Honorary Professor Alice Smith

Honorary Professor (Lifestyle Medicine)

  • Honorary Professor, Department of Infection, Immunity and Inflammation, University of Leicester
  • Senior NHS Researcher and Team Leader, Leicester Kidney Exercise Team, John Walls Renal Unit, University Hospitals of Leicester NHS Trust
  • Key Researcher, Leicester Biomedical Research Centre (Lifestyle)
  • Principal Investigator, Leicester Precision Medicine Institute
  • Faculty Member, National Centre for Sport and Exercise Medicine (East Midlands)
  • Faculty Member, EM-CLAHRC

Contact details

Kidney Lifestyle Team, Academic Unit, Leicester General Hospital, Leicester, LE5 4PW

Telephone +44 (0)116 258 4346

Email : alice.smith@le.ac.uk

Research Interests:

Professor Smith’s primary research interest is the role of physical activity, exercise and lifestyle management in kidney disease. Her specific background is in inflammation and immune function but her translational research programme encompasses lab-based exploratory and mechanistic work, outcome measure evaluation, observational and epidemiological studies, clinical efficacy trials, lifestyle intervention development and effectiveness testing, implementation and service evaluation. A strong track record of patient involvement and engagement, and qualitative exploration of patient perspectives and experience underpins all the work.

Areas of expertise:

Design and management of observational and interventional clinical trials of exercise, physical activity, lifestyle and patient experience in chronic disease.

Inflammation and immune function, including novel laboratory investigations.

Development of complex lifestyle interventions, including the application of qualitative research methods

Public and patient involvement and engagement in research.

Current Projects:

Professor Alice Smith leads the Leicester Kidney Lifestyle Team, a large multidisciplinary research group which aims to help kidney patients achieve the best possible health and wellbeing through appropriate lifestyle management. The team strive to produce high quality research and to involve patients, carers, healthcare professionals and stakeholders as partners to ensure delivery of research that meets the needs and expectations of our ultimate user-groups. Professor Smith’s research portfolio includes ~20 single- and multi-centre clinical trials, many of which are adopted on the NIHR portfolio, and have recruited some 6,000 participants since 2010.

Key recent publications:

G Kosmadakis, S John, EL Clapp, JL Viana, AC Smith, NC Bishop, A Bevington, P Owen, C McIntyre and J Feehally. Benefits of regular walking exercise for patients with severe pre-dialysis chronic kidney disease. Nephrol Dial Transplant 2012:27(3);997-1004.

Smith and JO Burton. Exercise in Kidney Disease and Diabetes : Time For Action. Journal of Renal Care 2012:38(Suppl 1);52-58.

HML Young, M Dungey, JO Burton, AC Smith. Haemodialysis-associated cramping: role and implications of exercise. British Journal of Renal Medicine 2012:17(2),12-14.

M Dungey, KL Hull, AC Smith, JO Burton, NC Bishop. Inflammatory Factors and Exercise in Chronic Kidney Disease. Int J Endocrinol. 2013;2013:569831. doi: 10.1155/2013/569831. Epub May 13

EL Watson, GC Kosmadakis, AC Smith, JL Viana, JR Brown, K Molyneux, IZA Pawluczyk, NC Bishop, S Shirreffs, RJ Maughan, PJ Owen, SG John, CW McIntyre, J Feehally, A Bevington. Combined walking exercise and alkali therapy in patients with CKD4-5 generates anabolic signals but no net suppression of muscle protein catabolism. Eur J Appl Physiol. 2013:113(8);2111-24.

DW Gould, MPM Graham-Brown, EL Watson, JL Viana and AC Smith. Physiological benefits of exercise in pre-dialysis chronic kidney disease. Nephrology 2014, DOI: 10.1111/nep.12285

JL Viana, NC Bishop, G Kosmadakis, EL Watson, A Bevington, J Feehally and AC Smith. Exercise in Chronic Kidney Disease: Impact on Immunity and Inflammation. J Am Soc Nephrol 2014, 25(9):2121-30. Selected for Global Press Release.

AC Smith and JO Burton. What I Tell My Patients About Exercise. Br J Renal Med 2014:19(1),15-18.

HJ Mackinnon, J Feehally and AC Smith. A review of the role of exercise and the factors affecting its uptake for people with Chronic Kidney Disease not requiring renal replacement therapy. PRILOZI 2015:36(1);37-46

J Neale and AC Smith. Cardiovascular risk factors following renal transplant. World J Transplant 2015:5(4); 183-95.

EL Watson, NJ Greening, JL Viana, J Aulakh, DH Bodicoat, J Barratt, J Feehally and AC Smith. Progressive Resistance Exercise Training in Chronic Kidney Disease: A Feasibility Study. Am J Kidney Dis 2015, 66(2):249-57.

Clarke AL, Young HML, Hull KL, Hudson N, Burton JO, Smith AC. Motivations and Barriers to Exercise in Chronic Kidney Disease : A Qualitative Study. Nephrol Dial Transplant 2015 30(11):1885-92

HML Young, Hudson N, Clarke AL, Dungey MR, Feehally J, Burton JO, Smith AC. Patient and staff perceptions of intradialytic exercise before and after implementation: A qualitative study. PLoS One. 2015 Jun 12;10(6):e0128995. doi: 10.1371/journal.pone.0128995. eCollection 2015.

M Dungey, NC Bishop, HML Young, JO Burton, AC Smith. The Impact of Exercising during Haemodialysis on Blood Pressure, Markers of Cardiac Injury and Systemic Inflammation – a randomised crossover study. Kidney and Blood Pressure Research 2015, 40(6), 593-604.

AL Clarke, T Yates, AC Smith, J Chilcot. Patient perceptions of chronic kidney disease and their association with psychosocial and clinical outcomes: a narrative review. Clin Kidney J 2016 9(3):494-502

Wilkinson TJ, Shur NF, Smith AC. Exercise as medicine in chronic kidney disease. Scand J Med Sci Sports. 2016 26(8):985-8

Neale J, Smith AC, Bishop NC. The Effects of Exercise and Sport in Solid Organ Transplant Recipients: A Review. Am J Phys Med Rehabil. 2017 Apr;96(4):273-288. doi: 10.1097/PHM.0000000000000599

Gould DW & Smith AC. UPDATE: Chapter 5 – Chronic Kidney Disease (CKD): Motivate to Move Education Package. http://gpcpd.walesdeanery.org/index.php/chapter-5-ckd2 October 2016

Graham-Brown MP, March DS, Churchward DR, Young HM, Dungey M, Lloyd S, Brunskill NJ, Smith AC, McCann GP, Burton JO. Design and methods of CYCLE-HD: improving cardiovascular health in patients with end stage renal disease using a structured programme of exercise: a randomised control trial. BMC Nephrol. 2016 17(1):69-81.

Dungey M, Young HML, Churchward DC, Burton JO, Smith AC, Bishop NC. Regular exercise during haemodialysis promotes an anti-inflammatory leukocyte profile. Clin Kidney J 2017;doi: 10.1093/ckj/sfx015.

Highton PJ, Neale J, Wilkinson TJ, Bishop NC, Smith AC. Physical Activity, Immune Function and Inflammation in Kidney Patients (the PINK Study) : A Feasibility Study Protocol. BMJ Open 2017;7: e014713. doi:10.1136/bmjopen-2016-014713

Wilkinson TJ, Gould DW, Watson EL, Smith AC. Commentary: Renal function estimation and Cockcroft–Gault formulas for predicting cardiovascular mortality in population based, cardiovascular risk, heart failure and post-myocardial infarction cohorts: The Heart ‘OMics’ in AGEing (HOMAGE) and the high-risk myocardial infarction database initiatives. Frontiers in Medicine 2017;4:77

Brown SA, Tyrer F, Clarke AL, Lloyd-Davies LH, Hull KL, Burton JO, Stein AG, Tarrant C, Smith AC. Patient Perceived Symptoms in Pre-End Stage Chronic Kidney Disease. Clin Kidney J 2017, doi: 10.1093/ckj/sfx057

Watson EL, Viana JL, Wimbury D, Martin N, Greening N, Barratt J, Smith AC. Intramuscular Molecular Responses to Resistance Exercise in Advanced Chronic Kidney Disease. Frontiers in Physiology 2017;8 doi: 10.3389/fphys.2017.00541

Bishop NC, Billany R, Smith AC. Participant Acceptability of Exercise in Kidney Disease: A Feasibility Study Protocol in Renal Transplant Recipients. BMJ Open 2017;7:e017494. doi:10.1136/bmjopen-2017-017494

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