Raj Patel

Personal Details

Rajnikant PatelLecturer
Raj Patel DepartmentMolecular and Cell Biology
Telephone: +44 (0)116 229 7068
Emailrp31@le.ac.uk
Web Links:

Qualifications

  • B.Pharm (Hons) School of Pharmacy, University of London (1980)
  • PhD University of Aston in Birmingham (1985)
  • Postdoctoral Research Assistant, Department of Physiology, UCL (1987)
  • Wellcome Trust Junior Fellow UCL (1993)
  • Lecturer Department of Molecular and Cell Biology (formerly Biochemistry)(2000)

Teaching

  • Biochemistry
  • Molecular and Cell Biology
  • Cancer Biology

Publications

  1. 2010 Hagemann, C., Weigelin, B., Schommer, S., Schulze, M., Al-Jomah, N., Anacker, J., Gerngras, S., Kühnel, S., Kessler, A. F., Polat, B., Ernestus, R-I., Patel, R. and Hamilton- Vince, G. The cohesin-interacting protein, precocious dissociation of sisters 5A/sister chromatid cohesion protein 112, is up-regulated in human astrocytic tumors. Int. J. Mol. Med. 27, 39-51.
  2. 2008 Hagemann, C., Stojic, J., Gerngras, S., Kuhnel, S., Said, S. M., Patel, R., Kammerer, U., Vordermark, D., Roosen, K. and Hamilton-Vince, G. Expression analysis of the autosomal recessive primary microcephaly genes MCPH1 (Microcephalin) and MCPH5 (ASPM, abnormal spindle- like microcephaly associated) in human malignant gliomas. Oncology Reports 20, 301-308
  3. 2004 Mistry, P., Deacon, K., Mistry, S., Blank, J. & Patel, R. NF-kB promotes survival during mitotic cell cycle arrest. J Biol. Chem. 279, 1482-1490.
  4. 2003 Hagemann, C., Patel, R. and Blank, J. MEKK3 interacts with the PA28 gamma regulatory subunit of the proteasome. Biochem. J. 73, 71-79.
  5. 2003 Deacon, K., Mistry, P., Chernoff, J., Blank, J. and Patel, R. p38 MAP kinase mediates cell death and p21-activated kinase (PAK) mediates cell survival during chemotherapeutic drug-induced mitotic arrest. Mol. Biol. Cell. 14, 2071-2087.
  6. 2002 Burdon, D., Patel, R., Challiss, R. A. J. and Blank, J. L. Growth inhibition by the M3 muscarinic acetylcholine receptor. Biochem. J. 367, 549-559.
  7. 2000 Kawahara, H., Philipova, R., Yokosawa, H., Patel, R., Tanaka, K. and Whitaker, M. Inhibiting proteasome activity causes overreplication of DNA and blocks entry into mitosis in sea urchin embryos. J. Cell Sci. 113, 2659-2670
  8. 1999 Patel, R., Holt, M., Philipova, R., Moss, S., Hidaka, H., Schulman, H. & Whitaker, M. Calcium/calmodulin-dependent phosphorylation and activation of human cdc25-C at the G2/M-phase transition in HeLa cells. J.Biol.Chem. 274, 7958-7968.
  9. 1998 Patel, R., Bartosch, B. and Blank, J. L. p21WAF1 is dynamically associated with JNK in human T-lymphocytes during cell cycle progression. J.Cell Sci. 111, 2247-2255.
  10. 1998 Torok, K., Wilding, M., Groigno, L., Patel, R. and Whitaker, M. Imaging the spatial dynamics of calmodulin activation during mitosis. Curr.Biol. 8, 692-699.
  11. 1997 Patel, R., Wright, E. & Whitaker, M. Caffeine overide of the S-phase checkpoint in sea urchin embryos. Zygote, 5, 127-138.
  12. 1996 Wilding, M., Wright, E. M., Patel, R., Ellis-Davis, G. and Whitaker, M. Local perinuclear calcium signals associated with mitosis-entry in early sea urchin embryos. J. Cell Biol., 135, 191-199.
  13. 1994 Kramer, I, M., Patel, R., Spargo, D. & Riley, P. Commitment to growth inhibition by TGF 1 occurs in late S/G2. J. Cell Sci., 107, 3469-3475
  14. 1991 Edgecombe, M., Patel, R. & Whitaker, M.J. A cyclin-abundance cycle-independent p34cdc2 tyrosine phosphorylation cycle in early sea urchin embryos. EMBO J., 10, 3769-3775.
  15. 1991 Patel, R., & Whitaker, M.J. Okadaic acid suppresses calcium regulation of mitosis onset in sea urchin embryos. Cell Regulation 2, 391-402
  16. 1990 Whitaker, M.J. & Patel, R. Calcium and cell cycle control. Development 108, 525-542
  17. 1989 Patel, R., Twigg, J., Sheppard, B. & Whitaker, M.J. Calcium, cyclin and cell cycle control in sea urchin embryos. in Developmental Biology. UCLA Symposia, New series, vol. 125 NY:Liss. pp. 21-35.
  18. 1989 Patel, R., Twigg, J., Crossley, I., Golsteyn, R. & Whitaker, M.J. Calcium-induced chromatin condensation and cyclin phosphorylation during chromatin condensation cycles in ammonia-activated sea urchin eggs. J. Cell Sci. Suppl. 12 'The Cell Cycle', 129-144.
  19. 1988 Twigg, J., Patel, R. & Whitaker, M.J. Translational control of InsP3-induced chromatin condensation during the early cell cycles of sea urchin embryos. Nature 332, 366-369.

Research

Regulation of Cell Division and Cell Death.

We are interested in how a mammalian cell segregates its chromosomes into two identical sets at mitosis and the consequences for the cell if it fails to do so. The accurate segregation of chromosomes during anaphase is essential for the accurate transfer of genetic information during each cell division. Mistakes in this process result in the generation of cells with either extra or missing chromosomes (aneuploidy), which then have the potential to form cancer cells.

Our research focuses on two specific areas and we use biochemical, molecular and cell biology techniques and advanced microscopy in our studies.

It is known that the cohesin complex forms a ring-like structure that holds the sister chromatids together following DNA replication. The core components of the cohesin complex include Smc1 and Smc3 (members of the structural maintenance of chromosomes family of ATPases), scc1 (a member of the kleisin family of proteins) and scc3 (SA1 and SA2 in vertebrates). However, less is known about the cohesin regulators, such as Wings Apart-like 1 (Wap1) and Pds5 (Precocious Dissociation of Sisters), and how they control the loading and removal of cohesin from chromatin during mammalian cell division. We are currently studying the mechanism of the cohesin regulators.

Our second research interest is focused on the study of the mitotic checkpoint (or spindle assembly checkpoint) and the relationship between activation of the mitotic checkpoint and cell survival/cell death. Many anti-microtubule, anti-cancer drugs such as Taxol (Paclitaxel), which is used clinically in the treatment of breast and ovarian cancer, activate the spindle checkpoint and cause the cell to arrest in mitosis. The mitotically-arrested cells eventually undergo programmed cell death or apoptosis, although the mechanism remains unclear. Therefore, our current studies are aimed at understanding the biochemical events that determine the fate of the cell in response to the activation of the spindle checkpoint.

Supervision

  • Current PhD students: Omeed Darweesh, Atiqah Sulaiman

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Contact Details

Department of Molecular and Cell Biology

T: +44(0)116 229 7038
E: MolCellBiol@le.ac.uk

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