Dr Helen O'Hare

Lecturer

Lab: 136 
Office (MSB): 129a

Telephone: +44 (0)116 252 2947

Email: hmo7@le.ac.uk

Research

My group are investigating how bacteria sense and respond to changes in their environment. Our goal is to understand the molecular basis for sensory perception and signal transduction and how these regulate metabolism of pathogenic bacteria, model organisms and industrial organisms. Recently, we have focused on the role of protein kinases in the ability of Mycobacterium tuberculosis to cause disease.

Funded PhD student opportunity

Publications

Selected recent publications

PknG senses amino acid availability to control metabolism and virulence of Mycobacterium tuberculosis. Barbara Rieck, Giulia Degiacomi, Michael Zimmermann, Alessandro Cascioferro, Francesca Boldrin, Natalie R. Lazar-Adler, Andrew R. Bottrill, Fabien le Chevalier, Wafa Frigui, Marco Bellinzoni, Mar´ıa-Natalia Lisa, Pedro M. Alzari, Liem Nguyen, Roland Brosch, Uwe Sauer, Riccardo Manganelli, Helen PknG senses amino acid availability to control metabolism and virulence of Mycobacterium tuberculosis. Barbara Rieck, Giulia Degiacomi, Michael Zimmermann, Alessandro Cascioferro, Francesca Boldrin, Natalie R. Lazar-Adler, Andrew R. Bottrill, Fabien le Chevalier, Wafa Frigui, Marco Bellinzoni, Mar´ıa-Natalia Lisa, Pedro M. Alzari, Liem Nguyen, Roland Brosch, Uwe Sauer, Riccardo Manganelli, Helen M. O’Hare. PLoS Pathogens. 2017

Tuberculosis: feeding the enemy. Garton NJ, O'Hare HM. Chem Biol. 2013;20(8):971-2.

GarA is an essential regulator of metabolism in Mycobacterium tuberculosis. Ventura M, Rieck B, Boldrin F, Degiacomi G, Bellinzoni M, Barilone N, Alzaidi F, Alzari PM, Manganelli R, O'Hare HM. Mol Microbiol. 2013;90(2):356-66.

Bortoluzzi A, Muskett FW, Waters LC, Addis PW, Rieck B, Munder T, Schleier S, Forti F, Ghisotti D, Carr MD, O’Hare HM. Mycobacterium tuberculosis RNApolymerase binding protein A (RbpA) and its interactions with sigma factors. J Biol Chem 2012, doi:10.1074/jbc.M113.459883

Wagner T, Bellinzoni M, Wehenkel A, O'Hare HM, Alzari PM. Functional plasticity and allosteric regulation of alpha-ketoglutarate decarboxylase in central mycobacterial metabolism. Chem Biol 2011;18(8):1011-20

Nott TJ, Kelly G, Stach L, Li J, Westcott S, Patel D, Hunt DM, Howell S, Buxton RS, O'Hare HM, Smerdon SJ. An intramolecular switch regulates phosphoindependent FHA domain interactions in Mycobacterium tuberculosis. Sci Signal 2009;2:ra12.

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Contact Details

Department of Infection, Immunity and Inflammation,
Maurice Shock Medical Sciences Building,
University Road,
Leicester, LE1 9HN, UK

Head of Department: Professor Mike Barer

PA: Alison Brown

General enquiries

T:+44 (0)116 252 2951