Nina Storey

Personal Details

Dr. Nina StoreyAssociate Professor in Molecular and Cell Biology
Nina Storey DepartmentMolecular and Cell Biology
Telephone: 0116 229 7145 
Emailns140@le.ac.uk
Address: University of Leicester, Lancaster Rd, LE1 7HB
Web Linkshttps://www2.le.ac.uk/departments/molcellbiol

Biography

I am a lecturer in Molecular and Cell Biology. I read Biochemistry at Edinburgh, specializing in neuroscience, before moving into the field of molecular pathology, gaining a PhD from University College London. All of my subsequent work over the years has combined cell physiology with ion channel regulation. My postdoctoral research in potassium channel regulation in pituitary neuroendocrine cells at National Institutes of Health USA on a Visiting Fellowship resulted in a number of high impact research articles. As well as leading a research team involved in understanding cardiac ion channel regulation by intracellular signaling pathways, focusing on KATP channels and exploring the molecular mechanisms of cardiac protection. I also lead research on the role of the mitochondrial permeability transition pore openings and their role in cardiac disease.

Qualifications

  • Biochemistry (Hons), University of Edinburgh
  • PhD Molecular Pathology, University College London
  • Visiting Fellowship, National Institutes of Health, USA
  • Research Associate, University of Leicester
  • Lecturer, University of Leicester

Teaching

I teach physiology, pharmacology and pathology to biological sciences undergraduates. I train master students and PhD students in cellular pathophysiology. I am postgraduate tutor and a senior fellow of the higher education academy.

Publications

  1. Kapetenaki SM, Burton MJ, Basran J, Uragami C, Moody PC, Mitcheson JS, Schmid R, Davies NW, Dorlet P, Vos M, Raven EL, and Storey NM. A mechanism for CO regulation of ion channels. Nat Communication 2018 9, 907.
  2. Storey NM, Lambert DG Mitochondrial pharmacology turns its sights on the Ca(2+) uniporter. Cell Death Discov. 2017 3: 17064
  3. Burton MJ, Kapetanaki SM, Chernova T, Jamieson AG, Dorlet P, Santolini J, Moody PC, Mitcheson JS, Davies NW, Schmid R, Raven EL, Storey NM. A heme-binding domain controls regulation of ATP-dependent potassium channels. Proc Natl Acad Sci U S A. 2016 Apr 5;113(14):3785-90.
  4. Almohammedi A, Kapetanaki SM, Wood BR, Raven EL, Hudson AJ., Storey NM, Monitoring Changes in the Redox State of Myoglobin in Cardiomyocytes by Raman Spectroscopy Enables the Protective Effect of NO Donors to Be Evaluated. Anal Chem. 2015 Oct 20;87(20):10605-12.
  5. Almohammedi A, Kapetanaki SM, Wood BR, Raven EL, Storey NM, Hudson AJ. Spectroscopic analysis of myoglobin and cytochrome c dynamics in isolated cardiomyocytes during hypoxia and reoxygenation. J R Soc Interface. 2015 Apr 6;12(105). pii: 20141339.
  6. Storey NM, Stratton RC, Rainbow RD, Standen NB, Lodwick D. Kir6.2 limits Ca2+ overload and mitochondrial oscillations of ventricular myocytes in response to metabolic stress. Am J Physiol Heart Circ Physiol. 2013 Nov 15;305(10):H1508-18.
  7. Muessel MJ, Harry GJ, Armstrong DL, Storey NM. SDF-1α and LPA modulate microglia potassium channels through Rho GTPases to regulate cell morphology. Glia. 2013 Oct;61(10):1620-8.
  8. Bhagatte Y, Lodwick D, Storey N. Mitochondrial ROS production and subsequent ERK phosphorylation are necessary for temperature preconditioning of isolated ventricular myocytes. Cell Death Dis. 2012 Jul 5;3:e345.
  9. Selway J, Rigatti R, Storey N, Lu J, Willars GB, Herbert TP. Evidence that Ca2+ within the microdomain of the L-type voltage gated Ca2+ channel activates ERK in MIN6 cells in response to glucagon-like peptide-1. PLoS One. 2012;7(3):e33004.
  10. Storey, N.M., Gentile, G., Ullah, H., Gentile, S., Russo, A., Muessel, M.J., Erxleben, C. and Armstrong, D.L. (2006). Rapid signaling at the plasma membrane by a nuclear receptor for thyroid hormone. Proceedings of the National Academy of Sciences of the United States of America. 103: 5197–5201.
  11. Storey, N.M., Gomez-Angelats, M., Armstrong, D.L. and Cidlowski, J. (2003). Stimulation of Kv1.3 potassium channels by death receptors during Apotosis in Jurkat T lymphocytes. Journal of Biological Chemistry 278: 33319-33326.
  12. Storey, N.M., O’Bryan, J.P. & Armstrong, D.L. (2002). Rac and Rho mediate opposing hormonal regulation of ether-a-go-go-related potassium channel. Current Biology 12 :27-33.
  13. Storey N.M., Latchman D.S., and Bevan S. (2002) Selective internalization of sodium channels in rat dorsal root ganglion neurons infected with Herpes simplex virus-1. Journal of Cell Biology 158: 1251-1262.

Research

Ion channel modulation underlies many physiological processes. We study the fundamental properties of heart cells and ion channel modulation by intracellular signaling pathways that regulate cardiac myocyte function.

Major Areas of Research

  • To investigate cardiac ion channel regulation by hormone signaling, including G protein signaling and rapid effects of steroid hormones.
  • To explore signaling pathways including calcium and phosphorylation events and novel signaling pathways such as regulatory free cellular heme.
  • To understand the molecular mechanisms of cardiac protection focusing on the role and regulation of KATP ion channels in cardiac muscle.
  • To define the molecular processes of reperfusion injury, focusing on the central role of the mitochondria for reactive oxygen species production and mitochondrial permeability transition pore opening.

Techniques

We take an integrated approach and the methods that we currently use include the following:

  • Electrophysiology to record ion channel activity by recording action potentials or whole-cell currents and single channel currents
  • Single KATP channel currents
    Single KATP channel currents
  • Single cell imaging to detect fluorescent indicators of intracellular calcium, reactive oxygen species, mitochondrial membrane potential, and other factors or GFP tagged recombinant proteins
  • Molecular biology approaches to investigate the role and regulation of ion channels for structure function analysis
  • Measurement of single cardiac myocyte contraction

Supervision

I am postgraduate tutor and have supervised many PhD students to completion.

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Contact Details

Department of Molecular and Cell Biology

T: +44(0)116 229 7038
E: MolCellBiol@le.ac.uk

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