Podcast: Precision therapies for leukaemia.


  1. Carrera S, Senra J, Acosta MI, Althubiti M, Hammond EM, de Verdier PJ, Macip S. The role of the HIF-1α transcription factor in increased cell division at physiological oxygen tensions.PLoS One. 2014 May 16;9(5):e97938.

  2. Samuel J, Macip S, Dyer MJ.Efficacy of vemurafenib in hairy-cell leukemia. N Engl J Med. 2014 Jan 16;370(3):286-8. doi: 10.1056/NEJMc1310849.

  3. Carrera S, Cuadrado-Castano S, Samuel J, Jones GD, Villar E, Lee SW, Macip S. Stra6, a retinoic acid-responsive gene, participates in p53-induced apoptosis after DNA damage. Cell Death Differ. 2013 Jul;20(7):910-9. doi: 10.1038/cdd.2013.14.
  4. Dyer MJS, Vogler M, Samuel J, Jayne S, Wagner S, Pritchard C and Macip S. Precision medicines for B-cell leukaemias and lymphomas; progress and potential pitfalls. BJH, 2013 Mar;160(6):725-33. doi: 10.1111/bjh.12219.
  5. Masgras I, Carrera S, de Verdier PJ, Brennan P, Majid A, Makhtar W, Tulchinsky E, Jones GD, Roninson IB, Macip S. Reactive oxygen species and mitochondrial sensitivity to oxidative stress determine induction of cancer cell death by p21. J Biol Chem. 2012 Mar 23;287(13):9845-54.
  6. Carrera S, de Verdier PJ, Khan Z, Zhao B, Mahale A, Bowman KJ, Zainol M, Jones GD, Lee SW, Aaronson SA, Macip S. Protection of cells in physiological oxygen tensions against DNA damage-induced apoptosis. J Biol Chem. 2010 Apr 30;285(18):13658-65.
  7. Muñoz-Fontela C, Macip S, Martínez-Sobrido L, Brown L, Ashour J, García-Sastre A, Lee SW, Aaronson SA. Transcriptional role of p53 in interferon-mediated antiviral immunity. J Exp Med. 2008 Aug 4;205(8):1929-38.
  8. Tan MC, Battini L, Tuyama AC, Macip S, Melendi GA, Horga, MA. Characterization of human metapneumovirus infection of myeloid dendritic cells. Virology. 2007 Jan 5;357(1):1-9.
  9. Battini L, Fedorova E, Macip S, Li X, Wilson PD, Gusella GL. Stable knockdown of polycystin-1 confers integrin-alpha2beta1-mediated anoikis resistance. J Am Soc Nephrol. 2006 Nov;17(11):3049-58.
  10. Macip S, Kosoy A, Lee SW, O'Connell MJ, Aaronson SA. Role of a Chk1-dependent G2 checkpoint in protecting p53-null cancer cells from oxidative stress. Oncogene, 2006 (25): 6037-6047.
  11. Horga MA, Macip S, Tuyama AC, Tan MC, Gusell GL. Human parainfluenza virus 3 neuraminidase activity contributes to dendritic cell maturation. Viral Immunol. 2005;18(3):523-33.
  12. Ongusaha, PP, Kwak JC, Zwible AJ, Macip S, Higashiyama S, Taniguchi N, Fang L, Lee SW. HB-EGF is a potent inducer of tumor growth and angiogenesis. Cancer Res. 2004 Aug 1;64(15):5283-90.
  13. Ohtsuka T, Ryu H, Minamishima YA, Macip S, Sagara J, Aaronson SA, Lee SW. ASC functions as an adaptor for Bax and regulates a p53-Bax mitochondrial pathway of apoptosis. Nat Cell Biol. 2004 Feb;6(2):121-8. Epub 2004 Jan 18.
  14. Macip S, Igarashi M, Berggren P, Lee SW, Aaronson SA. Influence of induced ROS levels in determining p53-mediated growth arrest or apoptosis. Mol Cell Biol, 23(23):8576-85, 2003
  15. Macip S, Igarashi M, Fang L, Chen A, Pan ZQ, Lee SW, Aaronson SA. Inhibition of p21-mediated ROS accumulation can rescue p21-induced senescence. EMBO Journal, 21(9):2180-88, 2002

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Redfearn Lecture 2017

To Be Confirmed