Professor Russell Wallis

Professor

Contact details

Lab: 218/219, MSB / Office: 217b, MSB

Telephone: (+44) (0)116 252 5089

Email: rw73@le.ac.uk

Research

  • I'm a biochemist interested in understanding the molecular changes that occur during initiation of the classical and lectin pathways of complement activation. These reaction cascades are directly responsible for neutralisation of pathogens and clearance of apoptotic cells. They also play key roles in stimulating and directing fundamental immunological processes, including phagocytosis, cell adhesion, modulation of immune cell function, and maintenance of immune tolerance, as well as providing important bridges between innate and adaptive immunity.
  • Specific interests include characterising the interactions between components that trigger complement activation, establishing the molecular basis of immunodeficiencies caused by mutations in key complement proteins and understanding the complex regulatory mechanisms that prevent complement from destroying host cells.

Publications

Zhang Q, Collins J, Anastasaki A, Wallis R, Mitchell DA, Becer CR, Haddleton DM. Sequence-controlled multi-block glycopolymers to inhibit DC-SIGN-gp120 binding. Angew Chem Int Ed Engl 2013;52:4435-9.

Schelenz S, Kirchhof N, Bidula S, Wallis R, Sexton DW. Opsonizing properties of rat ficolin-A in the defence against Cryptococcus neoformans. Immunobiology 2013;218:477-83.

Beveridge AJ, Wallis R, Samani NJ. A molecular dynamics study of C1r and C1s dimers: implications for the structure of the C1 complex. Proteins 2012;80:1987-97

Ali YM, Lynch NJ, Haleem KS, Fujita T, Endo Y, Hansen S, Holmskov U, Takahashi K, Stahl GL, Dudler T, Girija UV, Wallis R, Kadioglu A, Stover CM, Andrew PW, Schwaeble WJ. The lectin pathway of complement activation is a critical component of the innate immune response to pneumococcal infection. PLoS Pathog 2012;8:e1002793.

Miller A, Phillips A, Gor J, Wallis R, Perkins SJ. Near-planar solution structures of mannose-binding lectin oligomers provide insight on activation of lectin pathway of complement. J Biol Chem 2012;287:3930-45.

Gingras AR, Venkatraman Girija U, Keeble AH, Panchal R, Mitchell DA, Moody PCE, Wallis R.Structural basis of mannan-binding lectin recognition by its associated serine protease MASP-1: implications for complement activation. Structure 2011;19:1635-43

Schwaeble WJ, Lynch NJ, Clark JE, Marber M, Samani NJ, Ali YM, Dudler T, Parent B, Lhotta K, Wallis R, Farrar CA, Sacks S, Lee H, Zhang M, Iwaki D, Takahashi M, Fujita T, Tedford CE, Stover CM. Targeting of mannan-binding lectin associated serine protease-2 confers protection from myocardial and gastrointestinal ischemia/reperfusion injury. Proc Natl Acad Sci USA 2011;108:7523-28

Venkatraman Girija U, Mitchell DA, Rosher S, Wallis R. Carbohydrate recognition and complement activation by rat ficolin-B. Eur J Immunol 2011;41:214-23

Full list of publications

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Contact Details

Department of Infection, Immunity and Inflammation,
Maurice Shock Medical Sciences Building,
University Road,
Leicester, LE1 9HN, UK 

General enquiries to:
Alison Brown

T:+44 (0)116 252 2951
F:+44 (0)116 252 5030

Postgraduate enquiries to: 
Susan Kapadia (PhD)

Anna Boyce (MSc)

Erasmus and Study Abroad Co-ordinator:

Professor Peter Andrew

T: +44 (0)116 252 2951

Other contact details can be found in People

Head of Department: Professor Andy Wardlaw

Deputy Head of Department: Dr Shaun Heaphy

Respiratory Team Lead: Professor David Cousins

Microbial Sciences Team Lead: TBC

Renal team Lead: Dr Jon Barratt

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