Dr Cordula Stover

Senior Lecturer in Immunology

Contact details

Office 229a, MSB

Telephone: +44 (0)116 252 5032

Email: cms13@le.ac.uk

Personal details

Doctor of Medicine (Dr med), PhD

Main achievements

My main achievements include establishing MASP-2, properdin, and properdin/LDLR deficient hosts. Significant contributions to the field of complement in polymicrobial sepsis and non-septic shock, ischemia and chronic arthritic inflammation, international collaborations.

Responsibilities

  • Supervisorial: teaching (immunology), progress review panel member, ethical review and animal welfare committee, genome science steering committee.
  • Exam Boards: (MSc, BSc)
  • Module convenor MSc Infection and Immunity (MB7305), CRF management committee

Memberships

Royal Society of Medicine (Regional Fellow), Society of General Microbiology, British Society of Immunology, Infectious Disease Research Network, Academia Net, British Science Association.

Patents

Co-inventor Licence Agreement (University of Leicester/Omeros Corporation USA): "Methods for treating conditions associated with MASP-2 dependent complement activation".

Publications

Selected recent publications

  • Kouser L, Abdul-Aziz M, Nayak A, Stover CM, Sim RB, Kishore U. Properdin and factor HL opposing players on the alternative complement pathway "see-saw". Front Immunol 2013;4:93
  • Ruseva MM, Vernon KA, Lesher AM, Schwaeble WJ, Ali YM, Botto M, Cook T, Song W, Stover CM, Pickering MC. Loss of properdin exacerbates C3 glomerulopathy resulting from factor H deficiency. J Am Soc Nephrol 2013;24(1):43-52
  • Dimitrova P, Ivanovska N, Belenska L, Milanova V, Schwaeble WJ, Stover CM. Abrogated RANKL expression in properdin-deficient mice is associated with better outcome from collagen-antibody-induced arthritis. Arthritis Res Ther 2012;14(4):R173
  • Ali YM, Lynch NJ, Haleem KS, Fujita T, Endo Y, Hansen S, Holmskov U, Takahashi K, Stahl GL, Dudler T, Girija UV, Wallis R, Kadioglu A, Stover CM, Andrew PW, Schwaeble WJ. The lectin pathway of complement activation is a critical component of the innate murine response to pneumococcal infection. PLoS Pathog 2012;8(7):e1002793
  • Schwaeble WJ, Lynch NJ, Clark JE, Marber M, Samani NJ, Ali YM, Dudler T, Parent B, Lhotta K, Wallis R, Farrar CA, Sacks S, Lee H, Zhang M, Iwaki D, Takahashi M, Fujita T, Tedford CE, Stover CM. Targeting of mannan-binding lectin-associated serine protease-2 confers protection from myocardial and gastrointestinal ischemia/reperfusion injury. Proc Natl Sci USA 2011;108(18):7523-8
  • Stover C. Dual role of complement in tumour growth and metastasis [Review]. Int J Mol Med 2010;25(3):307-13
  • Staley KG, Kuehni CE, Strippoli MP, McNally T, Silverman M, Stover C. Properdin in childhood and its association with wheezing and atopy. Pediatr Allergy Immunol 2010;21(4 pt 2):e787-91
  • Dimitrova P, Ivanovska N, Schwaeble C, Gyurkovska V, Stover C. The role of properdin in murine zymosan-induced arthritis. Mol Immunol 2010;47(7-8):1458-66

View a full list of publications.

Research

  • Role of properdin in tumour growth and metastasis
  • Properdin in diet induced vascular inflammation
  • Role of properdin in instructing cell phenotypes in murine infectious disease models
  • Role of properdin in septicemia and shock
  • Inflammatory component of ischemic and proteinuric kidney disease
  • Clinical collaborations

Current work

  • Medical studies University of Mainz, Germany, qualification to practice medicine, academic degree of Dr med for 2 year exptl work in autoimmune endocrinology.
  • House Officer posts Leicester Royal Infirmary
  • Research Scholar (DAAD stipend) in Dept of Microbiology and Immunology, Research Assistant posts.
  • PhD University of Leicester
  • Research Fellowship, University of Marburg, Germany
  • Honorary Lectureship, Ludwig Maximilians University Munich, Germany
  • Lectureship, Department of Infection, Immunity & Inflammation, Currently, Senior Lecturer
  • Regional Fellow, Royal Society of Medicine, Academic Editor PLOS One.

Supervision

Funded studentships

There are no studentships available at present. Please check here at a later date.

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