Publications in international journals

Please note that the corresponding authors for papers are denoted by *

  1. Lightbody KL, Ilghari D, Waters LC, Carey G, Bailey MA, Williamson RA, Renshaw PS, Carr MD.* (2008) Molecular features governing the stability and specificity of functional complex formation by Mycobacterium tuberculosis CFP-10/ESAT-6 family proteins. J. Biol. Chem. in press, advance online publication 21 April 2008, doi/10.1074/jbc.M800123200.
  2. Veverka V, Crabbe T, Bird I, Lennie G, Muskett FW, Taylor RJ, Carr MD.* (2008) Structural characterization of the interaction of mTOR with phosphatidic acid and a novel class of inhibitor: compelling evidence for a central role of the FRB domain in small molecule-mediated regulation of mTOR. Oncogene 27, 585-595.
  3. Waters LC, Veverka V, Böhm M, Schmedt T, Choong PT, Muskett FW, Klempnauer K-H, Carr MD.* (2007) Structure of the C-terminal MA-3 domain of the tumour suppressor protein Pdcd4 and characterisation of its interaction with eIF4A. Oncogene 26, 4941-4950.
  4. Waters LC, Yue B, Veverka V, Renshaw P, Bramham J, Matsuda S, Frenkiel T, Kelly G, Muskett FW, Carr MD.*, Heery DM. (2006) Structural diversity in p160/CREB-binding protein coactivator complexes J.Biol. Chem 281, 14787-14795
  5. Waters LC, Böhm M, Veverka V, Muskett FW, Frenkiel TA, Kelly GP, Prescott A, Dosanjh NS, Klempnauer K-H, Carr MD.* (2006) NMR assignment and secondary structure determination of the C-terminal MA-3 domain of the tumour suppressor protein Pdcd4. J. Biomol. NMR 36, S5, 18.
  6. Veverka V, Gregor L, Crabbe T, Bird I, Taylor RJ, Carr MD.* (2006) Letter to the Editor: NMR assignment of the mTOR domain responsible for rapamycin binding. J. Biomol. NMR 36, S5, 3.
  7. Renshaw PS, Lightbody KL, Veverka V, Muskett FW, Kelly G, Frenkiel TA, Gordon SV, Hewinson RG, Burke B, Norman J, Williamson RA, Carr MD.* (2005) Structure and function of the complex formed by the tuberculosis virulence factors CFP-10 and ESAT-6. EMBO J. 24, 2491-2498.
  8. Marei A, Ghaemmaghami A, Renshaw P, Wiselka M, Barer M, Carr MD, Ziegler-Heitbrock L.* (2005) Superior T cell activation by ESAT-6 as compared with the ESAT-6·CFP-10 complex. Int. Immunol. 17, 1439-1446.
  9. Lightbody KL, Renshaw PS, Collins ML, Wright RL, Hunt DM, Gordon SV, Hewinson RG, Buxton RS, Williamson RA, Carr MD.* (2004) Characterisation of complex formation between members of the Mycobacterium tuberculosis complex CFP-10/ESAT-6 protein family; towards an understanding of the rules governing complex formation and thereby functional flexibility. FEMS Microbiol. Lett. 238, 255-262.
  10. Renshaw PS, Veverka V, Kelly G, Frenkiel TA, Williamson RA, Gordon SV, Hewinson RG, Carr MD.* (2004) Letter to the Editor: Sequence-specific assignment and secondary structure determination of the 195-residue complex formed by the Mycobacterium tuberculosis proteins CFP-10 and ESAT-6: Towards an understanding of their role in tuberculosis pathogenesis. J. Biomol. NMR 30, 225-226.
  11. Carr MD*, Bloemink MJ, Dentten E, Whelan AO, Gordon SV, Kelly G, Frenkiel TA, Hewinson RG, Williamson RA. (2003) Solution structure of the Mycobacterium tuberculosis complex protein MPB70: from tuberculosis pathogenesis to inherited human corneal disease. J. Biol. Chem. 278, 43736-43743.
  12. Jones G, Howard M, McIntosh P, Williamson RA, Carr MD.* (2003) Letter to the Editor: Sequence-specific assignment of the B-Myb DNA-binding domain (B-MybR2R3) bound to a 16 base-pair DNA target site corresponding to a regulatory site from the tom-1 gene.  J. Biomol. NMR 26, 375-376.
  13. Renshaw PS, Panagiotidou P, Whelan A, Gordon SV, Hewinson RG, Williamson RA, Carr MD.* (2002) Conclusive evidence that the major T-cell antigens of the M. tuberculosis complex  ESAT-6 and CFP-10 form a tight, 1:1 complex and characterisation of the structural properties of ESAT-6, CFP-10 and the ESAT-6-CFP-10 complex: implications for pathogenesis and virulence. J. Biol. Chem. 277, 21598-21603.
  14. Williamson RA*, Hutton M, Vogt G, Rapti M, Knauper V, Carr MD, Murphy G. (2001) Tyrosine 36 plays a critical role in the interaction of the AB loop of TIMP-2 with matrix metalloproteinase-14. J. Biol. Chem. 276, 32966-32970.
  15. Lemercinier X, Muskett FW, Cheeseman B, McIntosh PB, Thim L, Carr MD.* (2001) High resolution solution structure of human intestinal trefoil factor and functional insights from detailed structural comparisons with the other members of the trefoil family of cell motility factors. Biochemistry 40, 9552-9559.
  16. Bloemink MJ, Kemmink J, Dentten E, Muskett FW, Whelan A, Sheikh A, Hewinson G, Williamson RA*, Carr MD.*(2001) Sequence-specific assignment and determination of the secondary structure of the 163 residue M. tuberculosis and M. bovis antigenic protein mpb70. J. Biomol. NMR 20, 185-186.
  17. Williamson RA*, Muskett FW, Howard MJ, Freedman RB, Carr MD.* (1999) The effect of matrix metalloproteinase complex formation on the conformational mobility of tissue inhibitor of metalloproteinases-2 (TIMP-2). J. Biol. Chem. 274, 37226-37232.
  18. Muskett FW, Frenkiel TA, Feeney J, Freedman RB, Carr MD*, Williamson RA.* (1998) High resolution structure of the N-terminal domain of tissue inhibitor of metalloproteinases-2 and characterisation of its interaction site with matrix metalloproteinase-3. J. Biol. Chem. 273, 21736-21743.
  19. McIntosh PB, Frenkiel TA, Wollborn U, McCormick JE, Klempnauer K-H, Feeney J, Carr MD.* (1998). Solution structure of the B-Myb DNA-binding domain: a possible role for conformational instability of the protein in DNA-binding and control of gene expression. Biochemistry 37, 9619-9629.
  20. Bloch C, Patel SU, Baud F, Zvelebil M, Carr MD, Sadler P, Thornton, JM.* (1998) 1H NMR structure of an antifungal g-thionin protein SIa1: similarity to scorpion toxins. Proteins: Struct. Funct. Genet. 32, 334-349.
  21. Williamson RA*, Carr MD*, Frenkiel TA, Feeney J, Freedman RB. (1997) Mapping the binding site for matrix metalloproteinase on the N-terminal domain of the tissue inhibitor of metalloproteinase-2 by NMR chemical shift perturbation. Biochemistry 36, 13882-13889.
  22. Carr MD*, Wollborn U, McIntosh PB, Frenkiel TA, McCormick JE, Bauer CJ, Klempnauer K-H, Feeney J. (1996) Structure of the B-Myb DNA-binding domain in solution and evidence for multiple conformations in the region of repeat-2 involved in DNA-binding: implications for sequence-specific DNA-binding by Myb proteins. Eur. J. Biochem. 235, 721-735.
  23. Williamson RA*, Natalia D, Gee CK, Murphy G, Carr MD, Freedman RB. (1996) Chemically and conformationally authentic active domain of human tissue inhibitor of metalloproteinases-2 refolded from bacterial inclusion bodies. Eur. J. Biochem. 241, 476-483.
  24. Polshakov VI, Frenkiel TA, Westley B, Chadwick M, May F, Carr MD, Feeney J.* (1995) NMR-based structural studies of the pNR-2/pS2 single domain trefoil peptide. Similarities to porcine spasmolytic peptide (pSP) and evidence for a monomeric structure. Eur. J. Biochem. 233, 847-855.
  25. Williamson RA, Martorell G, Carr MD*, Murphy G, Docherty AJP, Freedman RB, Feeney J. (1994). Solution structure of the active domain of tissue inhibitor of metalloproteinases-2. A new member of the OB fold protein family. Biochemistry 33, 11745-11759.
  26. Carr MD*, Bauer CJ, Gradwell MJ, Feeney J. (1994). Solution structure of a trefoil-motif-containing  cell growth factor, porcine spasmolytic protein. Proc. Natl. Acad. Sci. U.S.A. 91, 2206-2210.
  27. De A, Brown DG, Gorman MA, Carr MD, Sanderson MR, Freemont P.S.* (1994). Crystal structure of a disulfide-linked trefoil motif found in a large family of putative growth factors. Proc. Natl. Acad. Sci. U.S.A. 91, 1084-1088.
  28. Soteriou A, Carr MD, Frenkiel TA, McCormick JE, Bauer CJ, Sali D, Birdsall B, Feeney J.* (1993). 3D 13C/1H NMR-based assignments for side-chain resonances of Lactobacillus casei dihydrofolate reductase. Evidence for similarities between the solution and crystal structures of the enzyme. J. Biomol. NMR 3, 535-546.
  29. Ostler G, Soteriou A, Moody CM, Khan JA, Birdsall B, Carr MD, Young D, Feeney J.*  (1993). Stereospecific assignments of the leucine methyl resonances in the 1H nuclear magnetic resonance spectrum of L.casei dihydrofolate reductase. FEBS Lett. 318, 177-180.
  30. Soteriou A, Carr MD, Frenkiel TA, Bauer CJ, McCormick JE, Birdsall B, Feeney J.* (1993). Essentially complete 13C, 15N and 1H resonance assignments for the methotrexate complex of Lactobacillus casei dihydrofolate reductase, based on isotopic labelling of the protein with 2H, 13C and 15N and multidimensional NMR spectroscopy. J. Cell. Biochem. 17, 285.
  31. Carr MD.* (1992). 1H NMR-based determination of the secondary structure of porcine pancreatic spasmolytic polypeptide: one of a new family of trefoil motif containing cell growth factors. Biochemistry 31, 1998-2004.
  32. Carr MD*, Mott RF. (1991). The transcriptional control proteins c-Myb and v-Myb contain a basic region DNA binding motif. FEBS Lett. 282, 293-294.
  33. Carr MD, Birdsall B, Frenkiel TA, Bauer CJ, Jimenez-Barbero J, Polshakov VI, McCormick JE, Roberts GCK, Feeney J.* (1991). Dihydrofolate reductase: sequential resonance assignments using 2D and 3D NMR and secondary structure determination in solution. Biochemistry 30, 6330-6341.
  34. Feeney J*, Bauer CJ, Frenkiel TA, Birdsall B, Carr MD, Roberts GCK, Arnold JRP. (1991). Deceptively simple exchange effects in homonuclear Hartmann-Hahn (HOHAHA) spectra of protein-ligand complexes. J. Magn. Reson. 91, 607-613.
  35. Frenkiel TA*, Bauer CJ, Carr MD, Birdsall B, Feeney J. (1990). HMQC-NOESY-HMQC, a three dimensional NMR experiment which allows detection of nuclear Overhauser effects between protons with overlapping signals. J. Magn. Reson. 90, 420-425.
  36. Feeney J*, Birdsall B, Ostler G, Carr MD, Kairi M. (1990). A novel method of preparing totally a-deuterated amino acids for selective incorporation into proteins: application to the assignment of 1H resonances of valine residues in dihydrofolate reductase. FEBS Lett. 272, 197-199.
  37. Birdsall B, Tendler SJB, Arnold JRP, Feeney J*, Griffin RJ, Carr MD, Thomas JA, Roberts GCK, Stevens MFG. (1990). NMR studies of multiple conformations in complexes of L.casei dihydrofolate reductase with analogues of pyrimethamine. Biochemistry 29, 9660-9667.
  38. Birdsall B, Arnold JRP, Barbero JJ, Frenkiel TA, Bauer CJ, Tendler SJB, Carr MD, Thomas JA, Roberts GCK, Feeney J.* (1990). The 1H NMR assignments of the aromatic resonances in complexes of L.casei dihydrofolate reductase and the origins of their chemical shifts. Eur. J. Biochem. 191, 659-668.
  39. Carr MD, Pastore A, Gausepohl H, Frank R, Rösch P* (1990). NMR and molecular dynamics studies of the mKr2 zinc finger. Eur. J. Biochem. 188, 455-461.
  40. Carr MD, Mulvey D, Willis A, Ferguson SJ, Campbell ID* (1990). Nucleotide binding to active and 4-chloro-7-nitrobenzofurazan inhibited forms of chloroplast F1 ATPase: an NMR study. Biochem. Biophys. Acta 1015, 79-86.

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