Dr Bin Yang

 

Honorary Reader in Nephrology

Senior Research Scientist, University Hospitals of Leicester NHS Trust

Contact details

Lab 228 / Office 233, MSB

Telephone: (+44) (0)116 2231406 or 2523017

E-mail: by5@le.ac.uk or dryangbin@hotmail.com

Qualifications

Jan 2002: Doctor of Philosophy (PhD), University of Sheffield, UK

Jul 1989:  Doctor of Medicine (MD), Nantong University, China

Jul 1986:  Bachelor of Medicine (MBChB), Nantong University, China

Research Interests 

My main research interests are the mechanism, diagnosis and intervention of acute and chronic renal injury including both native and transplanted kidneys, with focuses and expertise on cell fate, inflammation, immunity and fibrosis, detailed as the following:

  • Isolated organ perfusion system: Validated and further evaluated the effects of erythropoietin (EPO) and caspase-3 siRNA using this system.
  • Gene profiling: defined and validated potential biomarkers such as SERPINA3, SLP1 and FTCD in human transplanted renal biopsy samples using microarray analysis.
  • Specific gene therapy: Performed a series of investigations using synthetic caspase-3 siRNA in LLC-PK1 cells, isolated kidney perfusion system, and auto-transplantation porcine models.
  • Renoprotection of EPO & its derivatives: helix B surface peptide (HBSP) and cyclic HBSP (CHBP) remain tissue protection without erythropoiesis, which were assessed in a variety of acute kidney injury models, and their underlying mechanisms were disclosed.

On-going Research Projects

  • Exploring the gene profile in human renal biopsy, as well as blood and urine samples, selecting and validating potential biomarkers for diagnosis and intervention. 
  • Defining the role of properdin (an immune regulator) in renal ischemia reperfusion injury using cell culture and animal models.
  • Designing and evaluating siRNA delivery system to achieve timely and cell-specific intervention such as using HBSP targeting β common receptor (βcR)/EPOR highly expressed cells.

International collaborations

  • Visiting Professor in Urology, Zhongshan Hospital, Fudan University: obtained joint grants from Department for Business Innovation & Skills in UK, and Fudan University; co supervised PhD students; helped to establish the Sister Transplant Center, supported by the Transplantation Society; published research papers with joint names.
  • Distinguished Professor in Affiliated Hospital of Nantong University: organized numerous mutual visiting; obtained joint grants; co supervised MD students; facilitated an English Training Program in Leicester for Nantong academic staff; initiated a split-site joint PhD scheme between Leicester and Nantong universities; and helped to establish the Sister Renal Center, supported by the International Society of Nephrology.

 

Potential PhD student interest please click on the following link : http://www2.le.ac.uk/departments/iii/postgraduate/research/projects/phd-projects-available

 

Selected Recent Published Original Articles (*: corresponding author)

  1. Yang C, Hosgood SA, Patel M, Long, YQ, Zhu TY, Nicholson ML, Yang B*. Cyclic Helix B Peptide in Preservation Solution and Autologous Blood Perfusate Ameliorates Ischemia-Reperfusion Injury in Isolated Porcine Kidneys. Transplantation Direct 2015;1:1-9
  2. Yang C, Zhao T, Zhao Z, Jia Y, Li L, Zhang Y, Song M, Rong R, Xu M, Nicholson ML, Zhu T, Yang B*. Serum Stabilized Naked Caspase-3 siRNA Protects Auto-transplant Kidneys in a Porcine Model. Mol Ther 2014;22:1817-28
  3. Zhao Z, Yang C, Li L, Zhao T, Wang L, Rong R, Yang B*, Xu M, Zhu T. Increased peripheral and local soluble FGL2 in the recovery of renal ischemia reperfusion injury in a porcine kidney auto-transplantation model. J Transl Med 2014;12:53
  4. Han J, Zhang L, Chen X, Yang B*, Guo N, Fan Y. Effects of all-trans retinoic acid on signal pathway of cyclooxygenase-2 and Smad3 in transforming growth factor-β-stimulated glomerular mesangial cells. Exp Biol Med 2014;239:272-83
  5. Wu Y, Zhang J, Liu F, Yang C, Zhang Y, Liu A, Shi L, Wu Y, Zhu T, Nicholson ML, Fan Y, Yang B*. Protective effects of HBSP on ischemia reperfusion and cyclosporine A induced renal injury. Clin Dev Immunol 2013;2013:758159
  6. Yang C, Li L, Xue Y, Zhao Z, Zhao T, Jia Y, Rong R, Xu M, Nicholson ML, Zhu T, Yang B*. Innate immunity activation involved in unprotected porcine auto-transplant kidneys preserved by naked caspase-3 siRNA. J Transl Med 2013;11:210
  7. Yang C, Zhao T, Lin M, Zhao Z, Hu L, Jia Y, Xue Y, Xu M, Tang Q, Yang B*, Rong R, Zhu T. Helix B surface peptide administered after insult of ischemia reperfusion improved renal function, structure and apoptosis through beta common receptor/erythropoietin receptor and PI3K/Akt pathway in a murine model. Exp Biol Med 2013;238:111-9
  8. Yang C, Jia Y, Zhao T, Xue Y, Zhao Z, Zhang J, Wang J, Wang X, Qiu Y, Lin M, Zhu D, Qi G, Qiu Y, Tang Q, Rong R, Xu M, Ni S, Lai B, Nicholson ML, Zhu T, Yang B*. Naked caspase 3 small interfering RNA is effective in cold preservation but not in autotransplantation of porcine kidneys. J Surg Res 2013;181: 342-354
  9. Yang B*, Hosgood SA, Da Z, Harper SJ, Waller HL, Kay MD, Furness PN, Nicholson ML. Biomarkers assessing warm ischemic injury using an isolated porcine kidney hemoreperfusion model. Exp Biol Med 2012;237:1462-73
  10. Jia Y, Zhao Z, Xu M, Zhao T, Qiu Y, Ooi Y, Yang B*, Rong R, Zhu T. Prevention of renal ischemia-reperfusion injury by short hairpin RNA of endothelin A receptor in a rat model. Exp Biol Med 2012;237(8):894-902
  11. Jiang S, Tang Q, Rong R, Tang L, Xu M, Lu J, Jia Y, Ooi Y, Hou J, Guo J, Yang B*, Zhu T. Mycophenolate mofetil inhibits macrophage infiltration and kidney fibrosis in long-term ischemia-reperfusion injury. Eur J Pharmacol  2012;688:56-61
  12. Hu L, Yang C, Zhao T, Xu M, Tang Q, Yang B*, Rong R, Zhu T. Erythropoietin ameliorates renal ischemia and reperfusion injury via inhibiting tubulointerstitial inflammation. J Surg Res 2012;176:260-6
  13. Haylor JL, Harris KP, Nicholson ML, Waller HL, Huang Q, Yang B*. Atorvastatin improving renal ischemia reperfusion injury via direct inhibition of active caspase-3 in rats. Exp Biol Med 2011;236:755-63
  14. Yang B*, Hosgood SA, Bagul A, Waller HL, Nicholson ML. Erythropoietin regulates apoptosis, inflammation and tissue remodelling via caspase-3 and IL-1β in isolated hemoperfused kidneys. Eur J Pharmacol 2011;660:420-30
  15. Yang B*, Elias JE, Bloxham M, Nicholson ML. Synthetic small interfering RNA down-regulates caspase-3 and affects apoptosis, IL-1 β, and viability of porcine proximal tubular cells. J Cell Biochem 2011;112:1337-47
  16. Yang B*, Hosgood SA, Nicholson ML. Naked small interfering RNA of caspase-3 in preservation solution and autologous blood perfusate protects isolated ischemic porcine kidneys. Transplantation 2011;91:501-7

 

Invited research highlight and review papers

  1. Zhang Y, Chen W and Yang B*: Renoprotection of Erythropoietin in Acute Kidney Injury, Current Protein & Peptide Science, in press.
  2. Yang C and Yang B*: Acute kidney injury in China: A neglected truth and perspective, Asian Journal of Urology 2016;3,4-5
  3. Yang C, Zhang C, Zhao Z, Zhu T, Yang B*. Fighting against kidney diseases with small interfering RNA: opportunities and challenges. J Transl Med 2015;13:39

 

Book Chapter

Yang C and Yang B: siRNA-induced RNAi Therapy in Acute Kidney Injury, in RNA Interference (ISBN: 978-953-51-4614-8), InTech

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Contact Details

Department of Infection, Immunity and Inflammation,
Maurice Shock Medical Sciences Building,
University Road,
Leicester, LE1 9HN, UK 

General enquiries to:
Alison Brown

T:+44 (0)116 252 2951
F:+44 (0)116 252 5030

Postgraduate enquiries to: 
Susan Kapadia (PhD)

Anna Boyce (MSc)

Erasmus and Study Abroad Co-ordinator:

Professor Peter Andrew

T: +44 (0)116 252 2951

Other contact details can be found in People

Head of Department: Professor Andy Wardlaw

Deputy Head of Department: Dr Shaun Heaphy

Respiratory Team Lead: Professor David Cousins

Microbial Sciences Team Lead: TBC

Renal team Lead: Dr Jon Barratt