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Publications for last 10 years only 

2013  2012  2011  2010  2009  2003-2008

Editorials, Reviews & Chapters 


Abu-Rish EY, Amrani Y, Browning M. Toll-like receptor 9 activation induces expression of membrane-bound B-cell activating factor (BAFF) on human B cells and leads to increased profileration in response to both soluble and membrane-bound BAFF. Rheumatology (Oxford) 2013;Feb 21 [epub ahead of print]


Hartman WR, Smelter DF, Sathish V, Karass M, Kim S, Aravamudan B, Thompson MA, Amrani Y, Pandya HC, Martin RJ, Prakash YS, Pabelick CM. Oxygen dose responsiveness of human fetal airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 2012;303(8):L711-9

Bouazza B, Krytska K, Debba-Pavard M, Amrani Y, Honkanen RE, Tran J, Tliba O. Cytokines alter glucocorticoid receptor phosphorylation in airway cells: role of phosphatases. Am J Respir Cell Mol Biol 2012;47(4):464-73

Damera G, Druey KM, Cooper PR, Krymskaya VP, Soberman RJ, Amrani Y, Hoshi T, Brightling CE, Panettieri RA Jr. An RGS4-mediated phenotypic switch of bronchial smooth muscle cells promotes fixed airway obstruction in asthma. PLoS One 2012;7(1):e28504


Brightling CE, Gupta S, Hollins F, Sutcliffe A, Amrani Y. Immunopathogenesis of severe asthma. Curr Pharm Des 2011;17(7):667-73

Amrani Y, Syed F, Huang C, Li K, Liu V, Jain D, Keslacy S, Sims MW, Baidouri H, Cooper PR, Zhao H, Siddiqui S, Brightling CE, Griswold D, Li L, Panettieri RA Jr. Expression and activation of the oxytocin receptor in airway smooth muscle cells; Regulation by TNFalpha and IL-13. Respir Res 2010;29(11):104


Cruse G, Yang W, Duffy SM, Chachi L, Leyland M, Amrani Y, Bradding P. Counterregulation of beta(2)-adrenoceptor function in human mast cells by stem cell factor. J Allergy Clin Immunol 2010;125(1):257-63

Bhandare R, Damera G, Banerjee A, Flammer JR, Keslacy S, Rogatsky I, Panettieri RA, Amrani Y, Tliba O. Glucocorticoid receptor interacting protein-1 restores glucocorticoid responsiveness in steroid-resistant airway structural cells. Am J Respir Cell Mol Biol 2010;42(1):9-15


Goncharova EA, Goncharov DA, Damera G, Tliba O, Amrani Y, Panettieri RA Jr, Krymskaya VP. Signal transducer and activator of transcription 3 is required for anbromal proliferation and survival of TSC2 deficient cells: relevance to pulmonary lymphangioleiomyomatosis. Mol Pharmacol 2009;76(4):766-77

Bailey MT, Kierstein S, Sharma S, Spaits M, Kinsey SG, Tliba O, Amrani Y, Sheridan JF, Panettieri RA, Haczku A. Social stress enhances allergen-induced airway inflammation in mice and inhibits corticosteroid responsiveness of cytokine production. J Immunol 2009;182(12):7888-96


Jain D, Keslacy S, Tliba O, Cao Y, Kierstein S, Amin K, Panettieri RA Jr, Haczku A, Amrani Y. Essential role of IFNbeta and CD38 in TNFa-induced airway smooth muscle hyper-responsiveness. Immunobiology 2008;213(6):499-509

Kierstein S, Krytska K, Sharma S, Amrani Y, Salmon M, Panettieri RA Jr, Zangrilli J, Haczku A. Ozone inhalation induces exacerbation of eosinophilic airway inflammation and hyperresponsiveness in allergen-sensitized mice. Allergy 2008;63(4):438-46

Goncharova EA, Goncharov DA, Chisolm A, Spaits MS, Lim PN, Cesarone G, Khavin I, Tliba O, Amrani Y, Panettieri RA, Krymskaya VP. Interferon augments TSC2-dependent inhibition of TSC2-null ELT3 and human LAM-derived cell proliferation. Mol Pharmacol 2008;73(3):778-88

Tliba O, Damera G, Banerjee A, Gu S, Baidouri H, Keslacy S, Amrani Y. Cytokines induce an early steroid resistance in airway smooth muscle cells: Novel role of IRF-1. Am J Respir Cell Mol Biol 2008;38(4):463-72

Tliba O, Amrani Y, Panettieri RA Jr. Is airway smooth muscle the 'missing link' modulating airway inflammation in asthma? Chest 2008;133(1):236-42

Tliba O, Amrani Y. Airway smooth muscle cell as an inflammatory cell: lesions learned from interferon signaling pathways. Proc Am Thorac Soc 2008;5(1):106-12

Brightling C, Berry M, Amrani Y. Targeting TNF-alpha: a novel therapeutic approach for asthma. J Allergy Clin Immunol 2008;121(1):5-102007

Keslacy S, Tliba O, Baidouri H, Amrani Y. Inhibition of TNFa-inducible inflammatory genes by IFNg is associated with altered NF-kB transactivation and enhanced HDAC activity. Mol Pharmacol 71:609-18

Amrani Y. TNFa and calcium signaling in airway smooth muscle cells: a never-ending story with promising therapeutic relevance. Letter to the Editor. Am J Respir Cell Mol Biol 2007;36:387-8 

Amrani Y. TNF-alpha and calcium signaling in airway smooth muscle cells: a never-ending story with promosing therapeutic relevance. Am J Respir Cell Mol Biol 2007;36(3):387-8

Keslacy S, Tliba O, Baidouri H, Amrani Y. Inhibition of tumor necrosis factor-alpha-inducible inflammatory genes by interferon-gamma is associated with altered nuclear factor-kappab transactivation and enhanced histone deacetylase activity. Mol Pharmacol 2007;71(2):609-18

Tliba O, Cidlowski J, Amrani Y. CD38 expression is insensitive to steroid action in cells treated with TNF{alpha} and IFN{gamma} by a mechanism involving the upregulation of glucocorticoid receptor {beta} isoform. Mol Pharmacol 2006;69(2):588-96

Kang BN, Tirumurugaan KG, Deshpande DA, Amrani Y, Panettieri RA, Walseth TF, Kannan MS. Transcriptional regulation of CD38 expression by TNFa in human airway smooth muscle cells: role of NF-kB and sensitivity to glucocorticoids. FASEB J 2006;20(7):1000-2

Zaidi AK, Amrani Y, Panettieri RA, Ali H. Response to C3a, mast cells, and asthma. FASEB J 2006;20(2):199

Kinniry P, Amrani Y, Solomides CC, Arguiri E, Sun J, Kapoor V, Diehl AJ, Carter J, Christofidou-Solomidou M. Dietary flaxseed supplementation protects against acute lung injury and inflammation in mice: role for Nr-F2. J Nutrition 2006;136(6):1545-51

Amrani Y. Airway smooth muscle modulation and airway hyper-responsiveness in asthma: new cellular and molecular paradigms. Expert Rev Clin Immunol 2006;2(3):353-64

Thangam BE, Venkatesha RT, Zaidi AK, Kelly Jordan-Sciutto L, Goncharov DA, Krymskaya VP, Amrani Y, Panettieri RA Jr, Ali H. Airway smooth muscle cells enhance C3a-induced mast cell degranulation following cell-cell contact. FASEB J 2005;19:798-800

Syed F, Panettieri Jr RA, Tliba O, Huang C, Li K, Bracht M, Amegadzie B, Griswold D,  Lily L, Amrani Y. The effect of IL-13 and IL-13R130Q, a naturally occurring IL-13 polymorphism, on the gene expression of human airway smooth muscle cells. Respir Res 2005;6:9

Kim JH, Jain D, Tliba O, Yang B, Jester WF Jr, Panettieri RA Jr, Amrani Y, Puré E. TGF-β potentiates airway smooth muscle responsiveness to bradykinin. Am J Physiol Lung 2005;289:L511-20

Huang CD, Ammi AJ, Tliba O, Kuo H-P, Penn RB, Panettieri RA Jr, Amrani Y. G-protein-coupled receptor agonists differentially regulate basal or tumor necrosis factor-α-stimulated activation of interleukin-6 and RANTES in human airway smooth muscle cells. J Biomed Sci 2005;12(5):763-76 

Kazi S, Lotfi S, Gonchorova EA, Tliba O, Amrani Y, Krymskaya VP, Lazaar AL. Vascular endothelial growth factor-induced secretion of fibronectin is ERK-dependent. Am J Physiol Lung 2004;286:L539-45

Deshpande DA, Dogan S, Walseth TF, Miller SM, Amrani Y, Panettieri RA Jr, Kannan MS. Modulation of calcium signaling by IL-13 in human airway smooth muscle: role of CD38/cADPR pathway. Am J Respir Cell Mol Biol 2004;31:36-42

Tliba O, Panettieri RA Jr, Tliba S, Walseth TF, Amrani Y. TNFa differentially regulates the expression of pro-inflammatory genes in human airway smooth muscle cells by activation of IFNb-dependent CD38 pathway. Mol Pharmacol 2004;66:322-9 

Amrani Y, Tliba O, Choubey D, Krymskaya VP, Eszterhas A, Lazaar AL, Panettieri RA Jr. IFN-gamma inhibits human airway smooth muscle cell proliferation by modulating the E2F-1/Rb pathway. Am J Physiol 2003;284:L1063-71

Huang C-D, Tliba O, Panettieri RA Jr, Amrani Y. Bradykinin induces IL-6 production in human airway smooth muscle cells: modulation by Th2 cytokines and dexamethasone. Am J Respir Cell Mol Biol 2003;28:330-8

Chen H, Tliba O, Van Besien CR, Panettieri RA Jr, Amrani Y. TNFa modulates murine tracheal rings responsiveness to GPCR agonists and KCl. J Appl Physiol 2003;95:864-72

Rosenfeld HM, Amrani Y, Panettieri RA Jr, Spiegel S. Sphingosine-1-phosphate stimulates contraction of human airway smooth muscle cells. FASEB J 2003;17:1789-99

Tliba O, Tliba S, Da Huang C, Hoffman RK, Delong P, Panettieri RA Jr, Amrani Y. TNFα modulates airway smooth muscle function via the autocrine action of interferon beta.  J Biol Chem 2003;278:50615-23

Tliba O, Deshpande D, Chen H, Van Besien C, Kannan MS, Panettieri RA Jr, Amrani Y. IL-13 enhances agonist-evoked calcium signals and contractile responses in airway smooth muscle. Br J Pharmacol 2003;140:1159-62 


Editorials, Reviews & Chapters: Book chapters

Amrani Y, Tliba O, Panettieri RA Jr. Biology of airway smooth muscle. “Middleton’s Allergy”, edited by W Busse and S Holgate, Blackwell Science, 2008

Amrani Y. Is IKKb a feasible target for allergic asthma? Therapeutic Strategies in Asthma, Chapter 4, p49-60, 2007

Lazaar A, Amrani Y, Panettieri RA Jr. Biology of airway smooth muscle. “Middleton’s Allergy”, edited by W Busse and S Holgate, Blackwell Science, 2003

Amrani Y, Krymskaya VP, Lazaar AL, Panettieri RA Jr. Airway smooth muscle function in asthma and COPD. “Asthma and COPD: Basic mechanisms and clinical management”, edited by PJ Barnes, S Rennard, NC Thomson, Academic Press Ltd, 2001 (Book Chapter)

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Department of Respiratory Sciences
Maurice Shock Medical Sciences Building
University Road
Leicester LE1 9HN

Head of Department: Professor Mike Barer

PA: Alison Brown

General enquiries

T:+44 (0)116 252 2951