Dr Helen O'Hare

Lecturer

Lab: 136 
Office (MSB): 129a

Telephone: +44 (0)116 252 2947

Email: hmo7@le.ac.uk

Research

My group are investigating how bacteria sense and respond to changes in their environment. Our goal is to understand the molecular basis for sensory perception and signal transduction and how these regulate metabolism of pathogenic bacteria, model organisms and industrial organisms. Recently, we have focused on the role of protein kinases in the ability of Mycobacterium tuberculosis to cause disease.

Funded PhD student opportunity

Publications

Selected recent publications

Iswahyudi, Mukamolova GV, Straatman-Iwanowska AA, Allcock N, Ajuh P. Turapov O, O’Hare HM (2019). Mycobacterial phosphatase PstP regulates global serine threonine phosphorylation and cell division Scientific Reports 9(1):8337

Wagner T, Andr.-Leroux G, Hindie V, Barilone N, Lisa MN, Hoos S, Raynal B, Vulliez-Le Normand B, O’Hare HM, Bellinzoni M, Alzari PM (2019). Structural insights into the functional versatility of an FHA domain protein in mycobacterial signaling Science Signaling 12(580).

Bhattacharyya N, Nkumama IN, Newland-Smith Z, Lin LY, Yin W, Cullen RE, Griffiths JS, Jarvis AR, Price MJ, Chong PY, Wallis R, O’Hare HM (2018). An aspartate-specific solute-binding protein regulates protein kinase G activity to control glutamate metabolism in Mycobacteria. mBio 9(4): mBio00931-18.

Barbara Rieck, Giulia Degiacomi, Michael Zimmermann, Alessandro Cascioferro, Francesca Boldrin, Natalie R. Lazar-Adler, Andrew R. Bottrill, Fabien le Chevalier, Wafa Frigui, Marco Bellinzoni, Mar´ıa-Natalia Lisa, Pedro M. Alzari, Liem Nguyen, Roland Brosch, Uwe Sauer, Riccardo Manganelli, Helen PknG senses amino acid availability to control metabolism and virulence of Mycobacterium tuberculosis. Barbara Rieck, Giulia Degiacomi, Michael Zimmermann, Alessandro Cascioferro, Francesca Boldrin, Natalie R. Lazar-Adler, Andrew R. Bottrill, Fabien le Chevalier, Wafa Frigui, Marco Bellinzoni, Mar´ıa-Natalia Lisa, Pedro M. Alzari, Liem Nguyen, Roland Brosch, Uwe Sauer, Riccardo Manganelli, Helen M. O’Hare. PknG senses amino acid availability to control metabolism and virulence of Mycobacterium tuberculosis.  PLoS Pathogens. 2017

Garton NJ, O'Hare HM. Tuberculosis: feeding the enemy. Chem Biol. 2013;20(8):971-2.

Ventura M, Rieck B, Boldrin F, Degiacomi G, Bellinzoni M, Barilone N, Alzaidi F, Alzari PM, Manganelli R, O'Hare HM. GarA is an essential regulator of metabolism in Mycobacterium tuberculosis. Mol Microbiol. 2013;90(2):356-66.

Bortoluzzi A, Muskett FW, Waters LC, Addis PW, Rieck B, Munder T, Schleier S, Forti F, Ghisotti D, Carr MD, O’Hare HM. Mycobacterium tuberculosis RNApolymerase binding protein A (RbpA) and its interactions with sigma factors. J Biol Chem. 2013 May 17;288(20):14438-50

Wagner T, Bellinzoni M, Wehenkel A, O'Hare HM, Alzari PM. Functional plasticity and allosteric regulation of alpha-ketoglutarate decarboxylase in central mycobacterial metabolism. Chem Biol 2011;18(8):1011-20

Nott TJ, Kelly G, Stach L, Li J, Westcott S, Patel D, Hunt DM, Howell S, Buxton RS, O'Hare HM, Smerdon SJ. An intramolecular switch regulates phosphoindependent FHA domain interactions in Mycobacterium tuberculosis. Sci Signal 2009;2:ra12.

Full list of publications

Teaching

I am the director of the BSc in Medical Microbiology and BSc in Biological Sciences (microbiology)

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Contact Details

Department of Respiratory Sciences
Maurice Shock Medical Sciences Building
University Road
Leicester LE1 9HN

Head of Department: Professor Mike Barer

PA: Alison Brown

General enquiries

T:+44 (0)116 252 2951