Professor Galina Mukamolova

Professor in Microbial Physiology

Office: 237, MSB

Tel - office: +44 (0)116 229 7053

Tel - laboratory: +44 (0)116 252 1518

Email: gvm4@le.ac.uk

Research

  • Molecular mechanisms of bacterial dormancy and resuscitation.
  • Role of serine-threonine kinase in growth, cell wall remodelling and dormancy
  • Antimicrobial resistance and tolerance
  • Development of models for drug validation and drug discovery

Recent publications (last 5 years)

Sulman S, Savidge BO, Alqaseer K, Das MK, Nezam Abadi N, Pearl JE, Turapov O, Mukamolova GV, Akhtar MW, Cooper AM. Balance between protection and pathogenic response to aerosol challenge with Mycobacterium tuberculosis (Mtb) in mice vaccinated with TriFu64, a Fusion Consisting of Three Mtb Antigens. Vaccines (Basel). 2021 May 18;9(5):519. doi: 10.3390/vaccines9050519.

Farzand R, Rajakumar K, Barer MR, Freestone PPE, Mukamolova GV, Oggioni MR, O'Hare HM. (2021). A virulence associated siderophore importer reduces antimicrobial susceptibility of Klebsiella pneumoniae. Front Microbiol 12:607512. doi: 10.3389/fmicb.2021.607512.

Bancroft P, Turapov O, Jagatia H, Arnvig K, Mukamolova GV, Green J. (2020). Coupling of Peptidoglycan Synthesis to Central Metabolism in Mycobacteria: Post-transcriptional Control of CwlM by Aconitase. Cell Rep. 2020 Sep 29;32(13):108209. doi: 10.1016/j.celrep.2020.108209.

Faraj A, Clewe O, Svensson RJ, Mukamolova GV, Barer MR, Simonsson USH. (2020) Difference in persistent tuberculosis bacteria between in vitro and sputum from patients: implications for translational predictions. Sci Rep. 2020 Sep 23;10(1):15537. doi: 10.1038/s41598-020-72472-y.

Commandeur S, Iakobachvili N, Sparrius M, Nur MM, Mukamolova GV, Bitter W. (2020). A zebrafish embryo model for assessment of drug efficacy on mycobacterial persisters. Antimicrobial Agents Chemother. AAC.00801-20. doi: 10.1128/AAC.00801-20.

Alqaseer K, Turapov O, Barthe P, Jagatia H, De Visch A, Roumestand C, Wegrzyn M, Bartek IL, Voskuil MI, O'Hare HM, Ajuh P, Bottrill AR, Witney AA, Cohen-Gonsaud M, Waddell SJ, Mukamolova GV. (2019) Protein kinase B controls Mycobacterium tuberculosis growth via phosphorylation of the transcriptional regulator Lsr2 at threonine 112. Mol Microbiol. 112(6):1847-1862.

Jenkins CH, Wallis R, Allcock N, Barnes KB, Richards MI, Auty JM, Galyov EE, Harding SV, Mukamolova GV. (2019) The lytic transglycosylase, LtgG, controls cell morphology and virulence in Burkholderia pseudomallei. Sci Rep 9 (1): 11060.

Loraine J, Alhumaidan O, Bottrill AR, Mistry SC, Andrew P, Mukamolova GV, Turapov O. (2019). Efficient protein digestion at elevated temperature in the presence of sodium dodecyl sulfate and calcium ions for membrane proteomics. Anal Chem. 91(15):9516-9521.

Moynihan PJ, Cadby IT, Veerapen N, Jankute M, Crosatti M, Mukamolova GV, Lovering AL, Besra GS. (2019). The hydrolase LpqI primes mycobacterial peptidoglycan recycling. Nat Commun 10(1):2647. doi: 10.1038/s41467-019-10586-2.

Iswahyudi, Mukamolova GV, Straatman-Iwanowska AA, Allcock N, Ajuh P, Turapov O, O'Hare HM. (2019) Mycobacterial phosphatase PstP regulates global serine threonine phosphorylation and cell division. Sci Rep 9(1):8337. doi: 10.1038/s41598-019-44841-9.

Turapov O, Forti F, Kadhim B, Ghisotti D, Sassine J, Straatman-Iwanowska, Bottrill AR, Moynihan P, Wallis R, Barthe P, Cohen-Gonsaud M, Ajuh P, Vollmer W, Mukamolova GV. (2018). Two faces of CwlM, an essential PknB substrate, in Mycobacterium tuberculosis. Cell Rep 25(1): 57-67. e 5.

Tarapdar A, Norris JKS, Sampson O, Mukamolova G, Hodgkinson JT. (2018). The design and synthesis of an antibacterial phenothiazine-siderophore conjugate. Beilstein J Org Chem 14: 2646-2650.

Rosser A, Richardson M, Wiselka MJ, Free R, Woltmann G, Mukamolova GV, Pareek M. (2018). A nested case-control study of predictors for tuberculosis recurrence in a large UK centre. BMC Infect Dis 18(1):94.

Rosser A, Pareek M, Turapov O, Wiselka MJ, Mukamolova GV. (2018) Differentially culturable tubercule bacilli are generated during non-pulmonary tuberculosis Infection. Am J Respir Crit Care Med. 2017 Sep 7 197(6):818-821.

Smith L, Bochkareva A, Rolfe M, Hunt D, Kahramanoglou C, Braun Y, Rodgers A, Blockley A, Coade S, Lougheed K, Hafneh NA, Glenn S, Crack J, LeBrun N, Saldanha J, Makarov V, Nobeli I, Arnvig K, Mukamolova G, Buxton R, Green J. (2017). Rv1675c is a redox-responsive regulator of DosR that contributes to Mycobacterium tuberculosis virulence. Nucleic Acid Res, 45: 6600-6612.

Rosser A, Stover C, Pareek M, Mukamolova GV. Resuscitation-promoting factors are important determinants of the pathophysiology in Mycobacterium tuberculosis infection. (2017). Crit Rev Microbiol. 2017 Feb 17:1-10.

Loraine J, Pu F, Turapov O, Mukamolova GV. (2016) Development of an in vitro assay for detection of drug induced Resuscitation-promoting factor dependent mycobacteria. Antimicrob Agents Chemother 60(10): 6227-33.

Turapov O, O’Connor B, Sarybaeva AA, Williams C, Patel H, Kadyrov AS, Sarybaev A, Woltmann G, Barer MR, Mukamolova GV. (2016). Phenotypically adapted Mycobacterium tuberculosis populations from sputum are tolerant to first line drugs. Antimicrob Agents Chemother. 60(4): 2476-83.

Published patents and their application

  • Bacterial pheromones and uses thereof (co-authors: G V Mukamolova, A S Kaprelyants, D I Young & D B Kell).
  • 1997: Priority filing (UK patent application 9711389.8)
  • 1998: PCT phase International application (PCT/GB98/01619)
  • 2000: South African Patent Number 98/4838
  • 2002: Australian Patent Number 77797/98
  • 2004: New Zealand Patent Number 501568
  • 2006: Eurasian Patent Number 200001127
  • Rpf proteins are now being validated as vaccine candidates (Aeras 407) in clinical trial phase I (AERAS Global TB Vaccine Foundation). Please see Stop TB Partnership for further information.

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