Paul Glynn

Tel: 0116 294 4656     Email: pg8@le.ac.uk

Background

I joined the former department of Cell Physiology & Pharmacology as an honorary lecturer in 2010. I’m enjoying teaching after a career at the lab bench in research-only institutes.

Research Interests

Physiology, pharmacology and pathology, particularly of the nervous system.
My aim is to contribute to departmental research projects in these areas.

Research Achievements

* Discovered MADM, a novel protease now known as ADAM10/ alpha-secretase.

* Discovered the biochemical and physiological functions of NTE - the protein target for organophosphate-induced neuropathy. NTE maintains eukaryotic phospholipid homeostasis and optimum function of the constitutive secretory pathway. It is essential for pre-natal mammalian development and integrity of axons in the adult central nervous system.

Publications

Chantry, A, Gregson, N, Glynn, P (1989) A novel metalloproteinase associated with brain myelin membranes: isolation and characterisation. J. Biol. Chem. 264, 21603-21607.
Howard, L, Lu, X, Mitchell, S, Griffiths, S, Glynn, P (1996) Molecular cloning of MADM: a catalytically-active distintegrin-metalloprotease expressed in various cell types. Biochem. J. 317, 45-50.
Lush, MJ, Li, Y, Read, DJ, Willis, AC, Glynn, P (1998) Neuropathy target esterase and a Drosophila neurodegeneration-associated mutant protein contain a novel domain conserved from bacteria to man. Biochem. J. 332, 1-4.
Van Tienhoven, M, Atkins, J, Li, Y, Glynn, P (2002) Human neuropathy target esterase catalyses hydrolysis of membrane lipids. J. Biol. Chem. 277, 20942-20948.
Zaccheo, O, Dinsdale, D, Meacock, PA, Glynn, P (2004) Neuropathy target esterase and its yeast homologue degrade phosphatidylcholine to glycerophosphocholine in living cells. J. Biol. Chem. 279, 24024-24033.
Moser, M, Li, Y, Vaupel, K, Kretzschmar, D Kluge, R, Glynn, P, Buttner, R (2004) Placental failure and impaired vasculogenesis result in embryonic lethality for neuropathy target esterase-deficient mice. Mol. Cell. Biol. 24, 1667-1679.
Read, DJ, Li, Y, Chao, MV, Cavanagh, JB, Glynn, P (2009) Neuropathy target esterase is required for adult vertebrate axon maintenance. J. Neuroscience 29, 11594-11600.

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E: MolCellBiol@le.ac.uk

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