Dr Pranab Haldar

Clinical Senior Lecturer

Contact details

Office: NIHR Leicester Biomedical Research Centre (Respiratory), Glenfield Hospital

Telephone: +44 (0)116 258 3472

Email: ph62@le.ac.uk

Personal details

I am a Clinical Senior Lecturer (University of Leicester) and Honorary Consultant Respiratory Physician (University Hospitals of Leicester NHS Trust). I co-chair the Leicester TB Research Group (LTBRG) and provide leadership to the Clinical TB Research Programme at Leicester. I have established links with the Crick Institute and continue to work closely with Prof Anne O’Garra (Senior Group Leader, Laboratory of Immunoregulation and Infection, Francis Crick Institute) on research characterising the host immune response to M.tuberculosis infection in humans. Clinically, I lead the largest rapid access TB service in the UK, providing a pathway for expedited assessment and management of new TB suspects. This clinical service is strongly integrated with an academic platform for the development and evaluation of novel clinical TB biomarkers.

Research

My primary research interest is the characterisation of important phenotypes of human M.tuberculosis infection to support development and evaluation of novel clinical biomarkers.
Specific areas of interest include:

  • Latent tuberculosis infection and progression to active TB
  • Phenotypic heterogeneity of active TB
  • Biomarker development utilising transcriptional responses of the host immune system in blood and lung to inform risk of TB progression in latent infection and therapy response in active TB
  • Precision medicine to stratify the provision and duration of treatment for latent TB and active TB
  • Evaluating pathways for implementing new biomarkers in clinical practice

Recent Publications

  • Verma R, Swift B, Handley-Hartill W, Lee J, … Haldar P. A novel high sensitivity bacteriophage-based assay identifies low level M. tuberculosis bacteraemia in immunocompetent patients with active and incipient TB. Clin Inf Dis 2019. In Press
  • Singhania A, Verma R, Graham CM,… Haldar P, O’Garra A. A modular transcriptional signature identifies phenotypic heterogeneity of human tuberculosis infection. Nat Commun. 2018 Jun 19;9(1):2308.
  • Singhania A, Wilkinson RJ, Rodrigue M, Haldar P, O'Garra A. The value of transcriptomics in advancing knowledge of the immune response and diagnosis in tuberculosis. Nat Immunol. 2018 Nov;19(11):1159-1168.
  • Abubakar I, Drobniewski F, Southern J, Sitch AJ, Jackson C, et al. Prognostic value of interferon-γ release assays and tuberculin skin test in predicting the development of active tuberculosis (UK PREDICT TB): a prospective cohort study. Lancet Infect Dis. 2018 Oct;18(10):1077-1087.
  • Panchal RK, Browne I, Monk P, Woltmann G, Haldar P. The effectiveness of primary care based risk stratification for targeted latent tuberculosis infection screening in recent immigrants to the UK: a retrospective cohort study. Thorax 2014; 69(4):354-362.
  • Haldar P, Thuraisingam H, Patel H, Pereira N, Free RC, Entwisle J et al. Single-step QuantiFERON screening of adult contacts: a prospective cohort study of tuberculosis risk. Thorax 2013; 68(3):240-246.
  • O'Connor, B. D., Woltmann, G., Patel, H., Turapov, O., Haldar, P., & Mukamolova, G. V. (2015). Can resuscitation-promoting factors be used to improve culture rates of extra-pulmonary tuberculosis?. International Journal of Tuberculosis and Lung Disease, 19(12), 1556-1557. doi:10.5588/ijtld.15.0682
  • Williams, C. M., Cheah, E. S., Malkin, J., Patel, H., Otu, J., Mlaga, K., . . ., Haldar P, Barer, M. R. (2014). Face mask sampling for the detection of Mycobacterium tuberculosis in expelled aerosols.. PLoS One, 9(8), e104921. doi:10.1371/journal.pone.0104921

Teaching

I am the Training Programme Director for Higher Specialist Training in Respiratory Medicine, Speaker at annual National TB courses and symposia hosted by the NIHR Heath Protection Research Unit (Advanced TB Course) and Qiagen (Annual TB conference at Royal College of Physicians).  Invited speaker at the Royal Society of Medicine World TB Day meeting and other National and Regional meetings

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Contact Details

Department of Infection, Immunity and Inflammation,
Maurice Shock Medical Sciences Building,
University Road,
Leicester, LE1 9HN, UK

Head of Department: Professor Mike Barer

PA: Alison Brown

General enquiries

T:+44 (0)116 252 2951