Dr Noel Davies

Tel: +44 (0)116 229 7138

Email: nwd@le.ac.uk

Personal details

I was awarded my PhD from the University of St Andrews in 1986 and have been a Senior Lecturer at the University of Leicester since 2004.

My CV

  • 1999-2004: Lecturer, University of Leicester
  • 1991-1999: Royal Society University Research Fellow, University of Leicester
  • 1988-1991: Postdoctoral Research Associate, University of Leicester
  • 1987-1988: Max-Planck Research Fellow, Munich
  • 1986-1987: Royal Society European Exchange Fellow, MPI, Munich

Publications

Lörinczi, E, Helliwell, M, Finch, A, Stansfeld, PJ, Davies, NW, Mahaut-Smith, MP, Muskett, F & Mitcheson, JS (2016) Calmodulin regulates hEAG1 channels through interactions of the eag-domain with the cyclic nucleotide binding homology domain. J Biol Chem 291(34):17907-17918.

Burton, MJ, Kapetanaki SM, Chernova, T, Jamieson AG, Dorlet, P, Santolini, J, Moody, PCE, Mitcheson, JS, Davies, NW, Schmid, R, Raven, EL & Storey, NM (2016). Heme-binding domain controls regulation of ATP-dependent potassium channels. PNAS 113(14): 3785–3790

Panhwar, F, Rainbow, RD, Jackson, R & Davies, NW (2015). Ca2+ dependent but PKC independent signalling mediates UTP induced contraction of rat mesenteric arteries. J Smooth Musc Res 51:58-69.

Brignell, JL, Perry, MD, Nelson, CP, Willets, JM, Challiss, RAJ & Davies, NW (2015). Steady-state modulation of voltage-gated K+ channels in rat arterial smooth muscle by cyclic AMP-dependent protein kinase and protein phosphatase 2B. PLOS ONE 10.1371/journal.pone.0121285

Rainbow, RD, Parker, AM & Davies, NW (2011). Protein kinase C-independent inhibition of arterial smooth muscle K+ channels by a diacylglycerol analogue. Brit. J. Pharmacol. 163:845-856.

Nelson CP, Rainbow RD, Brignell JL, Perry MD, Willets JM, Davies NW, Standen NB & Challiss RA. (2011). Principal role of adenylyl cyclase 6 in K+ channel regulation and vasodilator signalling in vascular smooth muscle cells. Cardiovasc Res. 91:694-702.

Rainbow RD, Norman RI, Everitt DE, Brignell JL, Davies NW and Standen NB. (2009). Endothelin I and angiotensin II inhibit arterial voltage-gated K+ channels through different PKC isoenzymes. Cardiovascular Research 83:493-500.

Nelson CP, Willets JM, Davies NW, Challiss RAJ and Standen NB. (2008). Visualizing the temporal effects of vascoconstrictors on PKC translocation and Ca2+ signaling in single resistance arterial smooth muscle cells. American Journal of Physiology - Cell Physiology 295:C1590-1601.

Hayabuchi Y, Willars GB, Standen NB and Davies NW. (2008). Insulin-like growth factor-I inhibits rat arterial KATP channels through PI 3-kinase. Biochemical and Biophysical Research Communications 374:742-746.

El-Rachkidy RG, Davies NW and Andrew PW. (2008). Pneumolysin generates multiple conductance pores in the membrane of nucleated cells. Biochemical and Biophysical Research Communications 368:786-792

Rainbow RD, Hardy MEL, Standen NB and Davies NW. (2006). Glucose reduces endothelin inhibition of voltage-gated potassium channels in rat arterial smooth muscle cells. Journal of Physiology 575(3): 833-844.

Rainbow RD, Norman RI, Hudman D, Davies NW and Standen NB (2005). Reduced effectiveness of HMR 1098 in blocking cardiac sarcolemmal KATP channels during metabolic stress. Journal of Molecular and Cellular Cardiology 39(4):637-646

Rainbow RD, Lodwick D, Hudman D, Davies NW, Norman RI and Standen NB. (2004). SUR2A C-terminal fragments reduce KATP currents and ischaemic tolerance of rat cardiac myocytes. Journal of Physiology 577(3): 785-794.

Rainbow RD, James M, Hudman D, Al Johi M, Singh H, Watson PJ, Ashmole I, Davies NW, Lodwick D and Norman RI. (2004). Proximal C-terminal domain of sulphonylurea receptor 2A interacts with pore-forming Kir6 subunits in KATP channels. Biochemical Journal 379(1):173-81.

Rodrigo GC, Davies NW and Standen N.B. (2004). Diazoxide causes early activation of cardiac sarcolemmal KATP channels during metabolic inhibition by an indirect mechanism. Cardiovascular Research 61/3: 570-579.

Lippiat JD, Standen NB and Davies NW. (2003). Properties of BKCa channels formed by bicistronic expression of hSloa and b1-4 subunits in HEK293 cells. Journal of Membrane Biology 192: 141-148.

Lawrence CL, Rainbow RD, Davies NW and Standen NB. (2002). Effect of metabolic inhibition on glimepiride block of native and cloned cardiac sarcolemmal KATP channels. British Journal of Pharmacology 136: 746-752.

Hayabuchi Y, Standen NB and Davies NW. (2001). Angiotensin II inhibits and alters kinetics of voltage gated K+ channels of rat arterial smooth muscle. American Journal of Physiology 281:H2480-H2489.

Hayabuchi Y, Davies NW and Standen NB. (2001). Angiotensin II inhibits rat arterial KATP channels by inhibiting steady-state PKA activity and activating PKCe. Journal of Physiology 530(2),193-205.

So I, Ashmole I, Davies NW, Sutcliffe MJ and Stanfield PR. (2001). The K+ channels signature sequence of murine Kir2.1: mutations that affect microscopic gating but not ionic selectivity. Journal of Physiology 531(1), 37-49.

Lewis CJ, Davies NW and Evans RJ. (2001). Permeability and single channel properties of mesenteric, basilar and septal (coronary) artery smooth muscle P2X receptors. Drug Development Research 52: 164-169.

Lippiat JD, Standen NB and Davies NW. (2000). A residue in the intracellular vestibule of the pore is critical for gating and permeation in Ca2+-activated K+ (BKCa) channels. Journal of Physiology 529, 131-138.

Kamishima T, Davies NW and Standen NB. (2000). Mechanisms that regulate [Ca2+]i following depolarization in rat systemic arterial smooth muscle cells. Journal of Physiology 522, 285-295.

Lippiat JD, Standen NB and Davies NW. (1998). Block of cloned BKCa channels (rSlo) expressed in HEK 293 cells by N-methyl D-glucamine. (1998) Pflügers Archiv 436(5): 810-812.

Barrett-Jolley R and Davies NW. (1997). Kinetic analysis of the inhibitory effect of glibenclamide on KATP channels of mammalian skeletal muscle. Journal of Membrane Biology, 155(3), 257-262.

Davies NW, McKillen HC, Stanfield PR and Standen NB. (1996). A rate theory model for Mg2+ block of ATP-dependent potassium channels of rat skeletal muscle. Journal of Physiology, 490(3), 817-826.

Abrams CJ, Davies NW, Shelton PA and Stanfield PR. (1996). The role of a single aspartate residue in ionic selectivity and block of a murine inward rectifier K+ channel Kir2.1. Journal of Physiology, 493(3), 643-649.

Research

Research group and funding

Present group member(s): Oluwamodupe Ayeni (PhD student, with Nina Storey as second supervisor)

Current funding: British Heart Foundation

Interests

My main research focuses on two areas:

  • The physiology and biophysics of K+ channels and in particular on their regulation by haem-dependent processes. This work involves structure/function studies of haem interaction with K+ channels and an investigation of haem-dependent regulation in arterial smooth muscle and cardiac ventricular muscle.
  • The regulation of cardiac Ca2+ currents by nitric oxide. This involves examining the different signalling pathways whereby NO can modulate cardiac Ca2+ current. These experiments use the perforated single-electrode voltage-clamp technique and this will be extended to include single Ca2+ channel recordings.

Both of these projects involve detailed analysis of electrophysiological data which are obtained using single-channel, whole-cell patch-clamp and single-electrode voltage-clamp recording. I also develop analysis software and am interested in modelling electrophysiological data.

Techniques

  • Whole-cell recording of K+ currents from native cells and mammalian cell-lines
  • Single channel recording of K+ channels
  • Voltage-clamp recording of cardiac Ca2+ currents
  • Development of analysis software for electrophysiological data
  • Kinetic modelling of electrophysiological data

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Contact Details

Department of Molecular and Cell Biology
Henry Wellcome Building
Lancaster Road
Leicester
LE1 7RH (Postal)

LE1 7HB (Sat Nav/Online maps)

T:  +44(0)116 229 7038
F:  +44(0)116 229 7123
MolCellBiol@le.ac.uk

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Redfearn Lecture 2017

To Be Confirmed