Publications

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Publications for last 10 years only 

2013  2012  2011   2010   2009   2003-2008

2013

Zhang Q, Collins J, Anastasaki A, Wallis R, Mitchell DA, Becer CR, Haddleton DM. Sequence-controlled multi-block glycopolymers to inhibit DC-SIGN-gp120 binding. Angew Chem Int Ed Engl 2013;52:4435-9.

Schelenz S, Kirchhof N, Bidula S, Wallis R, Sexton DW. Opsonizing properties of rat ficolin-A in the defence against Cryptococcus neoformans. Immunobiology 2013;218:477-83.

2012

Beveridge AJ, Wallis R, Samani NJ. A molecular dynamics study of C1r and C1s dimers: implications for the structure of the C1 complex. Proteins 2012;80:1987-97

Ali YM, Lynch NJ, Haleem KS, Fujita T, Endo Y, Hansen S, Holmskov U, Takahashi K, Stahl GL, Dudler T, Girija UV, Wallis R, Kadioglu A, Stover CM, Andrew PW, Schwaeble WJ. The lectin pathway of complement activation is a critical component of the innate immune response to pneumococcal infection. PLoS Pathog 2012;8:e1002793.

Miller A, Phillips A, Gor J, Wallis R, Perkins SJ. Near-planar solution structures of mannose-binding lectin oligomers provide insight on activation of lectin pathway of complement. J Biol Chem 2012;287:3930-45

2011

Gingras AR, Venkatraman Girija U, Keeble AH, Panchal R, Mitchell DA, Moody PCE, Wallis R. Structural basis of mannan-binding lectin recognition by its associated serine protease MASP-1: implications for complement activation. Structure 2011;19:1635-43

Schwaeble WJ, Lynch NJ, Clark JE, Marber M, Samani NJ, Ali YM, Dudler T, Parent B, Lhotta K, Wallis R, Farrar CA, Sacks S, Lee H, Zhang M, Iwaki D, Takahashi M, Fujita T, Tedford CE, Stover CM. Targeting of mannan-binding lectin associated serine protease-2 confers protection from myocardial and gastrointestinal ischemia/reperfusion injury. Proc Natl Acad Sci USA 2011;108:7523-28 

Venkatraman Girija U, Mitchell DA, Rosher S, Wallis R. Carbohydrate recognition and complement activation by rat ficolin-B. Eur J Immunol 2011;41:214-23

Ilyas R, Wallis R, Soilleux EJ, Townsend P, Zehnder D, Tan BK, Sim RB, Lehnert H, Randeva H, Mitchell D. High glucose disrupts oligosaccharide recognition function via competitive inhibition: a potential mechanism for immune dysregulation in diabetes mellitus. Immunobiology 2011;216:126-31

Sim RB, Wallis R. Surface properties: immune attack on nanoparticles. Nat Nanotechnol 2011;6:80-1

Schwaeble WJ, Ali YM, Lynch NJ, Wallis R. Complement in infections, in Complement in Health and Disease, In Press.

2010

Venkatraman Girija U, Furze C, Toth J, Schwaeble WJ, Mitchell DA, Keeble AH, Wallis R.  Engineering novel complement activity into a pulmonary surfactant protein. J Biol Chem 2010;285(14):10546-52

Wallis R, Mitchell DA, Schmid R, Schwaeble WJ, Keeble AH. Paths reunited: Initiation of the classical and lectin pathways of complement activation. Immunobiology 2010;215(1):1-11

Remzi BR, Gibson M, Geng J, Ilyas R, Mitchell DA, Wallis R, Haddleton DM. High affinity glycopolymer binding to human DC-SIGN and disruption of DC-SIGN. J Am Chem Soc 2010;132:15130-2

Thomsen T, Moeller JB, Schlosser A, Sorenson GL, Moestrup SK, Palaniyar N, Wallis R, Mollenhauer J, Holmskov U. The recognition unit of FIBCD1 organizes into a noncovalently linked tetrametric structure and uses a hydrophobic funnel (S1) for acetyl group recognition. J Biol Chem 2010;285:1229-38

2009

Phillips AE, Toth J, Dodds AW, Girija UV, Furze CM, Pala E, Sim RB, Reid KB, Schwaeble WJ, Schmid R, Keeble AH, Wallis R. Analogous interactions in initiating complexes of the classical and lectin pathways of complement. J Immunol 2009;182(12):7708-17

Farber K, Cheung G, Mitchell D, Wallis R, Weihe E, Schwaeble W, Kettenmann H. C1q, the recognition subcomponent of the classical pathway of complement, drives microglial activation. J Neurosci Res 2009;87(3):644-52

2003-2008

Wallis R, Krarup A, Venkatraman Girija U. Structure and Function of Ficolins, MBLs and MASPS, in: Molecular Aspects of Innate and Adaptive Immunity (Reid KBM and Sim RB, Eds), pp 147-156, RSC Publishing, Cambridge

Wallis R, Dodds AW, Mitchell DA, Sim RB, Reid KB, Schwaeble WJ. Molecular interactions between MASP-2, C4 and C2 and their activation fragments leading to complement activation via the lectin pathway. J Biol Chem 2007;282:7844-51

Wallis R, Lynch NJ. Biochemistry and Genetics of the Collectins. In: Collagen-Related Lectins in Innate Immunity. (Kilpatrick DC  Ed), pp 33-56, Research Signpost, Kerala, India. 2007

Wallis R. Interactions between mannose-binding lectin and MASPs during complement activation by the lectin pathway. Immunobiology 2007;212:289-99

Krarup A, Wallis R, Presanis JS, Gal P, Sim RB. Simultaneous activation of complement and coagulation by MBL-associated serine protease 2, PLoS ONE 2, 2007;e623.

Girija UV, Dodds AW, Roscher S, Reid KB, Wallis R. Localization and characterization of the mannose-binding lectin (MBL)-associated serine protease-2 binding site in rat-ficolin-a: equivalent binding sites within the collagenous domains of MBLs and ficolins. J Immunol 2007;179:455-62

Geng J, Mantovani G, Tao L, Nicolas J, Wallis R, Mitchell DA, Haddleton DM. Site-directed conjugation of "clicked" glycopolymers to form glycoprotein mimics drives mammalian lectin. Binding and induction of immunological function. J Am Chem Soc 2007;129:15156-63

Van den Steen PE, Van Aelst I, Hvidberg V, Piccard H, Fiten P, Jacobsen C, Moestrup SK, Fry S, Royle L, Wormald MR, Wallis R, Rudd PM, Dwek RA, Opdenakker G. The hemopexin and O-glycosylated domains tune gelatinase B/MMP-9 bioavailability via inhibition and binding to cargo receptors. J Biol Chem 2006;281:18626-37.

Cordes FS, Kraiczy P, Roversi P, Simon MM, Brade V, Jahraus O, Wallis R, Goodstadt L, Ponting CP, Skerka C, Zipfel PF, Wallich R, Lea SM. Structure-function mapping of BbCRASP-1, the key complement factor H and FHL-1 binding protein of Borrelia burgdorferi. Int J Med Microbiol 2006;296:177-84.

Beuron F, Dreveny I, Yuan X, Pye VE, McKeown C, Briggs LC, Cliff MJ, Kaneko Y, Wallis R, Isaacson RL, Ladbury JE, Matthews SJ, Kondo H, Zhang X, Freemont PS. Conformational changes in the AAA ATPase p97-p47 adaptor complex. EMBO J 2006;25:1967-76.

Arnold JN, Wallis R, Willis AC, Harvey DJ, Royle L, Dwek RA, Rudd PM, Sim RB. Interaction of mannan binding lectin with alpha2 macroglobulin via exposed oligomannose glycans: a conserved feature of the thiol ester protein family? J Biol Chem 2006;281:6955-63.

Wallis R, Lynch NJ, Roscher S, Reid KB, Schwaeble WJ. Decoupling of carbohydrate binding and MASP-2 autoactivation in variant mannose-binding lectins associated with immunodeficiency. J Immunol 2005;175:6846-51

Cordes FS, Roversi P, Kraiczy P, Simon MM, Brade V, Jahraus O, Wallis R, Skerka C, Zipfel PF, Wallich R, Lea SM. A novel fold for the factor H-binding protein BbCRASP-1 of Borrelia burgdorferi. Nat Struct Mol Biol 2005;12:276-7.

Yuan X, Simpson P, McKeown C, Kondo H, Uchiyama K, Wallis R, Dreveny I, Keetch C, Zhang X, Robinson C, Freemont P, Matthews S. Structure, dynamics and interactions of p47, a major adaptor of the AAA ATPase, p97. EMBO J 2004;23:1463-73.

Wallis R, Shaw JM, Uitdehaag J, Chen CB, Torgersen D, Drickamer K. Localization of the serine protease-binding sites in the collagen-like domain of mannose-binding protein: indirect effects of naturally occurring mutations on protease binding and activation. J Biol Chem 2004;279:14065-73.

Chen CB, Wallis R. Two mechanisms for mannose-binding protein modulation of the activity of its associated serine proteases. J Biol Chem 2004;279:26058-65.

Wallis R. Structural Basis for Mannose-Binding Protein Function in Innate Immunity, in Molecular Biology Intelligence Unit (Wong YC, Arsequell G, Eds), pp 34-45, Landes Bioscience, Texas, USA 2003

Feinberg H, Uitdehaag JC, Davies JM, Wallis R, Drickamer K, Weis WI. Crystal structure of the CUB1-EGF-CUB2 region of mannose-binding protein associated serine protease-2. Embo J 2003;22:2348-59.

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Contact Details

Department of Infection, Immunity and Inflammation,
Maurice Shock Medical Sciences Building,
University Road,
Leicester, LE1 9HN, UK 

General enquiries to:
Alison Brown

T:+44 (0)116 252 2951
F:+44 (0)116 252 5030

Postgraduate enquiries to: 
Susan Kapadia (PhD)

Anna Boyce (MSc)

Erasmus and Study Abroad Co-ordinator:

Professor Peter Andrew

T: +44 (0)116 252 2951

Other contact details can be found in People

Head of Department: Professor Andy Wardlaw

Deputy Head of Department: Dr Shaun Heaphy

Respiratory Team Lead: Professor David Cousins

Microbial Sciences Team Lead: TBC

Renal team Lead: Dr Jon Barratt

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