Professor Galina Mukamolova

Professor in Microbial Physiology

Office: 217c, MSB

Tel - office: +44 (0)116 229 7053

Tel - laboratory: +44 (0)116 252 1518

Email: gvm4@le.ac.uk

Research

  • Molecular mechanisms of bacterial dormancy and resuscitation.
  • Role of serine-threonine kinase in growth, cell wall remodelling and dormancy
  • Antimicrobial tolerance
  • Biomarkers of non-replicating persistence.

Recent publications

1. Rosser A, Pareek M, Turapov O, Wiselka MJ, Mukamolova GV. (2017) Differentially culturable tubercule bacilli are generated during non-pulmonary tuberculosis Infection. Am J Respir Crit Care Med. 2017 Sep 7 [Epub ahead of print].

2. Smith L, Bochkareva A, Rolfe M, Hunt D, Kahramanoglou C, Braun Y, Rodgers A, Blockley A, Coade S, Lougheed K, Hafneh NA, Glenn S, Crack J, LeBrun N, Saldanha J, Makarov V, Nobeli I, Arnvig K, Mukamolova G, Buxton R, Green J. (2017). Rv1675c is a redox-responsive regulator of DosR that contributes to Mycobacterium tuberculosis virulence. Nucleic Acid Res, 45: 6600-6612.

3. Rosser A, Stover C, Pareek M, Mukamolova GV. Resuscitation-promoting factors are important determinants of the pathophysiology in Mycobacterium tuberculosis infection. (2017). Crit Rev Microbiol. 2017 Feb 17:1-10.

4. Loraine J, Pu F, Turapov O, Mukamolova GV. (2016) Development of an in vitro assay for detection of drug induced Resuscitation-promoting factor dependent mycobacteria. Antimicrob Agents Chemother 60(10): 6227-33.

5. Turapov O, O’Connor B, Sarybaeva AA, Williams C, Patel H, Kadyrov AS, Sarybaev A, Woltmann G, Barer MR, Mukamolova GV. (2016). Phenotypically adapted Mycobacterium tuberculosis populations from sputum are tolerant to first line drugs. Antimicrob Agents Chemother. 60(4): 2476-83.

6. Turapov O, Loraine J, Jenkins CH, Barthe P, McFeely D, Forti F, Ghisotti D, Hesek D, Lee M, Bottrill AR, Vollmer W, Mobashery S, Cohen-Gonsaud M, Mukamolova GV. 2015. The external PASTA domain of the essential serine/threonine protein kinase PknB regulates mycobacterial growth. Open Biology, 5(7): 150025.

7.O’Connor B, Woltmann G, Patel H; Turapov O, Haldar P, Mukamolova GV. 2015. Can Resuscitation-promoting factors be used to improve culture rates of extrapulmonary tuberculosis? Int J Tuberc Lung Dis. 19(12): 1556-7.

8.Turapov O, Glenn S, Kana B, Makarov V, Andrew PW, Mukamolova GV. 2014. The in vivo environment accelerates generation of Resuscitation-promoting factor–dependent mycobacteria. Am J Respir Crit Care Med. 190: 1455-7

9.Turapov O, Waddell SJ, Burke B, Glenn S, Sarybaeva AA, Tudo G, Labesse G, Young D, Young M, Andrew PW, Butcher PD, Cohen-Gonsaud M, Mukamolova GV. 2014. Oleoyl coenzyme A regulates interaction of transcriptional regulator RaaS (Rv1219c) with DNA in mycobacteria. J Biol Chem. 289: 25241-9

10.Turapov O, Waddell SJ, Burke B, Glenn S, Sarybaeva AA, Tudo G, Labesse G, Young D, Young M, Andrew PW, Butcher PD, Cohen-Gonsaud M, Mukamolova GV. 2014. Antimicrobial treatment improves mycobacterial survival in non-permissive growth conditions.  Antimicrob Agents Chemother 58: 2798-806.

Published patents and their application

  • Bacterial pheromones and uses thereof (co-authors: G V Mukamolova, A S Kaprelyants, D I Young & D B Kell).
  • 1997: Priority filing (UK patent application 9711389.8)
  • 1998: PCT phase International application (PCT/GB98/01619)
  • 2000: South African Patent Number 98/4838
  • 2002: Australian Patent Number 77797/98
  • 2004: New Zealand Patent Number 501568
  • 2006: Eurasian Patent Number 200001127
  • Rpf proteins are now being validated as vaccine candidates (Aeras 407) in clinical trial phase I (AERAS Global TB Vaccine Foundation). Please see Stop TB Partnership for further information.

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Contact Details

Department of Infection, Immunity and Inflammation,
Maurice Shock Medical Sciences Building,
University Road,
Leicester, LE1 9HN, UK

Head of Department: Professor Mike Barer

PA: Alison Brown

General enquiries

T:+44 (0)116 252 2951