Nina Storey

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Tel: +44 (0)116 229 7145

 

Personal details

Biochemistry (Hons), PhD

  • Research Associate, Department of Cell Physiology and Pharmacology, University of Leicester with Professor Nick Standen
  • Lecturer, Department of Molecular and Cell Biology, University of Leicester. 2007-Present
  • I have a PhD in Molecular Pathology, University College London with Professor Stuart Bevan.

Publications

Reecent publications

  • A heme-binding domain controls regulation of ATP-dependent potassium channels. Burton MJ, Kapetanaki SM, Chernova T, Jamieson AG, Dorlet P, Santolini J, Moody PC, Mitcheson JS, Davies NW, Schmid R, Raven EL, Storey NM. Proc Natl Acad Sci U S A. 2016 Apr 5;113(14):3785-90.
  • Monitoring Changes in the Redox State of Myoglobin in Cardiomyocytes by Raman Spectroscopy Enables the Protective Effect of NO Donors to Be Evaluated. Almohammedi A, Kapetanaki SM, Wood BR, Raven EL, Hudson AJ., Storey NM, Anal Chem. 2015 Oct 20;87(20):10605-12.
  • Spectroscopic analysis of myoglobin and cytochrome c dynamics in isolated cardiomyocytes during hypoxia and reoxygenation. Almohammedi A, Kapetanaki SM, Wood BR, Raven EL, Storey NM, Hudson AJ. J R Soc Interface. 2015 Apr 6;12(105). pii: 20141339.
  • SDF-1α and LPA modulate microglia potassium channels through rho gtpases to regulate cell morphology. Muessel MJ, Harry GJ, Armstrong DL, Storey NM.  Glia. 2013
  • Mitochondrial ROS production and subsequent ERK phosphorylation are necessary for temperature preconditioning of isolated ventricular myocytes. Bhagatte Y, Lodwick D, Storey N.  Cell Death Dis. 2012
  • Evidence that Ca2+ within the microdomain of the L-type voltage gated Ca2+ channel activates ERK in MIN6 cells in response to glucagon-like peptide-1. Selway J, Rigatti R, Storey N, Lu J, Willars GB, Herbert TP.  PLoS One. 2012
  • Kir6.2 limits calcium overload and mitochondrial oscillations of ventricular myocytes in response to metabolic stress. Storey NM, Stratton RC, Rainbow RD, Standen NB, Lodwick D.  Am J Physiol Heart Circ Physiol. 2013 Sep 6
  • Storey NM, Gentile G, Ullah H, Gentile S, Russo A, Muessel MJ, Erxleben C and Armstrong DL. (2006). Rapid signaling at the plasma membrane by a nuclear receptor for thyroid hormone. Proceedings of the National Academy of Sciences of the United States of America. 103: 5197–5201.
  • Storey NM, Gomez-Angelats M, Armstrong DL and Cidlowski J. (2003). Stimulation of Kv1.3 potassium channels by death receptors during Apotosis in Jurkat T lymphocytes. Journal of Biological Chemistry 278: 33319-33326.
  • Storey NM, O’Bryan JP and Armstrong DL. (2002). Rac and Rho mediate opposing hormonal regulation of ether-a-go-go-related potassium channel. Current Biology 12 :27-33.
  • Storey NM, Latchman DS and Bevan S. (2002) Selective internalization of sodium channels in rat dorsal root ganglion neurons infected with Herpes simplex virus-1. Journal of Cell Biology 158: 1251-1262.

Research

1994 Biochemistry (Hons), University of Edinburgh
1999 PhD Molecular Pathology, University College London
1999-2004 Visiting Fellow, membrane signalling group, National Institute of Environmental Health Sciences, National Institute of Health, USA
2005-2007 Research Associate, Department of Cell Physiology and Pharmacology, University of Leicester
2007 - present Lecturer, Department of Molecular and Cell Biology, University of Leicester
  • Cardiac ion channel regulation by intracellular signaling pathways.
  • Molecular mechanisms of cardiac protection, focusing on KATP channels.
  • Mitochondrial permeability transition pore openings and their role in cardiac disease.

Interests

Ion channel modulation underlies many physiological processes. We study the fundamental properties of heart cells and ion channel modulation by intracellular signaling pathways that regulate cardiac myocyte function.

Nina Storey Research Page Image 1

 

 

 

Fig1.  Single cardiac myocyte

 

 

 

 

Major areas of research

  • To investigate cardiac voltage-gated ion channel regulation by hormone signalling, including G protein signaling, rapid effects of steroid hormones, calcium and phosphorylation and heme.
  • To understand the molecular mechanisms of cardiac protection focusing on the role and regulation of KATP ion channels in cardiac muscle.
  • To understand the molecular processes of reperfusion injury, focusing on the central role of the mitochondria for reactive oxygen species production and mitochondrial permeability transition pore opening.

Techniques

We take an integrated approach and the methods that we currently use include the following:

  • Electrophysiology to record ion channel activity by recording action potentials or whole-cell currents and single channel currents

Fig2. Single KATP channel currents

Fig2.  Single KATP channel currents


  • Single cell imaging to detect fluorescent indicators of intracellular calcium, reactive oxygen species, mitochondrial membrane potential, and other factors or GFP tagged recombinant proteins
  • Molecular biology approaches to investigate the role and regulation of ion channels taking advantage of many types of constructs for up/down regulation of ion channel subunits and for structure function analysis
  • Measurement of single cardiac myocyte contraction

Current research group members

Modupe Ayeni

Current funding

British Heart Foundation

BBSRC

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Contact Details

Department of Molecular and Cell Biology
Henry Wellcome Building
Lancaster Road
Leicester
LE1 7RH (Postal)

LE1 7HB (Sat Nav/Online maps)

T:  +44(0)116 229 7038
F:  +44(0)116 229 7123
MolCellBiol@le.ac.uk

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Redfearn Lecture 2017

To Be Confirmed