Publications

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Full list of publications

Iswahyudi, Mukamolova GV, Straatman-Iwanowska AA, Allcock N, Ajuh P. Turapov O, O’Hare HM (2019). Mycobacterial phosphatase PstP regulates global serine threonine phosphorylation and cell division.  Scientific Reports 9(1):8337

Wagner T, Andr.-Leroux G, Hindie V, Barilone N, Lisa MN, Hoos S, Raynal B, Vulliez-Le Normand B, O’Hare HM, Bellinzoni M, Alzari PM (2019). Structural insights into the functional versatility of an FHA domain protein in mycobacterial signaling.  Science Signaling 12(580).

Bhattacharyya N, Nkumama IN, Newland-Smith Z, Lin LY, Yin W, Cullen RE, Griffiths JS, Jarvis AR, Price MJ, Chong PY, Wallis R, O’Hare HM (2018). An aspartate-specific solute-binding protein regulates protein kinase G activity to control glutamate metabolism in Mycobacteria.  mBio 9(4): mBio00931-18.

Barbara Rieck, Giulia Degiacomi, Michael Zimmermann, Alessandro Cascioferro, Francesca Boldrin, Natalie R. Lazar-Adler, Andrew R. Bottrill, Fabien le Chevalier, Wafa Frigui, Marco Bellinzoni, Mar´ıa-Natalia Lisa, Pedro M. Alzari, Liem Nguyen, Roland Brosch, Uwe Sauer, Riccardo Manganelli, Helen PknG senses amino acid availability to control metabolism and virulence of Mycobacterium tuberculosis. Barbara Rieck, Giulia Degiacomi, Michael Zimmermann, Alessandro Cascioferro, Francesca Boldrin, Natalie R. Lazar-Adler, Andrew R. Bottrill, Fabien le Chevalier, Wafa Frigui, Marco Bellinzoni, Mar´ıa-Natalia Lisa, Pedro M. Alzari, Liem Nguyen, Roland Brosch, Uwe Sauer, Riccardo Manganelli, Helen M. O’Hare. PknG senses amino acid availability to control metabolism and virulence of Mycobacterium tuberculosis. . PLoS Pathogens. 2017

Garton NJ, O'Hare HM. Tuberculosis: feeding the enemy. Chem Biol. 2013;20(8):971-2.

GarA is an essential regulator of metabolism in Mycobacterium tuberculosis. Ventura M, Rieck B, Boldrin F, Degiacomi G, Bellinzoni M, Barilone N, Alzaidi F, Alzari PM, Manganelli R, O'Hare HM. Mol Microbiol. 2013;90(2):356-66.

Bortoluzzi A, Muskett FW, Waters LC, Addis PW, Rieck B, Munder T, Schleier S, Forti F, Ghisotti D, Carr MD, O’Hare HM. Mycobacterium tuberculosis RNApolymerase binding protein A (RbpA) and its interactions with sigma factors. J Biol Chem,doi:10.1074/jbc.M113.459883

Wagner T, Bellinzoni M, Wehenkel A, O'Hare HM, Alzari PM. Functional plasticity and allosteric regulation of alpha-ketoglutarate decarboxylase in central mycobacterial metabolism. Chem Biol 2011;18(8):1011-20

Nott TJ, Kelly G, Stach L, Li J, Westcott S, Patel D, Hunt DM, Howell S, Buxton RS, O'Hare HM, Smerdon SJ. An intramolecular switch regulates phosphoindependent FHA domain interactions in Mycobacterium tuberculosis. Sci Signal 2009;2(63):ra12.

O'Hare HM, Durán R, Cerveñansky C, Bellinzoni M, Wehenkel AM, Pritsch O, Obal G, Baumgartner J, Vialaret J, Johnsson K, Alzari PM. Regulation of glutamate metabolism by protein kinases in mycobacteria. Mol Microbiol 2008;70(6):1408-23

O'Hare HM, Juillerat A, Dianiskova P, Johnsson K. A split-protein sensor for studying protein-protein interaction with mycobacteria. J Microbiol Methods 2008;7392):79-84.

Sacco E, Suarez A, O'Hare HM, Carroll P, Eynard N et al. The missing piece of the type II fatty acid synthase system from Mycobacterium tuberculosis. PNAS 2007;104(37):14628-33

O'Hare HM, Johnsson K, Gautier A. Chemical probes shed light on protein function. Curr Opin Struct Biol 2007;17(4):488-94.

O'Hare HM, Choroba OW, Spencer JB. Conversion of hydroxyphenylpyruvate dioxygenases into hydroxymandelate synthases by directed evolution. FEBS Letts 2006;580(14):3445-50

O'Hare HM, Baerga-Ortiz A, Popovic B, Spencer JB, Leadlay PF. Highthroughput mutagenesis of polyketide ketoreductases reveals a model for stereochemical control. Chem Biol 2006;13(3):287-96

Baerga-Ortiz A, Popovic B, Siskos AP, O'Hare HM et al. Directed mutagenesis alters the stereochemistry of catalysis by isolated ketoreductase domains from the erythromycin polyketide synthase. Chem Biol 2006;13(3):277-85

Bali S, O'Hare HM, Weissmann KJ. Broad substrate specificity of ketoreductases derived from modular polyketide synthases. Chembiochem 2006;7(3):478-84.

O'Hare HM, Johnsson J. The laboratory in a droplet. Chem Biol 2005;12(12):1255-7

Cohen HM, Griffiths AD, Tawfik DS, Loakes D. Determinants of cofactor binding to DNA methyltransferases: insights from a systemic series of structural variants of S-adenosylhomocysteine. Org Biomol Chem 2005;3(1):152-61

Cohen HM, Tawfik DS, Griffiths AD. Altering the sequence specificity of HaeIII methyltransferase by directed evolution using in vitro compartmentalisation. Protein Eng Des Sel 2004;17(1):3-11

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Department of Respiratory Sciences
Maurice Shock Medical Sciences Building
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Leicester LE1 9HN

Head of Department: Professor Mike Barer

PA: Alison Brown

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