) On the extent and origins of genic novelty in the phylum Nematoda. PLoS Neglected Tropical Diseases, 2(7), e258. link
  31. Schmid R, Blaxter ML. (2008) annot8r: GO, EC and KEGG annotation of EST datasets. BMC Bioinformatics, 9, 180. link
  32. Chalmers IW, McArdle AJ, Coulson RMR, Wagner MA, Schmid R, Hirai H, Hoffmann KF. (2008) Developmentally regulated expression, alternative splicing and distinct sub-groupings in members of the Schistosoma mansoni venom allergen-like (SmVAL) gene family. BMC Genomics,9, 89. link
  33. Leszczyszyn OI, Schmid R, Blindauer CA. (2007) Toward a property/function relationship for metallothioneins: Histidine coordination and unusual cluster composition in a zinc-metallothionein from plants. Proteins-Structure Function and Bioinformatics, 68, 922-935. link
  34. Roberts SJ, Stewart AJ, Schmid R, Blindauer CA, Bond SR, Sadler PJ, Farquharson C. (2005) Probing the substrate specificities of human PHOSPHO1 and PHOSPHO2. Biochimica Biophysica Acta, 1752, 73-82. link
  35. Parkinson J, Mitreva M, Whitton C, Thomson M, Daub J, Martin J, Schmid R, Hall N, Waterston RH, McCarter JP, Blaxter ML. (2004) A Transcriptomic Analysis of the Phylum Nematoda. Nature Genetics, 36, 1259-1267. link
  36. Schmid R, Gerloff DL. (2004) Functional properties of the alternative NADH:ubiquinone oxidoreductase from E. coli through comparative 3-D modelling. FEBS Letters, 578, 163-168. link
  37. Parkinson J, Anthony A, Wasmuth J, Schmid R, Hedley A, Blaxter M. (2004) PartiGene – constructing partial genomes. Bioinformatics, 20, 1398-1404. link
  38. Borrelly GPM, Blindauer CA, Schmid R, Butler CS, Cooper CE, Harvey I, Sadler PJ, Robinson NJ. (2004) A novel copper site in a cyanobacterial metallochaperone (Accelerated Publication). Biochemical Journal, 378, 293-297. link
  39. Parkinson J, Whitton C, Schmid R, Thomson M, Blaxter M. (2004) NEMBASE: a resource for parasitic nematode ESTs. Nucleic Acid Research, 32, D427-D430. link
  40. Stewart AJ, Schmid R, Blindauer CA, Paisey SJ, Farquharson C. (2003) Comparative modelling of human PHOSPHO1 reveals a new group of phosphatases within the HAD superfamily. Protein Engineering, 16, 889-895. link
  41. Hucke O, Schmid R, Labahn A. (2002) Exploring the primary electron acceptor (QA)-site of the bacterial reaction center from Rhodobacter sphaeroides : binding mode of vitamin K derivatives. European Journal of Biochemistry, 269, 1096-1108. link
  42. Schmid R, Labahn A. (2000) Temperature and free energy dependence of the direct charge recombination rate from the secondary quinone in bacterial reaction centers from Rhodobacter sphaeroides. Journal of Physical Chemistry B, 104, 2928-2936. link
  43. Schmid R. (2000) Untersuchung von Elektronentransferreaktionen in photosynthetischen Reaktionszentren. Logos Verlag Berlin, ISBN 978-3-89722-195-6. link
  44. Schmid R, Goebel F, Warnecke A, Labahn A. (1999) Synthesis and redox potentials of methylated vitamin K derivatives. Journal of the Chemical Society Perkin Transactions 2, 6, 1199-1202. link
  45. Labahn A, Schmid R, Okamura MY, Feher G (1998) Temperature dependence of the direct charge recombination from QB-· to D+ in bacterial reaction centers of Rhodobacter sphaeroides. Photosynthesis: Mechanisms and Effects, Vol. II, G. Garab (Ed.); Kluwer Academic Publishers, Netherlands, 829-832.
  46. Schmid R, Labahn A. (1998) The influence of quinone structure on quinone binding to the QA-site in bacterial reaction centers from Rhodobacter sphaeroides. Photosynthesis: Mechanisms and Effects, Vol. III, G. Garab (Ed.); Kluwer Academic Publishers, Netherlands, 877-880.

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